scholarly journals Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells

Oncogene ◽  
2011 ◽  
Vol 30 (37) ◽  
pp. 3930-3942 ◽  
Author(s):  
J-C Cheng ◽  
N Auersperg ◽  
P C K Leung
Keyword(s):  
Tumor Cells ◽  
Promoter Methylation ◽  
Ovarian Tumor ◽  
Dna Methyltransferase ◽  
Borderline Ovarian Tumor ◽  
Dna Methyltransferase 1 ◽  
Ovarian Tumor Cells ◽  
E Cadherin ◽  
Methyltransferase 1

scholarly journals DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma

Cancer ◽  
2005 ◽  
Vol 104 (5) ◽  
pp. 1013-1021 ◽  
Author(s):  
Yi-Shing Shieh ◽  
Shine-Gwo Shiah ◽  
Hao-Hsuan Jeng ◽  
Herng-Sheng Lee ◽  
Cheng-Wen Wu ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Mucoepidermoid Carcinoma ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
E Cadherin ◽  
Methyltransferase 1

SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells

2008 ◽  
Vol 111 (1) ◽  
pp. 125-131 ◽  
Author(s):  
Michelle M. Woo ◽  
Clara M. Salamanca ◽  
Jaime Symowicz ◽  
M. Sharon Stack ◽  
Dianne M. Miller ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ovarian Tumor ◽  
Borderline Ovarian Tumor ◽  
Early Genes ◽  
Ovarian Tumor Cells

scholarly journals Unstable Expression of E-Cadherin Adhesion Molecules in Metastatic Ovarian Tumor Cells

1989 ◽  
Vol 80 (5) ◽  
pp. 459-463 ◽  
Author(s):  
Miwa Hashimoto ◽  
Ohtsura Niwa ◽  
Yumiko Nitta ◽  
Masatoshi Takeichi ◽  
Kenjiro Yokoro
Keyword(s):  
Tumor Cells ◽  
Adhesion Molecules ◽  
Ovarian Tumor ◽  
Ovarian Tumor Cells ◽  
E Cadherin

scholarly journals Characterization of Ascites-Derived Ovarian Tumor Cells from Spontaneously Occurring Ovarian Tumors of the Chicken: Evidence for E-Cadherin Upregulation

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57582 ◽  
Author(s):  
Anupama Tiwari ◽  
Jill A. Hadley ◽  
Gilbert L. Hendricks ◽  
Robert G. Elkin ◽  
Timothy Cooper ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Ovarian Tumor Cells ◽  
E Cadherin

scholarly journals Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications

2007 ◽  
Vol 97 (6) ◽  
pp. 1064-1073 ◽  
Author(s):  
Karen A. Lillycrop ◽  
Jo L. Slater-Jefferies ◽  
Mark A. Hanson ◽  
Keith M. Godfrey ◽  
Alan A. Jackson ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Promoter Methylation ◽  
Dna Methyltransferase ◽  
Metabolic Phenotype ◽  
Dna Methyltransferase 1 ◽  
Gene Promoters ◽  
Dnmt1 Expression ◽  
Methyltransferase 1

Prenatal nutritional constraint induces an altered metabolic phenotype in the offspring which in humans confers an increased risk of non-communicable disease. Feeding a protein-restricted (PR) diet to pregnant rats causes hypomethylation of specific gene promoters in the offspring and alters the phenotype. We investigated how altered epigenetic regulation of the hepatic glucocorticoid receptor (GR) 110 promoter is induced in the offspring. Rats were fed a control (180 g casein/kg) or a PR (90 g casein/kg) diet throughout pregnancy, and chow during lactation. Offspring were killed at postnatal day 34 (n 5 per maternal dietary group). Methylation-sensitive PCR showed that GR110 promoter methylation was 33 % lower (P < 0·001) and GR expression 84 % higher (P < 0·05) in the PR offspring. Reverse transcription–PCR showed that DNA methyltransferase-1 (Dnmt1) expression was 17 % lower (P < 0·05) in PR offspring, while Dnmt3a/b and methyl binding domain protein-2 expression was not altered. Thus hypomethylation of the GR110 promoter may result from lower capacity to methylate hemimethylated DNA during mitosis. Histone modifications which facilitate transcription were increased at the GR110 promoter (147–921 %, P < 0·001), while those that suppress methylation were decreased (54 %, P < 0·01) or similar to controls. In human umbilical cord (n 15), there was a 2-fold difference between the highest and lowest level of GR1-CTotal promoter methylation. Dnmt1, but not Dnmt3a, expression predicted 49 % (P = 0·003) of the variation in GR1-CTotal promoter methylation. These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR110 promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression.

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