scholarly journals RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4

Oncogene ◽  
2015 ◽  
Vol 35 (13) ◽  
pp. 1703-1715 ◽  
Author(s):  
D K Poria ◽  
A Guha ◽  
I Nandi ◽  
P S Ray
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Programmed Cell Death ◽  
Tumor Suppressor Gene ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Suppressor Gene ◽  
Translation Repression ◽  
Programmed Cell Death 4

RNA-binding protein RBM6 as a tumor suppressor gene represses the growth and progression in laryngocarcinoma

Gene ◽  
2019 ◽  
Vol 697 ◽  
pp. 26-34 ◽  
Author(s):  
Qiwei Wang ◽  
Fang Wang ◽  
Waisheng Zhong ◽  
Hang Ling ◽  
Jixuan Wang ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Suppressor Gene

Abstract P4-05-09: Matrin 3: A novel micro-tubule associated RNA binding protein that acts as a potent tumor suppressor

2015 ◽  
Author(s):  
Panneerdoss Subbarayalu ◽  
Subapriya Rajamanickam ◽  
Suryavathi Viswanadhapalli ◽  
Nicholas Dybdal-Hargreaves ◽  
Santosh Timilsina ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Matrin 3 ◽  
Potent Tumor

scholarly journals Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 ◽  
Vol 16 (4) ◽  
pp. 1337-1345 ◽  
Author(s):  
RS Morrison ◽  
HJ Wenzel ◽  
Y Kinoshita ◽  
CA Robbins ◽  
LA Donehower ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

scholarly journals MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4)

2019 ◽  
Vol 39 (18) ◽  
Author(s):  
Pamela Ajuyah ◽  
Meredith Hill ◽  
Alireza Ahadi ◽  
Jing Lu ◽  
Gyorgy Hutvagner ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Programmed Cell Death ◽  
Tumor Suppressor Genes ◽  
Untranslated Region ◽  
Inhibitory Concentration ◽  
Mutational Analysis ◽  
Mirna Regulation ◽  
Programmed Cell Death 4 ◽  
The Relationship

ABSTRACT The regulation of tumor suppressor genes by microRNAs (miRNAs) is often demonstrated as a one-miRNA-to-one-target relationship. However, given the large number of miRNA sites within a 3′ untranslated region (UTR), most targets likely undergo miRNA cooperation or combinatorial action. Programmed cell death 4 (PDCD4), an important tumor suppressor, prevents neoplastic events and is commonly downregulated in cancer. This study investigates the relationship between miRNA 21 (miR-21) and miR-499 in regulating PDCD4. This was explored using miRNA overexpression, mutational analysis of the PDCD4 3′ UTR to assess regulation at each miRNA site, and 50% inhibitory concentration (IC50) calculations for combinatorial behavior. We demonstrate that the first miR-499 binding site within PDCD4 is inactive, but the two remaining sites are both required for PDCD4 suppression. Additionally, the binding of miR-21 to PDCD4 influenced miR-499 activity through an increase in its silencing potency and stabilization of its mature form. Furthermore, adjoining miRNA sites more than 35 nucleotides (nt) apart could potentially regulate thousands of 3′ UTRs, similar to that observed between miR-21 and miR-499. The regulation of PDCD4 serves as a unique example of regulatory action by multiple miRNAs. This relationship was predicted to occur on thousands of targets and may represent a wider mode of miRNA regulation.

scholarly journals The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145792 ◽  
Author(s):  
Wendy M. McKimpson ◽  
Ziqiang Yuan ◽  
Min Zheng ◽  
Judy S. Crabtree ◽  
Steven K. Libutti ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Development ◽  
Suppressor Gene ◽  
Tissue Specific ◽  
Specific Manner

scholarly journals Granzyme B-induced Cell Death Involves Induction of p53 Tumor Suppressor Gene and Its Activation in Tumor Target Cells

2007 ◽  
Vol 282 (45) ◽  
pp. 32991-32999 ◽  
Author(s):  
Franck Meslin ◽  
Jerome Thiery ◽  
Catherine Richon ◽  
Abdelali Jalil ◽  
Salem Chouaib
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Granzyme B ◽  
Suppressor Gene ◽  
Target Cells ◽  
Tumor Target ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene
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