scholarly journals Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization

Oncogene ◽  
2013 ◽  
Vol 33 (22) ◽  
pp. 2866-2875 ◽  
Author(s):  
T Rivera Vargas ◽  
S Boudoukha ◽  
A Simon ◽  
M Souidi ◽  
S Cuvellier ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Cancer Cells ◽  
Nuclear Localization ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Post Transcriptional Regulation

scholarly journals Transcriptional Regulation of hTREX84 in Human Cancer Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43610 ◽  
Author(s):  
Shanchun Guo ◽  
Mingli Liu ◽  
Andrew K. Godwin
Keyword(s):  
Transcriptional Regulation ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

Nuclear localization of Formyl-Peptide Receptor 2 in human cancer cells

2016 ◽  
Vol 603 ◽  
pp. 10-19 ◽  
Author(s):  
Fabio Cattaneo ◽  
Melania Parisi ◽  
Tiziana Fioretti ◽  
Daniela Sarnataro ◽  
Gabriella Esposito ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Nuclear Localization ◽  
Human Cancer ◽  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Human Cancer Cells ◽  
Formyl Peptide

scholarly journals ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells

2007 ◽  
Vol 28 (8) ◽  
pp. 1752-1758 ◽  
Author(s):  
Hirotoshi Kikuchi ◽  
Chiharu Uchida ◽  
Takayuki Hattori ◽  
Tomoyasu Isobe ◽  
Yoshihiro Hiramatsu ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Cyclin D1 ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

Nuclear localization of alkaline phosphatase in cultured human cancer cells

2003 ◽  
Vol 36 (1) ◽  
pp. 47-51 ◽  
Author(s):  
K. Yamamoto ◽  
Takumi Awogi ◽  
Keiji Okuyama ◽  
Nobuo Takahashi
Keyword(s):  
Alkaline Phosphatase ◽  
Cancer Cells ◽  
Nuclear Localization ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Cultured Human Cancer Cells

scholarly journals Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase

2020 ◽  
Vol 13 (10) ◽  
pp. 286
Author(s):  
Anna A. Plyasova ◽  
Marina V. Pokrovskaya ◽  
Olga M. Lisitsyna ◽  
Vadim S. Pokrovsky ◽  
Svetlana S. Alexandrova ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Nuclear Localization ◽  
Rhodospirillum Rubrum ◽  
Human Cancer ◽  
Fluorescent Microscopy ◽  
Fluorescein Isothiocyanate ◽  
Telomerase Activity ◽  
Human Cancer Cells ◽  
Chromatin Relaxation ◽  
Dual Mechanism

The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment. Rhodospirillum rubrum (RrA) has dual mechanism of action and plays a role in the suppression of telomerase activity. The aim of this work was to investigate the possible mechanism of RrA penetration into human cancer cells. Labeling of widely used L-ASNases by fluorescein isothiocyanate followed by flow cytometry and fluorescent microscopy demonstrated that only RrA can interact with cell membranes. The screening of inhibitors of receptor-mediated endocytosis demonstrated the involvement of clathrin receptors in RrA penetration into cells. Confocal microscopy confirmed the cytoplasmic and nuclear localization of RrA in human breast cancer SKBR3 cells. Two predicted nuclear localization motifs allow RrA to penetrate into the cell nucleus and inhibit telomerase. Chromatin relaxation promoted by different agents can increase the ability of RrA to suppress the expression of telomerase main catalytic subunit. Our study demonstrated for the first time the ability of RrA to penetrate into human cancer cells and the involvement of clathrin receptors in this process.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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