scholarly journals The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma

Oncogene ◽  
2010 ◽  
Vol 29 (46) ◽  
pp. 6138-6148 ◽  
Author(s):  
L B C Bralten ◽  
A M Gravendeel ◽  
N K Kloosterhof ◽  
A Sacchetti ◽  
T Vrijenhoek ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Suppressor Gene

scholarly journals Neural Cell Adhesion Molecule (NCAM) and Deleted in Colorectal Carcinomas (DCC) Tumor Suppressor Gene.

1994 ◽  
Vol 27 (10) ◽  
pp. 2308-2311
Author(s):  
Yoshihiko Hiramoto ◽  
Akira Gouchi ◽  
Masafumi Kataoka ◽  
Takahiro Okabayashi ◽  
Takatoshi Yamada ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Suppressor Gene ◽  
Neural Cell ◽  
Colorectal Carcinomas ◽  
Neural Cell Adhesion

Generation of a monoclonal antibody specific to a new candidate tumor suppressor, cell adhesion molecule 2

Tumor Biology ◽  
2014 ◽  
Vol 35 (8) ◽  
pp. 7415-7422 ◽  
Author(s):  
Meijin Huang ◽  
Ziyuan Xia ◽  
Yang Wang ◽  
Liang Huang ◽  
Qian Ma ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cell Adhesion ◽  
Tumor Suppressor ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Suppressor Cell ◽  
Candidate Tumor Suppressor

scholarly journals Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion

2011 ◽  
Vol 32 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Kalyani Ruthala ◽  
Jogeswar Gadi ◽  
Ji-Yeon Lee ◽  
Heejei Yoon ◽  
Hyun Joo Chung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Adhesion ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

scholarly journals The Role of Cell Adhesion Molecule 1 (CADM1) in Cutaneous Malignancies

2020 ◽  
Vol 21 (24) ◽  
pp. 9732
Author(s):  
Yu Sawada ◽  
Emi Mashima ◽  
Natsuko Saito-Sasaki ◽  
Motonobu Nakamura
Keyword(s):  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Adhesion Molecule ◽  
Immune Cells ◽  
Cell Adhesion Molecule ◽  
Tumor Development ◽  
Suppressor Gene ◽  
Cutaneous Lymphomas ◽  
Cell Adhesion Molecule 1

Cell adhesion ability is one of the components to establish cell organization and shows a great contribution to human body construction consisting of various types of cells mixture to orchestrate tissue specific function. The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. However, little is known about the function of CADM1 on cutaneous cells and cutaneous malignancies. CADM1 plays an important role in connecting cells with each other, contacting cells to deliver their signal, and acting as a scaffolding molecule for other immune cells to develop their immune responses. A limited number of studies reveal the contribution of CADM1 on the development of cutaneous malignancies. Solid cutaneous malignancies, such as cutaneous squamous cell carcinoma and malignant melanoma, reduce their CADM1 expression to promote the invasion and metastasis of the tumor. On the contrary to these cutaneous solid tumors except for Merkel cell carcinoma, cutaneous lymphomas, such as adult-T cell leukemia/lymphoma, mycosis fungoides, and Sézary syndrome, increase their CADM1 expression for the development of tumor environment. Based on the role of CADM1 in the etiology of tumor development, the theory of CADM1 contribution will desirably be applied to skin tumors according to other organ malignancies, however, the characteristics of skin as a multicomponent peripheral organ should be kept in mind to conclude their prognoses.

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