scholarly journals Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

Oncogene ◽  
2010 ◽  
Vol 30 (4) ◽  
pp. 482-493 ◽  
Author(s):  
S Sengupta ◽  
A K Mantha ◽  
S Mitra ◽  
K K Bhakat
Keyword(s):  
Multidrug Resistance ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Resistance Gene ◽  
Multidrug Resistance Gene ◽  
Drug Induced ◽  
Ap Endonuclease ◽  
P300 Recruitment

scholarly journals Regulatory Role of Human AP-Endonuclease (APE1/Ref-1) in YB-1-Mediated Activation of the Multidrug Resistance Gene MDR1

2008 ◽  
Vol 28 (23) ◽  
pp. 7066-7080 ◽  
Author(s):  
Ranajoy Chattopadhyay ◽  
Soumita Das ◽  
Amit K. Maiti ◽  
Istvan Boldogh ◽  
Jingwu Xie ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Tumor Cells ◽  
Regulatory Function ◽  
Cancer Tissue ◽  
Multidrug Resistance Gene ◽  
Ap Endonuclease ◽  
Transcriptional Regulatory

ABSTRACT Human AP-endonuclease (APE1/Ref-1), a central enzyme involved in the repair of oxidative base damage and DNA strand breaks, has a second activity as a transcriptional regulator that binds to several trans-acting factors. APE1 overexpression is often observed in tumor cells and confers resistance to various anticancer drugs; its downregulation sensitizes tumor cells to such agents. Because the involvement of APE1 in repairing the DNA damage induced by many of these drugs is unlikely, drug resistance may be linked to APE1's transcriptional regulatory function. Here, we show that APE1, preferably in the acetylated form, stably interacts with Y-box-binding protein 1 (YB-1) and enhances its binding to the Y-box element, leading to the activation of the multidrug resistance gene MDR1. The enhanced MDR1 level due to the ectopic expression of wild-type APE1 but not of its nonacetylable mutant underscores the importance of APE1's acetylation in its coactivator function. APE1 downregulation sensitizes MDR1-overexpressing tumor cells to cisplatin or doxorubicin, showing APE1's critical role in YB-1-mediated gene expression and, thus, drug resistance in tumor cells. A systematic increase in both APE1 and MDR1 expression was observed in non-small-cell lung cancer tissue samples. Thus, our study has established the novel role of the acetylation-mediated transcriptional regulatory function of APE1, making it a potential target for the drug sensitization of tumor cells.

Expression of a Multidrug Resistance Gene in Blast Crisis of Chronic Myelogenous Leukemia

1989 ◽  
Vol 1 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Robert Pirker ◽  
Lori J. Goldstein ◽  
Heinz Ludwig ◽  
Werner Linkesch ◽  
Christina Lechner ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Chronic Myelogenous Leukemia ◽  
Blast Crisis ◽  
Myelogenous Leukemia ◽  
Multidrug Resistance Gene

Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats

Life Sciences ◽  
2021 ◽  
pp. 119603
Author(s):  
Ping Wangs ◽  
Yan Chen ◽  
La-Mei Zhang ◽  
Si-Qi Yuan ◽  
Shen-Ao Lu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Multidrug Resistance Gene

scholarly journals Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

1989 ◽  
Vol 264 (30) ◽  
pp. 18031-18040
Author(s):  
L A Mickley ◽  
S E Bates ◽  
N D Richert ◽  
S Currier ◽  
S Tanaka ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Multidrug Resistance Gene ◽  
P Glycoprotein ◽  
Differentiating Agents ◽  
Mdr 1

The biological significance of the multidrug resistance gene MRP in inversion 16 leukemias

1996 ◽  
Vol 20 (5-6) ◽  
pp. 357-364 ◽  
Author(s):  
Bryone J. Kuss ◽  
Roger G. Deeley ◽  
Susan P. C. Cole ◽  
Cheryl L. Willman ◽  
Kenneth J. Kopecky ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Biological Significance ◽  
Multidrug Resistance Gene

scholarly journals Structural Biology of Bacterial Multidrug Resistance Gene Regulators

2002 ◽  
Vol 277 (43) ◽  
pp. 40169-40172 ◽  
Author(s):  
Michael H. Godsey ◽  
Ekaterina E. Zheleznova Heldwein ◽  
Richard G. Brennan
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Structural Biology ◽  
Multidrug Resistance Gene
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