scholarly journals Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor

Oncogene ◽  
2012 ◽  
Vol 31 (42) ◽  
pp. 4536-4549 ◽  
Author(s):  
S Germann ◽  
L Gratadou ◽  
E Zonta ◽  
E Dardenne ◽  
B Gaudineau ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dual Role ◽  
Rna Helicases

scholarly journals Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells

2019 ◽  
Vol 12 (1) ◽  
pp. 32-41
Author(s):  
Cristina de Miguel ◽  
Josefa Cruz ◽  
David Martín ◽  
Xavier Franch-Marro
Keyword(s):  
Transcription Factor ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Progenitor Cells ◽  
Posterior Part ◽  
Dual Role ◽  
Fibroblast Growth ◽  
Fgf Signaling

Abstract Adult progenitor cells activation is a key event in the formation of adult organs. In Drosophila, formation of abdominal adult trachea depends on the specific activation of tracheal adult progenitors (tracheoblasts) at the Tr4 and Tr5 spiracular branches. Proliferation of these tracheoblasts generates a pool of tracheal cells that migrate toward the posterior part of the trachea by the activation of the branchless/fibroblast growth factor (Bnl/FGF) signaling to form the abdominal adult trachea. Here, we show that, in addition to migration, Bnl/FGF signaling, mediated by the transcription factor Pointed, is also required for tracheoblast proliferation. This tracheoblast activation relies on the expression of the FGF ligand bnl in their nearby branches. Finally, we show that, in the absence of the transcription factor Cut (Ct), Bnl/FGF signaling induces endoreplication of tracheoblasts partially by promoting fizzy-related expression. Altogether, our results suggest a dual role of Bnl/FGF signaling in tracheoblasts, inducing both proliferation and endoreplication, depending on the presence or absence of the transcription factor Ct, respectively.

scholarly journals Dual Role of Sp3 Transcription Factor as an Inducer of Apoptosis and a Marker of Tumour Aggressiveness

PLoS ONE ◽  
2009 ◽  
Vol 4 (2) ◽  
pp. e4478 ◽  
Author(s):  
Khadija Essafi-Benkhadir ◽  
Sébastien Grosso ◽  
Alexandre Puissant ◽  
Guillaume Robert ◽  
Makram Essafi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dual Role

scholarly journals Dual Role of the Trps1 Transcription Factor in Dentin Mineralization

2014 ◽  
Vol 289 (40) ◽  
pp. 27481-27493 ◽  
Author(s):  
Maria Kuzynski ◽  
Morgan Goss ◽  
Massimo Bottini ◽  
Manisha C. Yadav ◽  
Callie Mobley ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dual Role ◽  
Dentin Mineralization

scholarly journals Dual role of Bnl/Fgf signaling in proliferation and endoreplication of Drosophila tracheal adult progenitor cells

2018 ◽  
Author(s):  
Cristina de Miguel ◽  
Josefa Cruz ◽  
David Martín ◽  
Xavier Franch-Marro
Keyword(s):  
Transcription Factor ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Dual Role ◽  
Fgf Signaling ◽  
Respiratory Organ ◽  
Specific Expression ◽  
Tracheal System ◽  
Differentiated Cells

AbstractAdult progenitor cells activation is a key event in the formation of adult organs during development. The initiation of proliferation of these progenitor cells requires specific temporal signals, mostly of them still unknown. In Drosophila, formation of adult tracheal system depends on the activation of tracheal adult progenitors (tracheoblasts) of Tr4 and Tr5 tracheal metamers specific spiracular branches (SB) during the last larval stage. The mitotic activity of these tracheoblasts generate a pool of tracheal differentiated cells that migrate during pupal development along the larval trachea by the activation of the Branchless (Bnl)/Fibroblast growth factor (FGF) signaling to form the abdominal adult tracheal system. In here, we found that, in addition to migration, Bnl/FGF signaling, mediated by the transcription factor Pointed, is also required for adult progenitor cell proliferation in the SBs. Moreover, we found that tracheoblast proliferation in Tr4 and Tr5 SBs relies on the specific expression of the FGF ligand Bnl in their nearby transverse connective branches. Finally, we also show that, in absence of the transcription factor Cut (Ct), Bnl/FGF signaling induces endoreplication of differentiated tracheoblast daughter cells by in part promoting Fizzy-related (Fzr) expression. Altogether, our results suggest a dual role of Bnl/FGF signaling in tracheal adult progenitors, inducing both proliferation and endoreplication of tracheoblasts in late larval development, depending on the presence or absence of the transcription factor ct, respectively.Author summaryThe generation of adult organs and tissue renewal are complex processes that depend on the proliferation and posterior differentiation of undifferentiated progenitor cells in a temporal coordinated manner. Although many signals that regulate the activity of progenitor cells have been identified, the characterization of the mechanisms underlying the temporal and spatial control of such events remain unknown. The tracheal system of Drosophila, the respiratory organ, forms during embryogenesis and it is remodeled during metamorphosis from quiescent adult progenitor cells that proliferate. We have discovered that this proliferation depends on the activation of the FGF signaling as mutations that either inactivate or over-activate the pathway blocks cell division or induced over-proliferation of progenitor cells, respectively. Interestingly, we have found that the same signaling pathway also controls tracheal progenitor cells differentiation by promoting endoreplication. We found that this dual role of FGF signaling in adult progenitor cells, depends on the presence or absence of the transcription factor Cut. Altogether, our results, reveal the mechanism that control the division and differentiation of progenitor cells and open the possibility that analogous signaling pathway may play a similar role in vertebrate stem cell regulation and tumor growth.

scholarly journals Unravelling the transcriptional regulation of Saccharomyces cerevisiae UGA genes: the dual role of transcription factor Leu3

Microbiology ◽  
2017 ◽  
Vol 163 (11) ◽  
pp. 1692-1701 ◽  
Author(s):  
Marcos Palavecino-Ruiz ◽  
Mariana Bermudez-Moretti ◽  
Susana Correa-Garcia
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Dual Role

scholarly journals Phytohormone sensing in the biotrophic fungus Ustilago maydis – the dual role of the transcription factor Rss1

2016 ◽  
Vol 102 (2) ◽  
pp. 290-305 ◽  
Author(s):  
Franziska Rabe ◽  
Denise Seitner ◽  
Lisa Bauer ◽  
Fernando Navarrete ◽  
Angelika Czedik‐Eysenberg ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Ustilago Maydis ◽  
Dual Role ◽  
Biotrophic Fungus

Dual role of the NF-κB transcription factor in the death of immature neurons

Neuroscience ◽  
2001 ◽  
Vol 108 (3) ◽  
pp. 517-526 ◽  
Author(s):  
V Castagné ◽  
K Lefèvre ◽  
P.G.H Clarke
Keyword(s):  
Transcription Factor ◽  
Dual Role ◽  
Immature Neurons

The role of transcription factor Egr‐1 in IL‐1 up‐regulation of tubular CD44 expression

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A92-A92
Author(s):  
Takazoe K ◽  
Foti R ◽  
Hurst La ◽  
Atkins Rc ◽  
Nikolic‐Paterson DJ.
Keyword(s):  
Transcription Factor ◽  
Cd44 Expression
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