scholarly journals A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion

Oncogene ◽  
2011 ◽  
Vol 31 (23) ◽  
pp. 2888-2898 ◽  
Author(s):  
V H Rao ◽  
A Kandel ◽  
D Lynch ◽  
Z Pena ◽  
N Marwaha ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Human Head ◽  
Migration And Invasion ◽  
Positive Feedback Loop

scholarly journals Transcriptional Regulation of GDF15 by EGR1 Promotes Head and Neck Cancer Progression through a Positive Feedback Loop

2021 ◽  
Vol 22 (20) ◽  
pp. 11151
Author(s):  
Yanli Jin ◽  
Seung-Nam Jung ◽  
Mi Ae Lim ◽  
Chan Oh ◽  
Yudan Piao ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Transforming Growth Factor ◽  
Xenograft Model ◽  
Migration And Invasion ◽  
Positive Feedback Loop ◽  
Mouse Xenograft Model

Growth and differentiation factor 15 (GDF15), a divergent member of the transforming growth factor-β (TGF-β) superfamily, has been reported to be overexpressed in different kinds of cancer types. However, the function and mechanism of GDF15 in head and neck cancer (HNC) remains unclear. The Cancer Genome Atlas (TCGA) data show that the expression of GDF15 is significantly associated with tumor AJCC stage, lymph vascular invasion and tumor grade in HNC. In this study, we confirmed that knockdown of GDF15 attenuated: cell proliferation, migration and invasion via regulation of EMT through a canonical pathway; SMAD2/3 and noncanonical pathways; PI3K/AKT and MEK/ERK in HNC cell lines. Furthermore, we found that early growth response 1 (EGR1) was a transcription factor of GDF15. Interestingly, we also demonstrated that GDF15 could regulate the expression of EGR1, which meant a positive feedback loop occurred between these two factors. Moreover, combined inhibition of both GDF15 and EGR1 in a HNC mouse xenograft model showed significantly decreased tumor volume compared to inhibition of EGR1 or GDF15 alone. Our study showed that the GDF15–EGR1 signaling axis may be a good target in HNC patients.

scholarly journals Photodynamic therapy suppresses the migration and invasion of head and neck cancer cells in vitro

Oral Oncology ◽  
2007 ◽  
Vol 43 (4) ◽  
pp. 358-365 ◽  
Author(s):  
Ting-Hua Yang ◽  
Chin-Tin Chen ◽  
Cheng-Ping Wang ◽  
Pei-Jen Lou
Keyword(s):  
Head And Neck Cancer ◽  
Photodynamic Therapy ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Migration And Invasion

Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress in Human Head and Neck Cancer Cells

2010 ◽  
Vol 49 ◽  
pp. S102-S103
Author(s):  
Andrean L. Simons ◽  
Kevin P. Orcutt ◽  
Arlene D. Parsons ◽  
Zita A. Sibenaller ◽  
Peter M. Scarbrough ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head ◽  
Egfr Signaling ◽  
Metabolic Oxidative Stress

scholarly journals Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e48175 ◽  
Author(s):  
Arya Sobhakumari ◽  
Laurie Love-Homan ◽  
Elise V. M. Fletcher ◽  
Sean M. Martin ◽  
Arlene D. Parsons ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head

The effect of cyclin D1 overexpression in human head and neck cancer cells

2004 ◽  
Vol 262 (5) ◽  
pp. 379-383 ◽  
Author(s):  
Torahiko Nakashima ◽  
Yuichiro Kuratomi ◽  
Ryuji Yasumatsu ◽  
Muneyuki Masuda ◽  
Koji Koike ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cyclin D1 ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head

scholarly journals Low-intensity ultrasound enhances the anticancer activity of cetuximab in human head and neck cancer cells

2012 ◽  
Vol 5 (1) ◽  
pp. 11-16 ◽  
Author(s):  
TAKASHI MASUI ◽  
ICHIRO OTA ◽  
MASATOSHI KANNO ◽  
KATSUNARI YANE ◽  
HIROSHI HOSOI
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head ◽  
Low Intensity ◽  
Low Intensity Ultrasound

533Combined effect of paclitaxel and radiation on human head and neck cancer cells (ZMK-1)

1996 ◽  
Vol 40 ◽  
pp. S136
Author(s):  
O. Pradier ◽  
M. Rave-Fränk ◽  
H. Schmidberger ◽  
D. Laurent ◽  
E. Weiss ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head
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