scholarly journals Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells

Oncogene ◽  
2009 ◽  
Vol 29 (1) ◽  
pp. 117-127 ◽  
Author(s):  
P Nirdé ◽  
D Derocq ◽  
M Maynadier ◽  
M Chambon ◽  
I Basile ◽  
...  
Keyword(s):  
Heat Shock ◽  
Cancer Cells ◽  
Protein Secretion ◽  
Growth Arrest ◽  
Heat Shock Cognate 70

Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells

2004 ◽  
Vol 14 (4) ◽  
pp. 616-620 ◽  
Author(s):  
Y. Tanaka ◽  
K. Fujiwara ◽  
H. Tanaka ◽  
K. Maehata ◽  
I. Kohno
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Cell Lines ◽  
Uterine Cancer ◽  
Gynecologic Cancer ◽  
Flow Cytometric Analysis ◽  
Growth Arrest ◽  
Heat Shock Protein 27 ◽  
Ovarian Cancer Cells

The purpose of the study was to determine whether paclitaxel inhibits the expression of heat shock protein 27 (HSP27) in two gynecologic cancer cell lines compared with other antineoplastic agents having different cytotoxic mechanisms. BG-1 ovarian cancer cells and HeLa uterine cancer cells were treated with a tubulin depolymerization inhibitor (paclitaxel), a topoisomerase-II inhibitor (etoposide), and two tubulin polymerization inhibitors (colcemid and vincristine). Cell kills were evaluated by counting the number of cells. Propidium iodide staining and flow cytometric analysis were applied for the determination of cell-cycle perturbation. HSP27 was stained by the indirect immunofluorescence technique and analyzed with a flow cytometer. In both BG-1 and HeLa cells, growth arrest and G2/M accumulation were dependent on the dose of each cytotoxic agent. There were positive correlations between HSP27 overexpression and growth arrest and G2/M accumulation when the cell lines were treated with etoposide, colcemid, or vincristine, but not with paclitaxel. Paclitaxel completely inhibited the expression of HSP27. The results of this study indicated that paclitaxel may possess unique mechanisms able to overcome drug resistance by inhibiting HSP27 expression.

scholarly journals Inhibition of REV3 Expression Induces Persistent DNA Damage and Growth Arrest in Cancer Cells

Neoplasia ◽  
2011 ◽  
Vol 13 (10) ◽  
pp. 961-IN28 ◽  
Author(s):  
Philip A. Knobel ◽  
Ilya N. Kotov ◽  
Emanuela Felley-Bosco ◽  
Rolf A. Stahel ◽  
Thomas M. Marti
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Growth Arrest

scholarly journals Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15288 ◽  
Author(s):  
Qinghe Chen ◽  
Suthakar Ganapathy ◽  
Karan P. Singh ◽  
Sharmila Shankar ◽  
Rakesh K. Srivastava
Keyword(s):  
Prostate Cancer ◽  
Transcription Factors ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Prostate Cancer Cells ◽  
Foxo Transcription Factors

On the Mechanisms of 12-Otetradecanoylphorbol-13-acetate-induced Growth Arrest in Pancreatic Cancer Cells

Pancreas ◽  
2006 ◽  
Vol 33 (2) ◽  
pp. 148-155 ◽  
Author(s):  
Mohammad R. Salabat ◽  
Xian Z. Ding ◽  
Jan B. Flesche ◽  
Micheal B. Ujiki ◽  
Tyler P. Robin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Pancreatic Cancer Cells

Elevated levels of intracellular Ca 2+ and apoptosis in human lung cancer cells given heat-shock

2003 ◽  
Vol 19 (2) ◽  
pp. 178-192 ◽  
Author(s):  
T. Hashimoto ◽  
M-A. Shibata ◽  
Y. Ito ◽  
K.-I. Nakao ◽  
S. Sasaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Heat Shock ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Intracellular Ca
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