scholarly journals SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer

Oncogene ◽  
2014 ◽  
Vol 34 (33) ◽  
pp. 4391-4402 ◽  
Author(s):  
F Han ◽  
W Liu ◽  
X Jiang ◽  
X Shi ◽  
L Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis

scholarly journals The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (26) ◽  
pp. 22666-22679 ◽  
Author(s):  
Christophe Deben ◽  
An Wouters ◽  
Ken Op de Beeck ◽  
Jolien van Den Bossche ◽  
Julie Jacobs ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cell Apoptosis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Cell Apoptosis ◽  
Mdm2 Inhibitor

scholarly journals NFAT c1 is a tumor suppressor in hepatocellular carcinoma and induces tumor cell apoptosis by activating the FasL‐mediated extrinsic signaling pathway

2018 ◽  
Vol 7 (9) ◽  
pp. 4701-4717 ◽  
Author(s):  
Sanrong Xu ◽  
Penghao Shu ◽  
Song Zou ◽  
Xiaofeng Shen ◽  
Yuanqian Qu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Cell ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis

FOXD3, frequently methylated in colorectal cancer, acts as a tumor suppressor and induces tumor cell apoptosis under ER stress via p53

2019 ◽  
Vol 41 (9) ◽  
pp. 1253-1262 ◽  
Author(s):  
Ming Xu ◽  
Jing Zhu ◽  
Shuiping Liu ◽  
Chan Wang ◽  
Qinglan Shi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Suppressor ◽  
Tumor Cell ◽  
Er Stress ◽  
Cell Lines ◽  
Cell Apoptosis ◽  
Primary Tumors ◽  
Tumor Cell Apoptosis ◽  
Specific Pcr ◽  
Forkhead Box

Abstract Forkhead box D3 (FOXD3), an important member of the forkhead box transcription factor family, has many biological functions. However, the role and signaling pathways of FOXD3 in colorectal cancer (CRC) are still unclear. We examined FOXD3 expression and methylation in normal colon mucosa, CRC cell lines and primary tumors by reverse transcription–polymerase chain reaction, methylation-specific PCR and bisulfite genomic sequencing. We also evaluated its tumor-suppressive function by examining its modulation of apoptosis under endoplasmic reticulum (ER) stress in CRC cells. The FOXD3 target signal pathway was identified by western blotting, immunofluorescence and chromatin immunoprecipitation. We found that FOXD3 was frequently methylated and silenced in CRC cell lines and was downregulated in CRC tissues compared with paired adjacent non-tumor tissues. Meanwhile, low FOXD3 protein expression was significantly correlated with poor histopathological grading, lymph node metastasis and poor prognosis of patients, indicating its potential as a tumor marker that may be of potential value as a therapeutic target for CRC. Moreover, restoration of FOXD3 expression inhibited the proliferation and migration of tumor cells. FOXD3 also increased mitochondrial apoptosis through the unfolded protein response under ER stress. Furthermore, we found that FOXD3 could bind directly to the promoter of p53 and enhance its expression. Knockdown of p53 impaired the effect of apoptosis induced by FOXD3. In conclusion, we showed for the first time that FOXD3, which is frequently methylated in CRC, acted as a tumor suppressor inducing tumor cell apoptosis under ER stress via p53.

Mechanism of TRAIL Induced Tumor Cell Apoptosis and Application of TRAIL Based on Tumor Therapy

2012 ◽  
Vol 28 (6) ◽  
pp. 448 ◽  
Author(s):  
Ling ZHU ◽  
Xiangxi WANG ◽  
Xuemei LI ◽  
Jinliang YANG
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Therapy ◽  
Tumor Cell Apoptosis

scholarly journals Hsp60 Regulation of Tumor Cell Apoptosis

2007 ◽  
Vol 283 (8) ◽  
pp. 5188-5194 ◽  
Author(s):  
Jagadish C. Ghosh ◽  
Takehiko Dohi ◽  
Byoung Heon Kang ◽  
Dario C. Altieri
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis
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