scholarly journals Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

Oncogene ◽  
2011 ◽  
Vol 31 (27) ◽  
pp. 3213-3222 ◽  
Author(s):  
E J Gallagher ◽  
Y Fierz ◽  
A Vijayakumar ◽  
N Haddad ◽  
S Yakar ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Mouse Model ◽  
Tumor Growth ◽  
Mammary Tumor ◽  
Mammary Tumor Growth

scholarly journals Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model

Oncogene ◽  
2012 ◽  
Vol 32 (8) ◽  
pp. 961-967 ◽  
Author(s):  
N Alikhani ◽  
R D Ferguson ◽  
R Novosyadlyy ◽  
E J Gallagher ◽  
E J Scheinman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Pulmonary Metastasis ◽  
Mammary Tumor ◽  
Mammary Tumor Growth

ApoE-Deficient Mouse Model Exhibits Significantly Enhanced Mammary Tumor Growth and Pulmonary Metastases

2011 ◽  
pp. P1-597-P1-597
Author(s):  
Nyosha Alikhani ◽  
Rulan Novosyadlyy ◽  
Rosalyn Ferguson ◽  
Shoshana Yakar ◽  
Derek LeRoith
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Mammary Tumor ◽  
Pulmonary Metastases ◽  
Deficient Mouse ◽  
Mammary Tumor Growth ◽  
Apoe Deficient Mouse

scholarly journals Should diabetic women with breast cancer have their own intervention studies?

2011 ◽  
Vol 19 (1) ◽  
pp. C13-C17
Author(s):  
David A Potter ◽  
Douglas Yee ◽  
Zhijun Guo ◽  
Mariangellys Rodriguez
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Tumor Growth ◽  
Calorie Restriction ◽  
Mammary Tumor ◽  
Intervention Studies ◽  
Diabetic Mouse ◽  
Mouse Mammary Tumor ◽  
Mammary Tumor Growth ◽  
Postmenopausal Obesity

This commentary on ‘Calorie restriction and rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity’ by Nogueiraet al., published in this issue ofEndocrine-Related Cancer, addresses the challenges of translating diet, exercise, and pharmacologic trials in diabetic mouse mammary tumor models to human studies. We propose that trials specifically designed to test such interventions in diabetic women with breast cancer would be valuable and informative.

scholarly journals Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice

2015 ◽  
Vol 227 (3) ◽  
pp. 143-151 ◽  
Author(s):  
Sarit Ben-Shmuel ◽  
Eyal J Scheinman ◽  
Rola Rashed ◽  
Zila Shen Orr ◽  
Emily J Gallagher ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Mammary Tumor ◽  
Mammary Cancer ◽  
Female Mice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Mammary Tumor Growth

Obesity and type 2 diabetes (T2D) are associated with an increased risk of breast cancer incidence and mortality. Common features of obesity and T2D are insulin resistance and hyperinsulinemia. A mammary tumor promoting effect of insulin resistance and hyperinsulinemia was demonstrated in the transgenic female MKR mouse model of pre-diabetes inoculated with mammary cancer cells. Interestingly, in MKR mice, as well as in other diabetic mouse models, males exhibit severe hyperglycemia, while females display insulin resistance and hyperinsulinemia with only a mild increase in blood glucose levels. This gender-specific protection from hyperglycemia may be attributed to estradiol, a key player in the regulation of the metabolic state, including obesity, glucose homeostasis, insulin resistance, and lipid profile. The aim of this study was to investigate the effects of ovariectomy (including the removal of endogenous estradiol) on the metabolic state of MKR female mice and subsequently on the growth of Mvt-1 mammary cancer cells, inoculated into the mammary fat pad of ovariectomized mice, compared with sham-operated mice. The results showed an increase in body weight, accompanied by increased fat mass, elevated blood glucose levels, and hypercholesterolemia, in ovariectomized MKR mice. In addition, mammary tumor growth was significantly higher in these mice. The results suggest that ovarian hormone deficiency may promote impaired metabolic homeostasis in the hyperinsulinemic MKR female mice, which in turn is associated with an increased growth of mammary tumors.

Abstract A155: The Rac and PAK inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model.

2013 ◽  
Author(s):  
Linette Castillo-Pichardo ◽  
Tessa Humphries-Bickley ◽  
Eliud Hernandez ◽  
Columba de la Parra ◽  
Luis Cubano ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Nude Mouse ◽  
Mammary Tumor ◽  
Nude Mouse Model ◽  
Mammary Tumor Growth ◽  
Tumor Growth And Metastasis
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