scholarly journals The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway

Oncogene ◽  
2011 ◽  
Vol 30 (18) ◽  
pp. 2098-2107 ◽  
Author(s):  
Y Luo ◽  
H Zhou ◽  
L Liu ◽  
T Shen ◽  
W Chen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Signaling Pathway ◽  
Lymphatic Endothelial Cell ◽  
Tube Formation ◽  
Erk Signaling

scholarly journals Cryptotanshinone Inhibits Lymphatic Endothelial Cell Tube Formation by Suppressing VEGFR-3/ERK and Small GTPase Pathways

2011 ◽  
Vol 4 (12) ◽  
pp. 2083-2091 ◽  
Author(s):  
Yan Luo ◽  
Wenxing Chen ◽  
Hongyu Zhou ◽  
Lei Liu ◽  
Tao Shen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Tube Formation ◽  
Small Gtpase

Dihydroartemisinin inhibits endothelial cell proliferation through the suppression of the ERK signaling pathway

2015 ◽  
Vol 35 (5) ◽  
pp. 1381-1387 ◽  
Author(s):  
FENGYUN DONG ◽  
HU TIAN ◽  
SUHUA YAN ◽  
LIQUN LI ◽  
XIAOFENG DONG ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Signaling Pathway ◽  
Erk Signaling ◽  
Endothelial Cell Proliferation

scholarly journals Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158408 ◽  
Author(s):  
Akinori Sato ◽  
Ryuta Kamekura ◽  
Koji Kawata ◽  
Masaya Kawada ◽  
Sumito Jitsukawa ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Tube Formation ◽  
Cell Homeostasis

scholarly journals Ginsenoside Rg1-Notoginsenoside R1-Protocatechuic Aldehyde Reduces Atherosclerosis and Attenuates Low-Shear Stress-Induced Vascular Endothelial Cell Dysfunction

2021 ◽  
Vol 11 ◽  
Author(s):  
Lei Zhang ◽  
Yuan Li ◽  
Xin Ma ◽  
Jiali Liu ◽  
Xiaojie Wang ◽  
...  
Keyword(s):  
Shear Stress ◽  
Endothelial Cell ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Tube Formation ◽  
Vascular Endothelial ◽  
Ginsenoside Rg1 ◽  
Akt Signaling Pathway ◽  
Low Shear Stress ◽  
Low Shear

Background: The Fufang Danshen formula is a clinically important anti-atherosclerotic preparation in traditional Chinese medicine. However, its anti-atherosclerotic effect is not well recognized, and the mechanisms of its combined active ingredients, namely Ginsenoside Rg1-Notoginsenoside R1-Protocatechuic aldehyde (RRP), remain unclear. The purpose of this study was to investigate the anti-atherosclerotic effects and potential mechanism of RRP in ApoE−/− mice and in low-shear stress-injured vascular endothelial cells.Methods: ApoE−/− mice were randomly divided into three groups: model group, rosuvastatin group, and RRP group, with C57BL/6J mice as the control group. Oil-red O, hematoxylin and eosin, Masson, and Movat staining were utilized for the observation of aortic plaque. Changes in the blood lipid indexes were observed with an automatic biochemistry analyzer. ET-1, eNOS, TXA2, and PGI2 levels were analyzed by enzyme-linked immunosorbent assay. In vitro, a fluid shear stress system was used to induce cell injury. Piezo1 expression in HUVECs was silenced using siRNA. Changes in morphology, proliferation, migration, and tube formation activity of cells were observed after RRP treatment. Quantitative Real-Time PCR and western blot analysis were employed to monitor mRNA and protein expression.Results: RRP treatment reduced the atherosclerotic area and lipid levels and improved endothelial function in ApoE−/− mice. RRP significantly repaired cell morphology, reduced excessive cell proliferation, and ameliorated migration and tube formation activity. In addition, RRP affected the FAK-PI3K/Akt signaling pathway. Importantly, Piezo1 silencing abolished the protective effects of RRP.Conclusion: RRP has anti-atherosclerotic effects and antagonizes endothelial cell damage via modulating the FAK-PI3K/Akt signaling pathway. Piezo1 is a possible target of RRP in the treatment of atherosclerosis. Thus, RRP has promising therapeutic potential and broad application prospect for atherosclerosis.

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