scholarly journals Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome

Oncogene ◽  
2011 ◽  
Vol 30 (33) ◽  
pp. 3585-3598 ◽  
Author(s):  
J Pal ◽  
R Bertheau ◽  
L Buon ◽  
A Qazi ◽  
R B Batchu ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Genomic Evolution ◽  
Alu Sequences ◽  
Adenocarcinoma Cells ◽  
Barrett’S Adenocarcinoma

T1154 Role of Homologous Recombination in Telomere Maintenance and Evidence of ALT Pathway in Barrett's Adenocarcinoma Cells

2010 ◽  
Vol 138 (5) ◽  
pp. S-500
Author(s):  
Robert C. Bertheau ◽  
Jagannath Pal ◽  
Jason Y. Wong ◽  
Mariateresa Fulciniti ◽  
Ramesh B. Batchu ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Telomere Maintenance ◽  
Adenocarcinoma Cells ◽  
Barrett’S Adenocarcinoma

scholarly journals Impact of homologous and non-homologous recombination in the genomic evolution of Escherichia coli

BMC Genomics ◽  
2012 ◽  
Vol 13 (1) ◽  
pp. 256 ◽  
Author(s):  
Xavier Didelot ◽  
Guillaume Méric ◽  
Daniel Falush ◽  
Aaron E Darling
Keyword(s):  
Escherichia Coli ◽  
Homologous Recombination ◽  
Genomic Evolution

scholarly journals The global dissemination of hospital clones of Enterococcus faecium

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sebastiaan J. van Hal ◽  
◽  
Rob J. L. Willems ◽  
Theodore Gouliouris ◽  
Susan A. Ballard ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Enterococcus Faecium ◽  
Core Genome ◽  
Local Level ◽  
Drug Resistant ◽  
Genomic Evolution ◽  
The Core ◽  
Antimicrobial Resistance Genes ◽  
Conserved Genes ◽  
Hospital Associated Infections

Abstract Background The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood. Methods A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of Enterococcus faecium was assembled (n = 973). We analysed, using a novel analysis approach, global diversity in terms of both the dynamics of the accessory genome and homologous recombination among conserved genes. Results Two main modes of genomic evolution continue to shape E. faecium: the acquisition and loss of genes, including antimicrobial resistance genes, through mobile genetic elements including plasmids, and homologous recombination of the core genome. These events lead to new clones emerging at the local level, followed by the erosion of signals of clonality through recombination, and in some identifiable cases producing new clonal clusters. These patterns lead to new, emerging lineages which are able to spread globally over relatively short timeframes. Conclusions The ability of A1 E. faecium to continually present new combinations of genes for potential selection suggests that controlling this pathogen will remain challenging but establishing a framework for understanding genomic evolution is likely to aid in tracking the threats posed by newly emerging lineages.

scholarly journals Telomere Maintenance in Laser Capture Microdissection–Purified Barrett's Adenocarcinoma Cells and Effect of Telomerase Inhibition In vivo

2008 ◽  
Vol 14 (15) ◽  
pp. 4971-4980 ◽  
Author(s):  
Masood A. Shammas ◽  
Aamer Qazi ◽  
Ramesh B. Batchu ◽  
Robert C. Bertheau ◽  
Jason Y.Y. Wong ◽  
...  
Keyword(s):  
Laser Capture Microdissection ◽  
Telomere Maintenance ◽  
Telomerase Inhibition ◽  
Adenocarcinoma Cells ◽  
Barrett’S Adenocarcinoma ◽  
Laser Capture

T1176 Role of Recombinase (RAD51) in Ongoing Genomic Instability and Proliferation in Barrett's Adenocarcinoma Cells

2010 ◽  
Vol 138 (5) ◽  
pp. S-505
Author(s):  
Jagannath Pal ◽  
Robert C. Bertheau ◽  
Leutz Buon ◽  
Aamer Qazi ◽  
Ramesh B. Batchu ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Adenocarcinoma Cells ◽  
Barrett’S Adenocarcinoma
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