scholarly journals MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation

Oncogene ◽  
2009 ◽  
Vol 28 (38) ◽  
pp. 3360-3370 ◽  
Author(s):  
K-H Lee ◽  
Y-L Chen ◽  
S-D Yeh ◽  
M Hsiao ◽  
J-T Lin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Akt Phosphorylation

scholarly journals Crosstalk between Prostate Cancer Cells and Tumor-Associated Fibroblasts Enhances the Malignancy by Inhibiting the Tumor Suppressor PLZF

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1083
Author(s):  
Kum Hee Noh ◽  
Ae Jin Jeong ◽  
Haeri Lee ◽  
Song-Hee Lee ◽  
Eunhee Yi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Tyrosine Phosphatase ◽  
Migration And Invasion ◽  
Metastatic Progression ◽  
Prostate Cancer Cells ◽  
Prostate Cancer Metastasis

Although prostate cancer is clinically manageable during the early stages of progression, metastatic progression severely compromises the prognosis and leads to mortality. Constitutive activation of STAT3 has been connected to prostate cancer malignancy, and abolishing the STAT3 activity may diminish tumor growth and metastasis. However, its suppressor genes and pathways have not been well established. In this study, we show that promyelocytic leukemia zinc finger (PLZF) has a putative tumor-suppressor function in prostate cancer by inhibiting phosphorylation of STAT3. Compared with a benign prostate, high-grade prostate cancer patient tissue was negatively correlated with PLZF expression. PLZF depletion accelerated proliferation and survival, migration, and invasion in human prostate cancer cells. Mechanistically, we demonstrated a novel role of PLZF as the transcriptional regulator of the tyrosine phosphatase SHP-1 that inhibits the oncogenic JAKs–STAT3 pathway. These results suggest that the collapse of PLZF expression by the CCL3 derived from fibroblasts accelerates the cell migration and invasion properties of prostate cancer cells. Our results suggest that increasing PLZF could be an attractive strategy for suppressing prostate cancer metastasis as well as for tumor growth.

MITOSTATIN, A NOVEL MITOCHONDRIAL PROTEIN, THAT ACTS AS A TUMOR SUPPRESSOR IN PROSTATE CANCER CELLS

2008 ◽  
Vol 179 (4S) ◽  
pp. 458-458
Author(s):  
Matteo Fassan ◽  
Domenico D'Arca ◽  
Juraj Letko ◽  
Andrea Vecchione ◽  
Andrea Morrione ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Mitochondrial Protein ◽  
Prostate Cancer Cells

Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (9) ◽  
pp. 975-984 ◽  
Author(s):  
Akio Horiguchi ◽  
Rong Zheng ◽  
Ruoqian Shen ◽  
David M. Nanus
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Protein ◽  
Prostate Cancer Cells

scholarly journals Correction: Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells

Oncotarget ◽  
2019 ◽  
Vol 10 (67) ◽  
pp. 7181-7182
Author(s):  
Xinpei Yu ◽  
Junkui Ai ◽  
Liquan Cai ◽  
Yifeng Jing ◽  
Dan Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Prostate Cancer Cells

scholarly journals Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent

The Prostate ◽  
2012 ◽  
Vol 72 (16) ◽  
pp. 1767-1778 ◽  
Author(s):  
Hsiang-Yu Lin ◽  
Yi-Chiu Kuo ◽  
Yu-I Weng ◽  
I-Lu Lai ◽  
Tim H.-M. Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Energy Restriction ◽  
Prostate Cancer Cells ◽  
Suppressor Genes
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