scholarly journals Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity

Oncogene ◽  
2009 ◽  
Vol 28 (37) ◽  
pp. 3332-3344 ◽  
Author(s):  
M Brunet Simioni ◽  
A De Thonel ◽  
A Hammann ◽  
A L Joly ◽  
G Bossis ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Transcription Factor Activity ◽  
Factor Activity

Transcription regulation of alpha B-crystallin in astrocytes: analysis of HSF and AP1 activation by different types of physiological stress

1996 ◽  
Vol 109 (5) ◽  
pp. 1029-1039
Author(s):  
M.W. Head ◽  
L. Hurwitz ◽  
J.E. Goldman
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Physiological Stress ◽  
Heat Shock Protein 27 ◽  
Heat Shock Factor ◽  
Transcriptional Level ◽  
Heat Shock Factor 1 ◽  
Hypertonic Stress ◽  
Transcriptional Activator Protein ◽  
Different Types

The coordinated cellular responses to physiological stress are known to be effected in part by the activation of heat-shock factor 1, a transcriptional activator protein capable of binding to, and inducing transcription from genes containing heat shock elements. Other stress responsive signal transduction pathways also exist including the stress activated protein kinase cascade that regulates the activity of the transcription factor AP1. We have examined the expression of the low molecular stress proteins, heat shock protein 27 and alpha B-crystallin in astrocytes in response to physiological stress of different types and asked what component of this induction is effected at the transcriptional level and whether activation of heat shock factor 1 and AP1 might account for these events. We have found that stress regulated induction of alpha B-crystallin has a strong transcriptional component and that it may be effected by at least two different transcriptional mechanisms. In one set of phenomena, represented here by cadmium exposure, alpha B-crystallin and heat shock protein 27 are coordinately regulated and this occurs in the presence of activated heat shock factor 1. In the second series of phenomena, represented here by hypertonic stress, alpha B-crystallin is induced in the absence of heat shock factor activation and in the absence of any corresponding change in heat shock protein 27 expression. Although hypertonic stress does activate an AP1-like binding activity, the AP1 consensus binding site in the alpha B-crystallin promoter does not appear to be a target for this hypertonic stress inducible activity. These data suggest that the hypertonic stress response is effected through a heat shock factor independent mechanism and that hypertonic stress regulated induction of alpha B-crystallin does not directly depend on the SAPK pathway and AP1 activity.

scholarly journals Increased expression of heat shock protein 70 and heat shock factor 1 in chronic dermal ulcer tissues treated with laser-aided therapy

2008 ◽  
Vol 121 (14) ◽  
pp. 1269-1273 ◽  
Author(s):  
Jian-da ZHOU ◽  
Cheng-qun LUO ◽  
Hui-qing XIE ◽  
Xin-min NIE ◽  
Yan-zhong ZHAO ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1
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