scholarly journals Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth

Oncogene ◽  
2010 ◽  
Vol 29 (38) ◽  
pp. 5286-5298 ◽  
Author(s):  
A R Cantelmo ◽  
R Cammarota ◽  
D M Noonan ◽  
C Focaccetti ◽  
P M Comoglio ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Vascular Tumor ◽  
Cell Delivery ◽  
Docking Site

A continuum description of vascular tumor growth

2017 ◽  
Author(s):  
Anna Claudia M. Resende ◽  
Regina C. Almeida ◽  
Ernesto A. B. F. Lima ◽  
Brendon J. Rodrigues
Keyword(s):  
Tumor Growth ◽  
Vascular Tumor ◽  
Continuum Description

Mechanistic modeling of vascular tumor growth: an extension of Biot’s theory to hierarchical bi-compartment porous medium system

2020 ◽  
Author(s):  
Giuseppe Sciumè
Keyword(s):  
Porous Medium ◽  
Tumor Growth ◽  
Growth Models ◽  
Numerical Study ◽  
Vascular Tumor ◽  
Mechanistic Modeling ◽  
Fluid Mixture ◽  
Tumor Growth Models ◽  
Definition Of ◽  
External Loads

AbstractExisting continuum multiphase tumor growth models typically do not include microvasculature, or if present, this is modeled as non-deformable. Vasculature behavior and blood flow are usually non-coupled with the underlying tumor phenomenology from the mechanical viewpoint; hence, phenomena as vessel compression/occlusion modifying microcirculation and oxygen supply cannot be taken into account.The tumor tissue is here modeled as a reactive bi-compartment porous medium: the extracellular matrix constitutes the solid scaffold; blood is in the vascular porosity whereas the extra-vascular porous compartment is saturated by two cell phases and interstitial fluid (mixture of water and nutrient species). The pressure difference between blood and the extra-vascular overall pressure is sustained by vessel walls and drives shrinkage or dilatation of the vascular porosity. Model closure is achieved thanks to a consistent non-conventional definition of the Biot’s effective stress tensor.Angiogenesis is modeled by introducing a vascularization state variable, and accounting for tumor angiogenic factors and endothelial cells. Closure relationships and mass exchange terms related to vessel formation are detailed in a numerical example reproducing the principal features of angiogenesis. This example is preceded by a first pedagogical numerical study on one-dimensional bio-consolidation. Results are exquisite to realize that the bi-compartment poromechanical model is fully coupled (the external loads impact fluid flow in both porous compartments) and to envision further applications as for instance modeling of drugs delivery and tissue ulceration.

365 Cell delivery of the Met docking site peptide inhibits angiogenesis and vascular tumour growth

2010 ◽  
Vol 8 (5) ◽  
pp. 93
Author(s):  
A.R. Cantelmo ◽  
R. Cammarota ◽  
D.M. Noonan ◽  
C. Focaccetti ◽  
P.M. Comoglio ◽  
...  
Keyword(s):  
Tumour Growth ◽  
Cell Delivery ◽  
Docking Site ◽  
Vascular Tumour

Toward Predictive Multiscale Modeling of Vascular Tumor Growth

2015 ◽  
Vol 23 (4) ◽  
pp. 735-779 ◽  
Author(s):  
J. Tinsley Oden ◽  
Ernesto A. B. F. Lima ◽  
Regina C. Almeida ◽  
Yusheng Feng ◽  
Marissa Nichole Rylander ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Multiscale Modeling ◽  
Vascular Tumor
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