scholarly journals Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire

Oncogene ◽  
2009 ◽  
Vol 28 (47) ◽  
pp. 4162-4174 ◽  
Author(s):  
I H Chan ◽  
M L Privalsky
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Target Gene ◽  
Thyroid Hormone Receptor ◽  
Human Hepatocellular Carcinoma ◽  
Gene Repertoire

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

Nature ◽  
1987 ◽  
Vol 330 (6149) ◽  
pp. 667-670 ◽  
Author(s):  
Hugues de Thé ◽  
Agnès Marchio ◽  
Pierre Tiollais ◽  
Anne Dejean
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Human Hepatocellular Carcinoma ◽  
Related Gene

scholarly journals Negative Regulation of TSHα Target Gene by Thyroid Hormone Involves Histone Acetylation and Corepressor Complex Dissociation

2009 ◽  
Vol 23 (5) ◽  
pp. 600-609 ◽  
Author(s):  
Dongqing Wang ◽  
Xianmin Xia ◽  
Ying Liu ◽  
Alexis Oetting ◽  
Robert L. Walker ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Histone Acetylation ◽  
Chromatin Immunoprecipitation ◽  
Hormone Receptor ◽  
Target Gene ◽  
Thyroid Hormone Receptor ◽  
Critical Role ◽  
Negative Regulation ◽  
Pituitary Cells ◽  
Corepressor Complex

Abstract Currently, little is known about histone modifications and molecular mechanisms of negatively regulated transcription. In pituitary cells, thyroid hormone (T3) decreased transcription, and surprisingly increased histone acetylation, of TSHα promoter. This increase was mediated directly by thyroid hormone receptor. Histone acetylation of H3K9 and H3K18 sites, two modifications usually associated with transcriptional activation, occur in negative regulation of TSHα promoter. T3 also caused release of a corepressor complex composed of histone deacetylase 3 (HDAC3), transducin β-like protein 1, and nuclear receptor coprepressor (NCoR)/ silencing mediator for retinoic and thyroid hormone receptor from TSHα promoter in chromatin immunoprecipitation assays. NCoR and HDAC3 overexpression selectively increased ligand-independent basal transcription. Two histone acetyltransferase inhibitors increased overall transcription but did not abrogate negative regulation or NCoR/HDAC3 complex release by T3. Chromatin immunoprecipitation analyses of an endogenous positively regulated target gene showed increased histone acetylation and corepressor complex release with T3 treatment. Finally, microarray analyses suggested there is a subset of negatively regulated genes with increased histone acetylation. These findings demonstrate the critical role of NCoR/HDAC3 complex in negative regulation of TSHα gene expression and show that similar complexes and overlapping epigenetic modifications can participate in both negative and positive transcriptional regulation.

scholarly journals Thyroid Hormone Receptor β (THRB) Is a Major Target Gene for Micro-RNAs Deregulated in Papillary Thyroid Carcinoma (PTC)

2011 ◽  
Vol 32 (1) ◽  
pp. 157-157
Author(s):  
Krystian Jazdzewski ◽  
Joanna Boguslawska ◽  
Jaroslaw Jendrzejewski ◽  
Sandya Liyanarachchi ◽  
Janusz Pachucki ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Hormone Receptor ◽  
Target Gene ◽  
Thyroid Hormone Receptor ◽  
Papillary Thyroid ◽  
Micro Rnas ◽  
Thyroid Hormone Receptor Β ◽  
Major Target

GAR22: A novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells

2009 ◽  
Vol 37 (5) ◽  
pp. 539-548.e4 ◽  
Author(s):  
Ivonne Gamper ◽  
Ki-Ryang Koh ◽  
David Ruau ◽  
Katrin Ullrich ◽  
Jana Bartunkova ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Growth Inhibition ◽  
Hormone Receptor ◽  
Target Gene ◽  
Thyroid Hormone Receptor ◽  
Erythroid Cells ◽  
Novel Target
Sign in / Sign up

Export Citation Format

Share Document