scholarly journals Glucose Tolerance in Response to a High-Fat Diet Is Improved by a High-Protein Diet

Obesity ◽  
2012 ◽  
Vol 20 (9) ◽  
pp. 1859-1865 ◽  
Author(s):  
Mary A. Honors ◽  
Sara L. Hargrave ◽  
Kimberly P. Kinzig
1985 ◽  
Vol 54 (3) ◽  
pp. 567-575 ◽  
Author(s):  
H. C. Mehta ◽  
A. S. Saini ◽  
Harjit Singh ◽  
P. S. Dhatt

1. Sixty marasmic children were investigated for the absorption of xylose, proteins and fats. Their duodenal juice samples were also analysed for bile salts and microflora.2. The marasmic children were then studied in three groups of twenty by allocating them to three different dietary schedules: a high-protein diet (30% of the total energy from protein), a high-fat diet (40% of the total energy from fat) and a high-carbohydrate diet (70% of the total energy from carbohydrate) for 2 weeks and the previous measurements repeated.3. Whereas the high-fat diet resulted in improved fat absorption, along with an increase in total and conjugated bile acids, and the high-carbohydrate diet led to improved xylose absorption, the diet rich in protein resulted in an improvement in the absorption of all three dietary ingredients. It appears that a high-protein diet improves the overall absorption process by improving the intestinal environment as a whole, while high-carbohydrate and high-fat diets bring about adaptive changes related to the respective absorptive processes.


1983 ◽  
Vol 49 (2) ◽  
pp. 187-192
Author(s):  
Salil K. Das ◽  
Munalula L. Elliott ◽  
Halifax C. King

1. The effect of the nature and amount of dietary energy on the lipid composition of rat gingival tissue was studied. Male weanling rats were given one of three iso-energetic diets: high-carbohydrate, high-protein and extremely high-protein, or a fourth high-fat diet, for 49 d.2. The high-carbohydrate, extremely high-protein and high-fat diets caused significant increases in the gingival levels of total lipids compared with the normal-protein diet. These increases in total lipids were due primarily to increases in the levels of triglycerides and cholesterol esters. There were no significant differences in the fatty acid compositions of either non-polar or polar lipids among rats given the high-carbohydrate diet and those given the high-protein diet.3. A comparison of the fatty acid composition of lipids of rats given the extremely high-protein diet and the other two iso-energetic diets revealed that the proportion of palmitic acid was higher and the proportion of oleic acid was lower in animals given the extremely high-protein diet than in animals given the other two diets. Compared with the three iso-energetic low-fat diets, the high-fat diet caused decreases in the proportion of palmitic and palmitoleic acids and increases in the proportion of linoleic, arachidonic and docosapentaenoic acids in total fatty acids of both non-polar and polar lipids. It should be noted that the high-fat diet contained a high proportion of linoleic acid and it is expected that this diet would raise the 18:2 fatty acid content of the lipids and also would raise the 20:4 and 22:5 levels as 18:2 is an essential fatty acid and will, with its metabolites, be directly incorporated into tissue lipids.


2015 ◽  
Vol 148 (4) ◽  
pp. S-541-S-542
Author(s):  
Lixin Wang ◽  
Joseph R. Reeve ◽  
Joseph R. Pisegna ◽  
Yvette Tache

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Camila Lubaczeuski ◽  
Luciana Mateus Gonçalves ◽  
Jean Franciesco Vettorazzi ◽  
Mirian Ayumi Kurauti ◽  
Junia Carolina Santos-Silva ◽  
...  

The aim of this study was to investigate the effect of subdiaphragmatic vagotomy on insulin sensitivity, secretion, and degradation in metabolic programmed mice, induced by a low-protein diet early in life, followed by exposure to a high-fat diet in adulthood. Weaned 30-day-old C57Bl/6 mice were submitted to a low-protein diet (6% protein). After 4 weeks, the mice were distributed into three groups: LP group, which continued receiving a low-protein diet; LP + HF group, which started to receive a high-fat diet; and LP + HFvag group, which underwent vagotomy and also was kept at a high-fat diet. Glucose-stimulated insulin secretion (GSIS) in isolated islets, ipGTT, ipITT, in vivo insulin clearance, and liver expression of the insulin-degrading enzyme (IDE) was accessed. Vagotomy improved glucose tolerance and reduced insulin secretion but did not alter adiposity and insulin sensitivity in the LP + HFvag, compared with the LP + HF group. Improvement in glucose tolerance was accompanied by increased insulinemia, probably due to a diminished insulin clearance, as judged by the lower C-peptide : insulin ratio, during the ipGTT. Finally, vagotomy also reduced liver IDE expression in this group. In conclusion, when submitted to vagotomy, the metabolic programmed mice showed improved glucose tolerance, associated with an increase of plasma insulin concentration as a result of insulin clearance reduction, a phenomenon probably due to diminished liver IDE expression.


2001 ◽  
Vol 233 (5) ◽  
pp. 688-695 ◽  
Author(s):  
Kaspar Z’graggen ◽  
Andrew L. Warshaw ◽  
Jens Werner ◽  
Fiona Graeme-Cook ◽  
Ramon E. Jimenez ◽  
...  

1971 ◽  
Vol 29 (2) ◽  
pp. 95-106
Author(s):  
Akira Arai ◽  
Chikako Ogasawara ◽  
Shinjiro Suzuki

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 586 ◽  
Author(s):  
Mads Hjorth ◽  
George Bray ◽  
Yishai Zohar ◽  
Lorien Urban ◽  
Derek Miketinas ◽  
...  

Efforts to identify a preferable diet for weight management based on macronutrient composition have largely failed, but recent evidence suggests that satiety effects of carbohydrates may depend on the individual’s insulin-mediated cellular glucose uptake. Therefore, using data from the POUNDS LOST trial, pre-treatment fasting plasma glucose (FPG), fasting insulin (FI), and homeostatic model assessment of insulin resistance (HOMA-IR) were studied as prognostic markers of long-term weight loss in four diets differing in carbohydrate, fat, and protein content, while assessing the role of dietary fiber intake. Subjects with FPG <100 mg/dL lost 2.6 (95% CI 0.9;4.4, p = 0.003) kg more on the low-fat/high-protein (n = 132) compared to the low-fat/average-protein diet (n = 136). Subjects with HOMA-IR ≥4 lost 3.6 (95% CI 0.2;7.1, p = 0.038) kg more body weight on the high-fat/high-protein (n = 35) compared to high-fat/average-protein diet (n = 33). Regardless of the randomized diet, subjects with prediabetes and FI below the median lost 5.6 kg (95% CI 0.6;10.6, p = 0.030) more when consuming ≥35 g (n = 15) compared to <35 g dietary fiber/10 MJ (n = 16). Overall, subjects with normal glycemia lost most on the low-fat/high-protein diet, subjects with high HOMA-IR lost most on the high-fat/high protein diet, and subjects with prediabetes and low FI had particular benefit from dietary fiber in the diet.


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