scholarly journals Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

Oncogene ◽  
2009 ◽  
Vol 28 (45) ◽  
pp. 3983-3996 ◽  
Author(s):  
A Arlt ◽  
I Bauer ◽  
C Schafmayer ◽  
J Tepel ◽  
S Sebens Müerköster ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Expression ◽  
Proteasome Activity ◽  
Related Factor ◽  
Nuclear Factor ◽  
Proteasome Subunit ◽  
Subunit Protein

scholarly journals Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells

2015 ◽  
Vol 10 (3) ◽  
pp. 1287-1292 ◽  
Author(s):  
XIAO-QIAN ZHAO ◽  
YI-FEI ZHANG ◽  
YI-FANG XIA ◽  
ZHONG-MEI ZHOU ◽  
YING-QING CAO
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Related Factor ◽  
Nuclear Factor ◽  
Drug Resistant ◽  
Colon Cancer Cells

scholarly journals Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue

2015 ◽  
Vol 27 (5) ◽  
pp. 507 ◽  
Author(s):  
Yoon Jin Lee ◽  
Sun Bum Kwon ◽  
Chul Han Kim ◽  
Hyun Deuk Cho ◽  
Hae Seon Nam ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protein Expression ◽  
Normal Skin ◽  
Related Factor ◽  
Nuclear Factor

scholarly journals Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells

Antioxidants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 285 ◽  
Author(s):  
Da-Young Lee ◽  
Sun-Mi Yun ◽  
Moon-Young Song ◽  
Kiwon Jung ◽  
Eun-Hee Kim
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Cellular Proliferation ◽  
Biological Effects ◽  
Developed Countries ◽  
Related Factor ◽  
Nuclear Factor ◽  
Colorectal Cancer Cells

Colorectal cancer (CRC) is the third most common cancer worldwide and a leading cause of cancer-related deaths in developed countries. Anthocyanins are a class of flavonoids, widely distributed in food, exhibiting important biological effects. Cyanidin chloride (CyCl) is the common type of anthocyanin with antioxidative and anti-inflammatory potential. The present study aimed to investigate the molecular mechanisms underlying the chemotherapeutic effects of CyCl in colorectal cancer cells. We found that CyCl treatment induced apoptosis as well as a significant inhibition of cellular proliferation and colony formation in three colon cancer HCT116, HT29, and SW620 cells. In addition, CyCl suppressed nuclear factor-kappa B (NF-κB) signaling and induced the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in tumor necrosis factor-alpha (TNF-α)-stimulated colon cancer cells. Nrf2 and NF-κB are two key transcription factors regulating antioxidative responses and cellular proliferation, respectively. In this study, knockdown of Nrf2 by small interfering RNA (siRNA) transfection inhibited the effect of CyCl on NF-κB signaling and apoptosis, suggesting that there is functional crosstalk between Nrf2 and NF-κB. Our findings demonstrate the important role of Nrf2 in inducing apoptosis through the involvement of NF-κB signaling in colorectal cancer cells, suggesting that CyCl may be used as a potential therapeutic agent for CRC.

Oxidative damage and Nrf2 (nuclear factor erythroid 2-related factor 2) protein expression in normal skin and keloid tissues

2016 ◽  
Vol 84 (1) ◽  
pp. e111
Author(s):  
Kyu Uang Whang ◽  
Jong Suk Lee ◽  
Sung Yul Lee ◽  
Je Min An ◽  
Kyung O. Kim ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protein Expression ◽  
Normal Skin ◽  
Related Factor ◽  
Nuclear Factor
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