scholarly journals microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ

Oncogene ◽  
2011 ◽  
Vol 31 (36) ◽  
pp. 4045-4053 ◽  
Author(s):  
J Datta ◽  
A Smith ◽  
J C Lang ◽  
M Islam ◽  
D Dutt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Neck Squamous Cell Carcinoma ◽  
Candidate Tumor Suppressor Gene

Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma

Tumor Biology ◽  
2015 ◽  
Vol 36 (10) ◽  
pp. 7865-7872 ◽  
Author(s):  
Keiji Kikuchi ◽  
Akira Noguchi ◽  
Rika Kasajima ◽  
Yohei Miyagi ◽  
Daisuke Hoshino ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Neck Squamous Cell Carcinoma

scholarly journals The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma

2018 ◽  
Vol 97 (6) ◽  
pp. 645-653 ◽  
Author(s):  
T. Fukusumi ◽  
J.A. Califano
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Family Members ◽  
Notch Pathway ◽  
Suppressor Gene ◽  
Neck Squamous Cell Carcinoma ◽  
Notch1 Mutations

Comprehensive genomic analyses have been performed for head and neck squamous cell carcinoma (HNSCC), revealing a significant rate of NOTCH1 mutations and identifying NOTCH1 as the second most frequently mutated gene after TP53. Most NOTCH1 mutations are considered inactivating, indicating that NOTCH1 is a tumor suppressor gene. On the other hand, cohorts from Asian populations with HNSCC have shown activating NOTCH1 mutations. HNSCC with NOTCH1 mutations have a worse prognosis than the NOTCH1 wild-type tumors. Additional data on other NOTCH family members have shown that NOTCH promotes HNSCC progression. NOTCH family members, including NOTCH pathway genes, are upregulated in HNSCC compared with normal tissues, and inhibition of the NOTCH pathway decreases cell proliferation and invasion. NOTCH activity in HNSCC is therefore contextual, and NOTCH in HNSCC is considered to have a bimodal role as a tumor suppressor and an oncogene. In this review, recent understandings of NOTCH pathway genes, including NOTCH genes, in HNSCC are described. In addition, the implications of NOTCH pathway alteration for HNSCC-specific NOTCH-targeted cancer therapy are explored.

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