scholarly journals Dietary Patterns, Abdominal Visceral Adipose Tissue, and Cardiometabolic Risk Factors in African Americans: The Jackson Heart Study

Obesity ◽  
2012 ◽  
Author(s):  
Jiankang Liu ◽  
DeMarc A. Hickson ◽  
Solomon K. Musani ◽  
Sameera A. Talegawkar ◽  
Teresa C. Carithers ◽  
...  
Obesity ◽  
2013 ◽  
Vol 21 (3) ◽  
pp. 644-651 ◽  
Author(s):  
Jiankang Liu ◽  
DeMarc A. Hickson ◽  
Solomon K. Musani ◽  
Sameera A. Talegawkar ◽  
Teresa C. Carithers ◽  
...  

2014 ◽  
Vol 10 (3) ◽  
pp. 172-179 ◽  
Author(s):  
T. A. Bosch ◽  
D. R. Dengel ◽  
A. S. Kelly ◽  
A. R. Sinaiko ◽  
A. Moran ◽  
...  

2015 ◽  
Vol 309 (8) ◽  
pp. E736-E746 ◽  
Author(s):  
Marie Michèle Boulet ◽  
Geneviève Chevrier ◽  
Thomas Grenier-Larouche ◽  
Mélissa Pelletier ◽  
Mélanie Nadeau ◽  
...  

Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked to altered adipose tissue BCAA catabolism. We tested the hypothesis that some features of this metabolite signature relate closely to visceral obesity and concomitant alterations in cardiometabolic risk factors. We also postulated that alterations in BCAA-catabolizing enzymes are predominant in visceral adipose tissue. Fifty-nine women (BMI 20–41 kg/m2) undergoing gynecologic surgery were recruited and characterized for overall and regional adiposity, blood metabolite levels using targeted metabolomics, and cardiometabolic risk factors. Adipose samples (visceral and subcutaneous) were obtained and used for gene expression and Western blot analyses. Obese women had significantly higher circulating BCAA and kynurenine/tryptophan (Kyn/Trp) ratio than lean or overweight women ( P < 0.01). Principal component analysis confirmed that factors related to AA and the Kyn/Trp ratio were positively associated with BMI, fat mass, visceral or subcutaneous adipose tissue area, and subcutaneous adipocyte size ( P ≤ 0.05). AA-related factor was positively associated with HOMA-IR ( P ≤ 0.01). Factors reflecting glycerophospholipids and sphingolipids levels were mostly associated with altered blood lipid concentrations ( P ≤ 0.05). Glutamate level was the strongest independent predictor of visceral adipose tissue area ( r = 0.46, P < 0.001). Obese women had lower expression and protein levels of BCAA-catabolizing enzymes in visceral adipose tissue than overweight or lean women ( P ≤ 0.05). We conclude that among metabolites altered in obesity plasma concentrations of BCAA and the Kyn/Trp ratio are closely related to increased adiposity. Alterations in expression and protein levels of BCAA-catabolizing enzymes are predominant in visceral adipose tissue.


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2360-PUB
Author(s):  
ANGÉLICA M.M. VALENTE ◽  
BIANCA ALMEIDA-PITITTO ◽  
ALEXANDRE A. FERRARO ◽  
LUCIANA FOLCHETTI ◽  
ISIS T. SILVA ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Marie W. Lundblad ◽  
Bjarne K. Jacobsen ◽  
Jonas Johansson ◽  
Emanuella De Lucia Rolfe ◽  
Sameline Grimsgaard ◽  
...  

Background. Reference values for visceral adipose tissue (VAT) are needed and it has been advocated that body composition measures depend on both the technique and methods applied, as well as the population of interest. We aimed to develop reference values for VAT in absolute grams (VATg), percent (VAT%), and as a kilogram-per-meters-squared index (VATindex) for women and men, and investigate potential differences between these measures and their associations with cardiometabolic risk factors (including metabolic syndrome (MetS)). Methods. In the seventh survey of the population-based Tromsø Study, 3675 participants (aged 40–84, 59% women) attended whole-body DXA scans (Lunar Prodigy GE) from where VAT was derived. We used descriptive analysis, correlations, receiver operating characteristics (ROC), and logistic regression to propose reference values for VAT and investigated VAT’s association with cardiometabolic risk factors, MetS and single MetS components. Further, Youden’s index was used to suggest threshold values for VAT. Results. VATg and VATindex increased until age 70 and then decreased, while VAT% increased with age across all age groups. VAT (all measurement units) was moderate to highly correlated and significantly associated with all cardiometabolic risk factors, except for total cholesterol. Associations between MetS, single MetS components, and VATg and VATindex were similar, and VAT% did not contribute any further to this association. Conclusion. These VAT reference values and thresholds, developed in a sample of adults of Norwegian origin, could be applied to other studies with similar populations using the same DXA device and protocols. The associations between VAT and cardiometabolic risk factors were similar across different measurement units of VAT.


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