scholarly journals Retinol-binding Protein 4 (RBP4) Protein Expression Is Increased in Omental Adipose Tissue of Severely Obese Patients

Obesity ◽  
2010 ◽  
Vol 18 (4) ◽  
pp. 663-666 ◽  
Author(s):  
Karen R. Kelly ◽  
Sangeeta R. Kashyap ◽  
Valerie B. O'Leary ◽  
Jennifer Major ◽  
Philip R. Schauer ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Protein Expression ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Obese Patients ◽  
Retinol Binding Protein 4 ◽  
Omental Adipose Tissue ◽  
Severely Obese

Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases

2008 ◽  
Vol 114 (4) ◽  
pp. 275-288 ◽  
Author(s):  
Herbert Tilg ◽  
Alexander R. Moschen
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Clinical Medicine ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Acid Oxidation ◽  
Endothelial Cell Function ◽  
Retinol Binding Protein 4 ◽  
Associated Diseases ◽  
Anti Inflammatory

Obesity and obesity-related disorders play an important role in clinical medicine. Adipose tissue, with its soluble mediators called adipocytokines, has emerged as a major endocrine organ. These adipocytokines comprise many mediators such as adiponectin, PBEF (pre-B-cell-enhancing factor)/visfatin, leptin, resistin, retinol-binding protein-4 and others. They play major roles in key aspects of metabolism, such as insulin resistance, fatty acid oxidation, inflammation and immunity. Adiponectin, a prototypic adipocytokine, is of importance in the regulation of insulin resistance, as circulating levels are decreased in obesity and diseases associated with insulin resistance. Besides its major role in regulation of insulin sensitivity, recent evidence suggests potent anti-inflammatory functions for adiponectin. These effects are paralleled by other immune-regulatory properties, such as regulation of endothelial cell function. The in vitro effects of adiponectin have been corroborated by several studies demonstrating potent in vivo anti-inflammatory effects. Many other adipocytokines, such as PBEF/visfatin, leptin, resistin or retinol binding protein-4, are involved in the physiology and pathophysiology of adipocytes, adipose tissue and related diseases. PBEF/visfatin, another recently characterized adipocytokine, has been linked to several inflammatory disease states beyond insulin resistance, such as acute lung injury or inflammatory bowel diseases. It has been recognized for many decades that obesity is accompanied by an increase in cancer and potentially some immune-mediated diseases. Understanding this new exciting world of adipocytokines will be of importance in the development of novel therapies for obesity-associated diseases.

scholarly journals Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Zeynep Goktas ◽  
Shannon Owens ◽  
Mallory Boylan ◽  
David Syn ◽  
Chwan-Li Shen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Morbidly Obese ◽  
Tissue Samples ◽  
Blood Concentrations ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Retinol Binding Protein 4 ◽  
Obese Subjects

Visfatin/Nampt, vaspin, and retinol binding protein-4 (RBP-4) play an important role in insulin resistance. The objectives of this study were to measure visfatin/Nampt, vaspin, and RBP-4 concentrations in blood, liver, muscle, subcutaneous, omental, and mesenteric adipose tissues in morbidly obese subjects and investigate their relationship to insulin resistance. Blood and tissue samples were collected from 38 morbidly obese subjects during Roux-en-Y surgery. Insulin resistance biomarkers were measured using standard kits. Visfatin/Nampt, vaspin, and RBP-4 gene expression levels in tissues were measured using real-time PCR. Their protein concentrations in blood and tissues were measured using ELISA kits. Diabetic subjects had significantly higher homeostasis model of assessment-insulin resistance and age and lower blood HDL-cholesterol concentrations than nondiabetic and prediabetic subjects. Diabetic and prediabetic subjects had significantly higher blood concentrations of visfatin/Nampt and vaspin than nondiabetic subjects. Liver RBP-4 concentrations were positively associated with blood glucose concentrations. Blood insulin resistance biomarker levels were positively associated with visfatin/Nampt concentrations in omental adipose tissue and liver, and vaspin concentrations in mesenteric adipose tissue. In conclusion, the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent.

scholarly journals Serum retinol binding protein 4 is not decreased in congenital generalized lipodystrophy: a case series

2011 ◽  
Vol 55 (4) ◽  
pp. 279-283
Author(s):  
Amélio F. Godoy-Matos ◽  
Rodrigo O. Moreira ◽  
Renata MacDowell ◽  
Izidro Bendet
Keyword(s):  
Adipose Tissue ◽  
Binding Protein ◽  
Case Series ◽  
The Other ◽  
Retinol Binding Protein ◽  
Control Group ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Congenital Generalized Lipodystrophy ◽  
Healthy Control

INTRODUCTION: Previous studies have suggested that Retinol Binding Protein 4 (RPB4), a protein produced by the adipose tissue, is associated with insulin resistance (IR). Congenital Generalized Lipodystrophy (CGL) is a rare disease characterized by IR and paucity of adipose tissue. Our objective was to determine RBP4 levels in patients with CGL. SUBJECTS AND METHODS: Six (6) patients with CGL and a healthy control group were selected to participate in the study. Anthropometric and biochemical variables were compared between groups. RESULTS: No difference was observed in RBP4 levels between the two groups (CGL 42.5 [12.5 - 127] vs. control 57.4 [15.9 - 165]; p = 0.78). On the other hand, leptin levels were significantly lower in CGL patients (CGL 0.65 [0.2 - 0.7] vs. control 10.9 [0.9 - 38.6]; p = 0.015). No correlation was found between RBP-4 and waist circunference (r = 0.18, p = 0.57), or BMI (r = 0.24, p = 0.45). CONCLUSION: RBP4 is not decreased in CGL. These results suggest that adipose tissue may not be the main source of RBP4.

Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children

2011 ◽  
Vol 6 (2-2) ◽  
pp. e345-e352 ◽  
Author(s):  
D. Friebe ◽  
M. Neef ◽  
S. Erbs ◽  
K. Dittrich ◽  
J. Kratzsch ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Tissue Mass ◽  
Retinol Binding Protein 4 ◽  
Adipose Tissue Mass
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