scholarly journals Erratum: Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via α9β1 integrin

Oncogene ◽  
2015 ◽  
Vol 34 (42) ◽  
pp. 5408-5410 ◽  
Author(s):  
S Kale ◽  
R Raja ◽  
D Thorat ◽  
G Soundararajan ◽  
T V Patil ◽  
...  
Keyword(s):  
Cyclooxygenase 2 ◽  
Tumor Associated Macrophages ◽  
Melanoma Growth

scholarly journals Tumor-Associated Macrophages Promote Angiogenesis and Melanoma Growth via Adrenomedullin in a Paracrine and Autocrine Manner

2011 ◽  
Vol 17 (23) ◽  
pp. 7230-7239 ◽  
Author(s):  
Peiwen Chen ◽  
Yujie Huang ◽  
Rosabel Bong ◽  
Yanping Ding ◽  
Nan Song ◽  
...  
Keyword(s):  
Tumor Associated Macrophages ◽  
Melanoma Growth

scholarly journals MFG-E8 Drives Melanoma Growth by Stimulating Mesenchymal Stromal Cell–Induced Angiogenesis and M2 Polarization of Tumor-Associated Macrophages

2016 ◽  
Vol 76 (14) ◽  
pp. 4283-4292 ◽  
Author(s):  
Kazuya Yamada ◽  
Akihiko Uchiyama ◽  
Akihito Uehara ◽  
Buddhini Perera ◽  
Sachiko Ogino ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Tumor Associated Macrophages ◽  
M2 Polarization ◽  
Melanoma Growth

scholarly journals NFAT1 enhances the effects of tumor-associated macrophages on promoting malignant melanoma growth and metastasis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Hao Liu ◽  
Liping Yang ◽  
Min Qi ◽  
Jianglin Zhang
Keyword(s):  
Malignant Melanoma ◽  
Tumor Growth ◽  
Critical Role ◽  
Macrophage Infiltration ◽  
Migration And Invasion ◽  
Tumor Associated Macrophages ◽  
Human Malignant Melanoma ◽  
Tumor Growth And Metastasis ◽  
Melanoma Growth

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. Nuclear factor of activated T cell (NFAT1) has been shown to promote melanoma growth and metastasis in vivo. We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Melanoma-conditioned TAMs were obtained from human monocytes after incubation with conditioned medium from A375 cell culture. The phenotype of the macrophages was detected. Cell proliferation, migration, and invasion were evaluated. Human malignant melanoma tissues exhibited increased CD68+-macrophage infiltration and NFAT1 expression compared with the normal pigmented nevus tissues. Melanoma-conditioned TAMs displayed M2-like phenotype. Melanoma-conditioned TAMs also promoted proliferation, migration, and invasion of human malignant melanoma cell lines A375 and WM451. Furthermore, NFAT1 expression in TAMs was significantly increased compared with the M0 group. NFAT1 overexpression significantly strengthened the melanoma-conditioned TAM-mediated promotion of cell migration and invasion in A375 and WM451 cells, whereas NFAT1 knockdown exerted the opposite effects. Moreover, NFAT1 overexpression in melanoma-conditioned TAMs promoted CD68+-macrophage infiltration, tumor growth, and metastasis in vivo. NFAT1 may play a critical role in enhancing the TAM-mediated promotion of growth and metastasis in malignant melanoma.

scholarly journals Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation

Oncotarget ◽  
2016 ◽  
Vol 7 (51) ◽  
pp. 83976-83986 ◽  
Author(s):  
Xiaoming Rong ◽  
Bo Huang ◽  
Shuwei Qiu ◽  
Xiangpen Li ◽  
Lei He ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Vasculogenic Mimicry ◽  
Cyclooxygenase 2 ◽  
Tumor Associated Macrophages

Contribution of stromal and epithelial cells to cyclooxygenase-2 (COX-2) activity in Barrett's esophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A78-A79
Author(s):  
N BUTTAR ◽  
K WANG ◽  
M ANDERSON ◽  
L LUTZKE ◽  
K KRISHNADATH
Keyword(s):  
Epithelial Cells ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2
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