scholarly journals A B56γ mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A

Oncogene ◽  
2010 ◽  
Vol 29 (27) ◽  
pp. 3933-3941 ◽  
Author(s):  
G P Shouse ◽  
Y Nobumori ◽  
X Liu
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Tumor Suppressor Function ◽  
Suppressor Function ◽  
Phosphatase 2A

Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1

2016 ◽  
Vol 44 (6) ◽  
pp. 1683-1693 ◽  
Author(s):  
Amanpreet Kaur ◽  
Jukka Westermarck
Keyword(s):  
Tumor Suppressor ◽  
Protein Phosphatase ◽  
Kinase Inhibitor ◽  
Protein Phosphatase 2A ◽  
Signaling Proteins ◽  
Tumor Suppressor Function ◽  
Phosphatase 2A ◽  
Cancer Types ◽  
Associated Function ◽  
Inhibitor Resistance

Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.

scholarly journals Protein Phosphatase 2A Regulatory Subunit B56α Associates with c-Myc and Negatively Regulates c-Myc Accumulation

2006 ◽  
Vol 26 (7) ◽  
pp. 2832-2844 ◽  
Author(s):  
Hugh K. Arnold ◽  
Rosalie C. Sears
Keyword(s):  
Tumor Suppressor ◽  
Protein Phosphatase ◽  
Cell Function ◽  
Cell Transformation ◽  
Protein Phosphatase 2A ◽  
Regulatory Subunit ◽  
Suppressor Activity ◽  
Tumor Suppressor Activity ◽  
Structural Subunit ◽  
Phosphatase 2A

ABSTRACT Protein phosphatase 2A (PP2A) plays a prominent role in controlling accumulation of the proto-oncoprotein c-Myc. PP2A mediates its effects on c-Myc by dephosphorylating a conserved residue that normally stabilizes c-Myc, and in this way, PP2A enhances c-Myc ubiquitin-mediated degradation. Stringent regulation of c-Myc levels is essential for normal cell function, as c-Myc overexpression can lead to cell transformation. Conversely, PP2A has tumor suppressor activity. Uncovering relevant PP2A holoenzymes for a particular target has been limited by the fact that cellular PP2A represents a large heterogeneous population of trimeric holoenzymes, composed of a conserved catalytic subunit and a structural subunit along with a variable regulatory subunit which directs the holoenzyme to a specific target. We now report the identification of a specific PP2A regulatory subunit, B56α, that selectively associates with the N terminus of c-Myc. B56α directs intact PP2A holoenzymes to c-Myc, resulting in a dramatic reduction in c-Myc levels. Inhibition of PP2A-B56α holoenzymes, using small hairpin RNA to knock down B56α, results in c-Myc overexpression, elevated levels of c-Myc serine 62 phosphorylation, and increased c-Myc function. These results uncover a new protein involved in regulating c-Myc expression and reveal a critical interconnection between a potent oncoprotein, c-Myc, and a well-documented tumor suppressor, PP2A.

Protein phosphatase 2A is essential to maintain active Wnt signaling and its Aβ tumor suppressor subunit is not expressed in colon cancer cells

2014 ◽  
Vol 54 (11) ◽  
pp. 1430-1441 ◽  
Author(s):  
M. Carmen Figueroa-Aldariz ◽  
M. Cristina Castañeda-Patlán ◽  
Paula Santoyo-Ramos ◽  
Alejandro Zentella ◽  
Martha Robles-Flores
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Colon Cancer Cells ◽  
Phosphatase 2A

Abstract 5329: Development of small molecule activators of protein phosphatase 2A for the treatment of lung cancer

2015 ◽  
Author(s):  
Jaya Sangodkar ◽  
Sudeh Izadmehr ◽  
Sahar Mahzar ◽  
Divya Hoon ◽  
Shen Yao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Molecule ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Phosphatase 2A

Abstract 3865: Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer

2016 ◽  
Author(s):  
Jaya Sangodkar ◽  
Rita Tohme ◽  
Janna Kiselar ◽  
Sudeh Izadmehr ◽  
Divya Hoon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Phosphatase 2A

scholarly journals Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 21510-21526 ◽  
Author(s):  
Cheng-Cao Sun ◽  
Shu-Jun Li ◽  
Feng Zhang ◽  
Jing-Yu Pan ◽  
Liang Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Tumor Suppressor Function ◽  
Small Cell Lung ◽  
Down Regulation ◽  
Suppressor Function
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