scholarly journals Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W)

Oncogene ◽  
2010 ◽  
Vol 30 (14) ◽  
pp. 1653-1663 ◽  
Author(s):  
J-H Kim ◽  
S Yoon ◽  
M Park ◽  
H-O Park ◽  
J-J Ko ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Wild Type ◽  
Adult Type

scholarly journals Adult‐type granulosa cell tumor of the ovary: a FOXL2 ‐centric disease

2021 ◽  
Author(s):  
Jessica A Pilsworth ◽  
Dawn R Cochrane ◽  
Samantha J Neilson ◽  
Bahar H Moussavi ◽  
Daniel Lai ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Adult Type

scholarly journals Testicular Adult Type Granulosa Cell Tumor: A Very Rare Case Report and Review of Literature

2017 ◽  
Vol 1 (1) ◽  
pp. 12-14 ◽  
Author(s):  
Wei-Chieh Chen ◽  
◽  
Yun-Ho Lin ◽  
Shauh-Der Yeh ◽  
Chien-Chih Wu ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Rare Case ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of Literature ◽  
Adult Type ◽  
Rare Case Report

Abstract B10: FOXL2 402C>G mutation can be identified in the circulating tumor DNA of patients with adult-type granulosa cell tumor.

2016 ◽  
Author(s):  
Anniina Färkkilä ◽  
Melissa K. McConechy ◽  
Winnie Yang ◽  
Aline Talhouk ◽  
Ying Ng ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Circulating Tumor Dna ◽  
Cell Tumor ◽  
Adult Type ◽  
Tumor Dna

scholarly journals Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Dan Zhao ◽  
Yanan Zhang ◽  
Zhengjie Ou ◽  
Rong Zhang ◽  
Shan Zheng ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Treatment Results ◽  
Adult Type

scholarly journals Adult type granulosa cell tumor in adult testis: report of a case and review of the literature

Rare Tumors ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 117-119 ◽  
Author(s):  
Zhao Song ◽  
David J. Vaughn ◽  
Zhanyong Bing
Keyword(s):  
Alkaline Phosphatase ◽  
Granulosa Cell ◽  
Epithelial Membrane Antigen ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Type ◽  
Adult Testis ◽  
Granulosa Cell Tumors ◽  
Hmb 45

Granulosa cell tumors can be classified into juvenile and adult types and more commonly occur in ovaries. Adult testicular granulosa cell tumors are extremely rare and only 29 cases of adult type have previously been reported. We report here a 28-year old Caucasian man with a left testicular adult type granulosa cell tumor. The tumor measured 2.6×2.6×2.5 cm and was mitotically active (10/10 HPF). Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin, and negative for epithelial membrane antigen, cytokeratins, synaptophysin, HMB-45, OCT-4, placental-like alkaline phosphatase and lymphoid markers. The reported granulosa cell tumors in adult testis were briefly reviewed.

FOXL2 Mutations in Granulosa Cell Tumors Occurring in Males

2012 ◽  
Vol 136 (7) ◽  
pp. 825-828 ◽  
Author(s):  
Joema F. Lima ◽  
Long Jin ◽  
Ana Rose C. de Araujo ◽  
Michele R. Erikson-Johnson ◽  
Andre M. Oliveira ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Leydig Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Adult Type ◽  
Male Adult ◽  
Granulosa Cell Tumors ◽  
Juvenile Granulosa Cell Tumor ◽  
Leydig Cell Tumors

Context.—Granulosa cell tumors comprise less than 5% of ovarian tumors in women and are much rarer in men, with only about 20 cases reported, to our knowledge. Recently, a somatic mutation of FOXL2 was reported in virtually all adult-type granulosa cell tumors in women. Objective.—To investigate FOXL2 mutations in granulosa cell tumors occurring in males. Design.—Five cases of an adult-type granulosa cell tumor from males were selected from the files of the Mayo Clinic. Nine other testicular tumors (1 juvenile granulosa cell tumor, 5 Leydig cell tumors, and 3 Sertoli-Leydig cell tumors) were evaluated for comparison. Inhibin immunostain was performed in all cases. DNA was extracted from formalin-fixed, paraffin-embedded tissue, followed by polymerase chain reaction and direct sequencing of FOXL2. Results.—All 5 cases had classic histopathologic features of the adult-type granulosa cell tumor. Inhibin was diffusely positive in all cases. FOXL2 402C→G (C134W) was identified in 40% (2 of 5) of the male, adult-type granulosa cell tumors. Of the 2 tumors positive for the mutation, 1 occurred in the testis of a man, and the other one affected the abdominal ovaries of a phenotypically male patient. All other testicular tumors were negative for the mutation. Conclusions.—The FOXL2 402C→G (C134W) mutation is also present in adult-type granulosa cell tumors occurring in men, although in a smaller proportion when compared with the rates reported in women. FOXL2 mutational analysis can be a helpful in the diagnosis of granulosa cell tumors of the testis.

Adult Type Testicular Granulosa Cell Tumor: Case Report and Review of the Literature

2006 ◽  
Vol 73 (3) ◽  
pp. 297-301
Author(s):  
G. Lucarelli ◽  
V. Mancini ◽  
G. Annunziata ◽  
S. Trabucco ◽  
S. Palazzo ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Type

scholarly journals Extraovarian Granulosa Cell Tumor of Mesentery: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Manjiri R. Naniwadekar ◽  
N. J. Patil
Keyword(s):  
Granulosa Cell ◽  
Histopathological Examination ◽  
Previous History ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Genital Ridge ◽  
Adult Type ◽  
Mesenteric Mass ◽  
History Of ◽  
Ovary Tumor

Extraovarian granulosa cell tumor (GCT) is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. A 54 years old female patient presented with a mass and acute pain in abdomen. Exploratory laparatomy revealed hemoperitoneum with a large mesenteric mass measuring 13 × 12 cm in size, showing extensive areas of haemorrhages. Histopathological examination of the excised mass showed features of adult-type GCT. As the patient had a history of hysterectomy with bilateral salpingo-oophorectomy 10 years ago for ‘‘leiomyoma’’ with no evidence of GCT of the ovary in the histopathology report, a diagnosis of extraovarian GCT was made. A diagnosis of extraovarian GCT should be carried out after excluding any previous history of GCT of the ovary. Tumor rupture with haemoperitoneum is a well-known complication of GCT. Extraovarian GCT is a rare tumor with only 10 cases reported in literature. The case is presented for its rarity.

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