scholarly journals Evidence for Three Novel QTLs for Adiposity on Chromosome 2 With Epistatic Interactions: The NHLBI Family Heart Study

Obesity ◽  
2009 ◽  
Vol 17 (12) ◽  
pp. 2190-2195 ◽  
Author(s):  
Mary F. Feitosa ◽  
Kari E. North ◽  
Richard H. Myers ◽  
James S. Pankow ◽  
Ingrid B. Borecki
Keyword(s):  
Chromosome 2 ◽  
Epistatic Interactions ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

scholarly journals Sugar-Sweetened Beverage Consumption and Calcified Atherosclerotic Plaques in the Coronary Arteries: The NHLBI Family Heart Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1775
Author(s):  
Yash R. Patel ◽  
Tasnim F. Imran ◽  
R. Curtis Ellison ◽  
Steven C. Hunt ◽  
John Jeffrey Carr ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Coronary Arteries ◽  
Subclinical Atherosclerosis ◽  
Agatston Score ◽  
Sugar Sweetened Beverage ◽  
Cut Points ◽  
Sweetened Beverage ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

Background: Sugar-sweetened beverage (SSB) intake is associated with higher risk of weight gain, diabetes, hypertension, cardiovascular disease, and cardiovascular mortality. However, the association of SSB with subclinical atherosclerosis in the general population is unknown. Objective: Our primary objective was to investigate the association between SSB intake and prevalence of atherosclerotic plaque in the coronary arteries in The National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Methods: We studied 1991 participants of the NHLBI Family Heart Study without known coronary heart disease. Intake of SSB was assessed through a semi-quantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac Computed Tomography (CT) and prevalent CAC was defined as an Agatston score ≥100. We used generalized estimating equations to calculate adjusted prevalence ratios of CAC. A sensitivity analysis was also performed at different ranges of cut points for CAC. Results: Mean age and body mass index (BMI) were 55.0 years and 29.5 kg/m2, respectively, and 60% were female. In analysis adjusted for age, sex, BMI, smoking, alcohol use, physical activity, energy intake, and field center, higher SSB consumption was not associated with higher prevalence of CAC [prevalence ratio (95% confidence interval) of: 1.0 (reference), 1.36 (0.70–2.63), 1.69 (0.93–3.09), 1.21 (0.69–2.12), 1.05 (0.60–1.84), and 1.58 (0.85–2.94) for SSB consumption of almost never, 1–3/month, 1/week, 2–6/week, 1/day, and ≥2/day, respectively (p for linear trend 0.32)]. In a sensitivity analysis, there was no evidence of association between SSB and prevalent CAC when different CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions: These data do not provide evidence for an association between SSB consumption and prevalent CAC in adult men and women.

scholarly journals A QTL on 12q Influencing an Inflammation Marker and Obesity in White Women: The NHLBI Family Heart Study

Obesity ◽  
2009 ◽  
Vol 17 (3) ◽  
pp. 525-531 ◽  
Author(s):  
Jun Wu ◽  
James S. Pankow ◽  
Russell P. Tracy ◽  
Kari E. North ◽  
Richard H. Myers ◽  
...  
Keyword(s):  
White Women ◽  
Inflammation Marker ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

scholarly journals NHLBI Family Heart Study: Objectives and Design

1996 ◽  
Vol 143 (12) ◽  
pp. 1219-1228 ◽  
Author(s):  
M. Higgins ◽  
M. Province ◽  
G. Heiss ◽  
J. Eckfeldt ◽  
R. C. Ellison ◽  
...  
Keyword(s):  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study

2006 ◽  
Vol 291 (6) ◽  
pp. H2752-H2757 ◽  
Author(s):  
Qingwei Wang ◽  
Steven C. Hunt ◽  
Qin Xu ◽  
Yuqing E. Chen ◽  
Michael A. Province ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Intima Media Thickness ◽  
Epidemiological Studies ◽  
Study Cohort ◽  
Strong Impact ◽  
Snp Analysis ◽  
Nucleotide Polymorphisms ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

Recent epidemiological studies have indicated that baseline C-reactive protein (CRP) levels may have value in prediction of cardiovascular risk. Using six tag single-nucleotide polymorphisms (SNPs) selected from our complete list of SNPs on the CRP gene, we investigated the association of CRP genotypes with plasma CRP levels and cardiovascular risk in the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study cohort (1,296 Caucasians, 48.5% male, 54.7 ± 12.8 yr old). There was a significant trend toward association of CRP haplotypes with CRP levels ( P = 0.045). SNP analysis indicated a highly significant association of SNP −757 (rs3093059, P = 0.0004) and SNP −286 (rs3091244, P = 0.0065) and a borderline association of SNP −7180 (rs1341665, P = 0.06) with CRP levels. Neither CRP haplotypes nor individual SNP genotypes were associated with intima-media thickness of the common carotid or internal carotid artery or the bifurcation of the carotid arteries. These results indicated a strong impact of local SNPs of the CRP gene on plasma CRP levels, but there was no direct evidence that these genetically controlled CRP elevations by local CRP SNPs contributed to cardiovascular disease phenotypes.

Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study

2001 ◽  
Vol 154 (3) ◽  
pp. 681-689 ◽  
Author(s):  
James S Pankow ◽  
Aaron R Folsom ◽  
Mary Cushman ◽  
Ingrid B Borecki ◽  
Paul N Hopkins ◽  
...  
Keyword(s):  
Genetic Determinants ◽  
Markers Of Inflammation ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

Accuracy of proband reported family history: The NHLBI Family Heart Study (FHS)

1999 ◽  
Vol 17 (2) ◽  
pp. 141-150 ◽  
Author(s):  
Jeannette T. Bensen ◽  
Angela D. Liese ◽  
Julia T. Rushing ◽  
Michael Province ◽  
Aaron R. Folsom ◽  
...  
Keyword(s):  
Family History ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from The NHLBI Family Heart Study

1995 ◽  
Vol 116 (1) ◽  
pp. 147-151 ◽  
Author(s):  
Andrew G. Bostom ◽  
Paul F. Jacques ◽  
Marie R. Nadeau ◽  
Roger R. Williams ◽  
R.Curtis Ellison ◽  
...  
Keyword(s):  
Plasma Homocysteine ◽  
Total Plasma ◽  
Family Heart Study ◽  
Methionine Load ◽  
Heart Study ◽  
Initial Results ◽  
Nhlbi Family Heart Study

scholarly journals Insulin and hypertension in the NHLBI family heart study: A sibpair approach to a controversial issue

2000 ◽  
Vol 13 (3) ◽  
pp. 240-250 ◽  
Author(s):  
F. Kronenberg ◽  
S. S. Rich ◽  
P. Sholinsky ◽  
D. K. Arnett ◽  
M. E. Province ◽  
...  
Keyword(s):  
Controversial Issue ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study
Sign in / Sign up

Export Citation Format

Share Document