Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape

Oncogene ◽  
2015 ◽  
Vol 35 (12) ◽  
pp. 1596-1601 ◽  
Author(s):  
C Wiel ◽  
B Gras ◽  
D Vindrieux ◽  
M Warnier ◽  
D Gitenay ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Formation ◽  
Multidrug Resistance Protein ◽  
Multidrug Resistance Protein 3 ◽  
Resistance Protein

scholarly journals Involvement of the Multidrug Resistance Protein 3 in Drug Sensitivity and Its Expression in Human Glioma

2001 ◽  
Vol 92 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Sei Haga ◽  
Eiji Hinoshita ◽  
Kiyonobu Ikezaki ◽  
Masashi Fukui ◽  
George L. Scheffer ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Drug Sensitivity ◽  
Multidrug Resistance Protein ◽  
Human Glioma ◽  
Multidrug Resistance Protein 3 ◽  
Resistance Protein

Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver

2003 ◽  
Vol 304 (2) ◽  
pp. 524-530 ◽  
Author(s):  
Monika Hitzl ◽  
Kathrin Klein ◽  
Ulrich M. Zanger ◽  
Peter Fritz ◽  
Andreas K. Nüssler ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Human Liver ◽  
Multidrug Resistance Protein ◽  
Multidrug Resistance Protein 3 ◽  
Resistance Protein

Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3

2003 ◽  
Vol 284 (2) ◽  
pp. G280-G289 ◽  
Author(s):  
Curtis J. Oleschuk ◽  
Roger G. Deeley ◽  
Susan P. C. Cole
Keyword(s):  
Multidrug Resistance ◽  
Substrate Specificity ◽  
Multidrug Resistance Protein ◽  
Wild Type ◽  
Multidrug Resistance Protein 3 ◽  
17Β Estradiol ◽  
Resistance Protein ◽  
Estradiol 17Β ◽  
Taurocholate Transport

Multidrug resistance protein 3 (MRP3) is an ATP-dependent transporter of 17β-estradiol 17β(d-glucuronide) (E217βG), leukotriene C4 (LTC4), methotrexate, and the bile salts taurocholate and glycocholate. In the present study, the role of a highly conserved Trp residue at position 1242 on MRP3 transport function was examined by expressing wild-type MRP3 and Ala-, Cys-, Phe-, Tyr-, and Pro-substituted mutants in human embryonic kidney 293T cells. Four MRP3-Trp1242 mutants showed significantly increased E217βG uptake, whereas transport by the Pro mutant was undetectable. Similarly, the Pro mutant did not transport LTC4. By comparison, LTC4transport by the Ala, Cys, Phe, and Tyr mutants was reduced by ∼35%. The Ala, Cys, Phe, and Tyr mutants all showed greatly reduced methotrexate and leucovorin transport, except the Tyr mutant, which transported leucovorin at levels comparable with wild-type MRP3. In contrast, the MRP3-Trp1242 substitutions did not significantly affect taurocholate transport or taurocholate and glycocholate inhibition of E217βG uptake. Thus Trp1242 substitutions markedly alter the substrate specificity of MRP3 but leave bile salt binding and transport intact.

scholarly journals Multidrug resistance protein 3 R652G may reduce susceptibilityto idiopathic infant cholestasis

2009 ◽  
Vol 15 (46) ◽  
pp. 5855 ◽  
Author(s):  
Xiu-Qi Chen ◽  
Lin-Lin Wang ◽  
Qing-Wen Shan ◽  
Qing Tang ◽  
Shu-Jun Lian
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Protein ◽  
Multidrug Resistance Protein 3 ◽  
Resistance Protein

scholarly journals Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis

2016 ◽  
Vol 90 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Zainab M. Mahdi ◽  
Uta Synal-Hermanns ◽  
Aylin Yoker ◽  
Kaspar P. Locher ◽  
Bruno Stieger
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Protein ◽  
Multidrug Resistance Protein 3 ◽  
Resistance Protein
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