scholarly journals Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation

Oncogene ◽  
2011 ◽  
Vol 31 (3) ◽  
pp. 390-401 ◽  
Author(s):  
D P Mathiasen ◽  
C Egebjerg ◽  
S H Andersen ◽  
B Rafn ◽  
P Puustinen ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Dependent Signal ◽  
Amplification Cascade

scholarly journals Oligo(dA-dT)-dependent signal amplification for the detection of proteins in cells

BioTechniques ◽  
2004 ◽  
Vol 36 (5) ◽  
pp. 856-863 ◽  
Author(s):  
Ken-ichi Hanaki ◽  
Seii Ohka ◽  
Kenji Yamamoto ◽  
Akio Nomoto ◽  
Hiroshi Yoshikura
Keyword(s):  
Signal Amplification ◽  
Dependent Signal ◽  
In Cells

scholarly journals Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis

2015 ◽  
Vol 6 (8) ◽  
pp. 4978-4985 ◽  
Author(s):  
Sean Goggins ◽  
Barrie J. Marsh ◽  
Anneke T. Lubben ◽  
Christopher G. Frost
Keyword(s):  
Signal Transduction ◽  
Signal Amplification ◽  
Transfer Hydrogenation ◽  
Hydrogenation Catalyst ◽  
Enzyme Substrate ◽  
Amplification Cascade

An enzyme-triggered catalytic signal amplification cascade is described through the design of a novel enzyme substrate that selectively activates an organometallic transfer hydrogenation catalyst once triggered.

scholarly journals EzyAmp signal amplification cascade enables isothermal detection of nucleic acid and protein targets

2016 ◽  
Vol 75 ◽  
pp. 59-66 ◽  
Author(s):  
Evelyn M. Linardy ◽  
Simon M. Erskine ◽  
Nicole E. Lima ◽  
Tina Lonergan ◽  
Elisa Mokany ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Signal Amplification ◽  
Protein Targets ◽  
Amplification Cascade

Regulation of spontaneous and induced resumption of meiosis in mouse oocytes by different intracellular pathways

Reproduction ◽  
2000 ◽  
pp. 377-383 ◽  
Author(s):  
L Leonardsen ◽  
A Wiersma ◽  
M Baltsen ◽  
AG Byskov ◽  
CY Andersen
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Mitogen Activated Protein Kinase ◽  
Meiotic Maturation ◽  
Mouse Oocytes ◽  
Mitogen Activated Protein ◽  
Dependent Signal ◽  
Kinase Pathway ◽  
Kinase A

The mitogen-activated protein kinase-dependent and the cAMP-protein kinase A-dependent signal transduction pathways were studied in cultured mouse oocytes during induced and spontaneous meiotic maturation. The role of the mitogen-activated protein kinase pathway was assessed using PD98059, which specifically inhibits mitogen-activated protein kinase 1 and 2 (that is, MEK1 and MEK2), which activates mitogen-activated protein kinase. The cAMP-dependent protein kinase was studied by treating oocytes with the protein kinase A inhibitor rp-cAMP. Inhibition of the mitogen-activated protein kinase pathway by PD98059 (25 micromol l(-1)) selectively inhibited the stimulatory effect on meiotic maturation by FSH and meiosis-activating sterol (that is, 4,4-dimethyl-5alpha-cholest-8,14, 24-triene-3beta-ol) in the presence of 4 mmol hypoxanthine l(-1), whereas spontaneous maturation in the absence of hypoxanthine was unaffected. This finding indicates that different signal transduction mechanisms are involved in induced and spontaneous maturation. The protein kinase A inhibitor rp-cAMP induced meiotic maturation in the presence of 4 mmol hypoxanthine l(-1), an effect that was additive to the maturation-promoting effect of FSH and meiosis-activating sterol, indicating that induced maturation also uses the cAMP-protein kinase A-dependent signal transduction pathway. In conclusion, induced and spontaneous maturation of mouse oocytes appear to use different signal transduction pathways.

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