scholarly journals Age-Related Changes in Insulin Sensitivity and β-Cell Function Among European-American and African-American Women

Obesity ◽  
2011 ◽  
Vol 19 (3) ◽  
pp. 528-535 ◽  
Author(s):  
Paula C. Chandler-Laney ◽  
Radhika P. Phadke ◽  
Wesley M. Granger ◽  
José R. Fernández ◽  
Julian A. Muñoz ◽  
...  
Keyword(s):  
African American ◽  
Insulin Sensitivity ◽  
African American Women ◽  
Cell Function ◽  
European American ◽  
Β Cell ◽  
American Women ◽  
Age Related ◽  
Β Cell Function ◽  
Age Related Changes

scholarly journals Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function

2018 ◽  
Author(s):  
Matthew Wortham ◽  
Jacqueline R. Benthuysen ◽  
Martina Wallace ◽  
Jeffrey N. Savas ◽  
Francesca Mulas ◽  
...  
Keyword(s):  
Cell Function ◽  
Coupling Factor ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Age Related ◽  
Β Cell Function ◽  
One Year ◽  
Old Mice ◽  
Age Related Changes

SummaryPancreatic β-cell physiology changes substantially throughout life; yet, the mechanisms that drive these changes are poorly understood. Here, we performed comprehensive in vivo quantitative proteomic profiling of pancreatic islets from adolescent and one-year-old mice. The analysis revealed striking differences in abundance of enzymes controlling glucose metabolism. We show that these changes in protein abundance are associated with higher activities of glucose metabolic enzymes involved in coupling factor generation as well as increased activity of the coupling factor-dependent amplifying pathway of insulin secretion. Nutrient tracing and targeted metabolomics demonstrated accelerated accumulation of glucose-derived metabolites and coupling factors in islets from one-year-old mice, indicating that age-related changes in glucose metabolism contribute to improved glucose-stimulated insulin secretion with age. Together, our study provides the first in-depth characterization of age-related changes in the islet proteome and establishes metabolic rewiring as an important mechanism for age-associated changes in β-cell function.

Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β‐Cell Function

Obesity ◽  
2021 ◽  
Author(s):  
Anny H. Xiang ◽  
Mayra P. Martinez ◽  
Enrique Trigo ◽  
Kristina M. Utzschneider ◽  
Melanie Cree‐Green ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Gastric Banding ◽  
Cell Function ◽  
Liver Fat ◽  
Β Cell ◽  
Fat Reduction ◽  
Β Cell Function

β‐cell function, incretin response, and insulin sensitivity of glucose and fat metabolism in obese youth: Relationship to OGTT‐time‐to‐glucose‐peak

2019 ◽  
Vol 21 (1) ◽  
pp. 18-27
Author(s):  
Joon Young Kim ◽  
Hala Tfayli ◽  
Fida Bacha ◽  
SoJung Lee ◽  
Sara F. Michaliszyn ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Cell Function ◽  
Fat Metabolism ◽  
Β Cell ◽  
Obese Youth ◽  
Β Cell Function

scholarly journals Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY

Diabetes Care ◽  
2016 ◽  
Vol 40 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Silva Arslanian ◽  
Laure El ghormli ◽  
Fida Bacha ◽  
Sonia Caprio ◽  
Robin Goland ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Treatment Failure ◽  
Cell Function ◽  
Ethnic Disparity ◽  
Failure Rates ◽  
Β Cell ◽  
Β Cell Function ◽  
Racial Ethnic
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