Dietary Fat and Weight Gain Among Women in the Nurses’ Health Study*

Obesity ◽  
2007 ◽  
Vol 15 (4) ◽  
pp. 967-976 ◽  
Author(s):  
Alison E. Field ◽  
Walter C. Willett ◽  
Lauren Lissner ◽  
Graham A. Colditz
Keyword(s):  
Weight Gain ◽  
Dietary Fat ◽  
Health Study

scholarly journals Body Size, Weight Gain, and Postmenopausal Endometrial Cancer Risk in the Nih-aarp Diet and Health Study

2006 ◽  
Vol 163 (suppl_11) ◽  
pp. S40-S40
Author(s):  
S C Chang ◽  
J V Lacey Jr ◽  
L Brinton ◽  
P Hartge ◽  
K Adams ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Body Size ◽  
Weight Gain ◽  
Cancer Risk ◽  
Health Study ◽  
Endometrial Cancer Risk

scholarly journals Midlife Dietary Intakes of Monounsaturated Acids, n–6 Polyunsaturated Acids, and Plant-Based Fat Are Inversely Associated with Risk of Cognitive Impairment in Older Singapore Chinese Adults

2019 ◽  
Vol 150 (4) ◽  
pp. 901-909 ◽  
Author(s):  
Yi-Wen Jiang ◽  
Li-Ting Sheng ◽  
Xiong-Fei Pan ◽  
Lei Feng ◽  
Jian-Min Yuan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Dietary Fat ◽  
Cohort Analysis ◽  
The Elderly ◽  
Health Study ◽  
Inverse Association ◽  
Fat Intake ◽  
Total Carbohydrate ◽  
Dietary Fat Intake ◽  
Singapore Chinese

ABSTRACT Background Previous studies have shown inconsistent results for the relation between dietary fat intake and cognitive function in the elderly. Furthermore, prospective studies on this topic among the Chinese population are scarce. Objectives We aimed to examine the association between midlife dietary fat intake and risk of cognitive impairment in the elderly. Methods Prospective cohort analysis was conducted among 16,736 participants from the Singapore Chinese Health Study. Dietary information was assessed by a validated FFQ at baseline (1993–1998) when participants aged 45–74 y (mean: 53.5; SD: 6.22). Cognitive impairment was identified using the Singapore modified Mini-Mental State Examination at the third follow-up visit (2014–2016) when participants aged 61–96 y (mean: 73.2; SD: 6.41). Multivariable logistic regression models were used to calculate ORs and 95% CIs. Results Cognitive impairment was presented in 2397 participants. When substituted for total carbohydrate, dietary fat intake was inversely related to cognitive impairment (OR comparing extreme quartiles: 0.80; 95% CI: 0.67, 0.94; P-trend = 0.003). The OR (95% CI) comparing extreme quartiles of specific dietary fats was 1.08 (0.89, 1.31; P-trend = 0.51) for SFAs, 0.80 (0.64, 0.99; P-trend = 0.02) for MUFAs, 0.84 (0.72, 0.99; P-trend = 0.02) for PUFAs, 0.92 (0.77, 1.09; P-trend = 0.49) for n–3 PUFAs, and 0.83 (0.70, 0.98; P-trend = 0.01) for n–6 PUFAs. An inverse association was found for plant-based fat (OR: 0.84; 95% CI: 0.72, 0.98; P-trend = 0.02), but not for animal-based fat (OR: 0.96; 95% CI: 0.81, 1.15; P-trend = 0.76). When substituted for SFAs, the OR (95% CI) was 0.77 (0.61, 0.97; P-trend = 0.02) for MUFAs and 0.82 (0.70, 0.95; P-trend = 0.003) for PUFAs. Conclusions We found that substitution of total carbohydrate or SFAs with MUFAs and PUFAs, particularly n–6 PUFAs, was related to a lower risk of cognitive impairment in elderly Chinese participants. In addition, an inverse association with cognitive impairment was found for plant-based fat.

scholarly journals Fish and marine fatty acids intakes, theFADSgenotypes and long-term weight gain: a prospective cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e022877
Author(s):  
Tao Huang ◽  
Tiange Wang ◽  
Yoriko Heianza ◽  
Janey Wiggs ◽  
Dianjianyi Sun ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Weight Gain ◽  
Prospective Cohort ◽  
Fish Intake ◽  
Health Study ◽  
Genetic Associations ◽  
Long Term Changes ◽  
Long Chain

ObjectiveWe tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).DesignThreeFADSvariants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies.SettingPopulation based study.Participants11 323 women from the Nurses’ Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women’s Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS).Main outcomesLong-term (~10 years) changes in BMI and body weight.ResultsIn the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with theFADSrs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of theFADSrs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of theFADSrs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m2per g, p=3×10−5) than the rs174570 non-T carriers (beta=0.16 kg/m2per g, p=0.08). Similar results were observed for fish intake.ConclusionsOur hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with theFADSvariant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts.

scholarly journals Insulin resistance as a modifier of the relationship between dietary fat intake and weight gain

2004 ◽  
Vol 28 (6) ◽  
pp. 803-812 ◽  
Author(s):  
C L Mosca ◽  
J A Marshall ◽  
G K Grunwald ◽  
M A Cornier ◽  
J Baxter
Keyword(s):  
Insulin Resistance ◽  
Weight Gain ◽  
Dietary Fat ◽  
Fat Intake ◽  
Dietary Fat Intake ◽  
The Relationship

scholarly journals Dietary Fat and Postmenopausal Invasive Breast Cancer in the National Institutes of Health-AARP Diet and Health Study Cohort

2007 ◽  
Vol 99 (6) ◽  
pp. 451-462 ◽  
Author(s):  
A. C. M. Thiebaut ◽  
V. Kipnis ◽  
S.-C. Chang ◽  
A. F. Subar ◽  
F. E. Thompson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Dietary Fat ◽  
National Institutes Of Health ◽  
Health Study ◽  
Study Cohort

Alteration of Dietary Fat Intake to Prevent Weight Gain: Jayhawk Observed Eating Trial

Obesity ◽  
2008 ◽  
Vol 16 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Joseph E. Donnelly ◽  
Debra K. Sullivan ◽  
Bryan K. Smith ◽  
Dennis J. Jacobsen ◽  
Richard A. Washburn ◽  
...  
Keyword(s):  
Weight Gain ◽  
Dietary Fat ◽  
Fat Intake ◽  
Dietary Fat Intake ◽  
Prevent Weight Gain

Dietary fat intake and weight gain in women genetically predisposed for obesity

1995 ◽  
Vol 61 (6) ◽  
pp. 1213-1217 ◽  
Author(s):  
B L Heitmann ◽  
L Lissner ◽  
T I Sørensen ◽  
C Bengtsson
Keyword(s):  
Weight Gain ◽  
Dietary Fat ◽  
Fat Intake ◽  
Dietary Fat Intake
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