scholarly journals Adipocyte-derived Lipoprotein Lipase Induces Macrophage Activation and Monocyte Adhesion: Role of Fatty Acids**

Obesity ◽  
2007 ◽  
Vol 15 (11) ◽  
pp. 2595-2604 ◽  
Author(s):  
Ling Li ◽  
Geneviève Renier
Keyword(s):  
Fatty Acids ◽  
Lipoprotein Lipase ◽  
Macrophage Activation ◽  
Monocyte Adhesion ◽  
Adhesion Role

scholarly journals 37TNF-α mediated monocyte adhesion: role of ephrinA1 as potential link to atherosclerosis

2014 ◽  
Vol 103 (suppl 1) ◽  
pp. S5.3-S5 ◽  
Author(s):  
G Ende ◽  
DM Poitz ◽  
A Augstein ◽  
E Wiedemann ◽  
P Barthel ◽  
...  
Keyword(s):  
Monocyte Adhesion ◽  
Potential Link ◽  
Adhesion Role

scholarly journals Fatty acids regulate the expression of lipoprotein lipase gene and activity in preadipose and adipose cells

1996 ◽  
Vol 314 (2) ◽  
pp. 541-546 ◽  
Author(s):  
Ez-Zoubir AMRI ◽  
Lydia TEBOUL ◽  
Christian VANNIER ◽  
Paul-André GRIMALDI ◽  
Gérard AILHAUD
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Lipoprotein Lipase ◽  
Fine Tuning ◽  
Lipase Gene ◽  
Lpl Gene ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Adipose Cells

During fasting, a reduction in lipoprotein lipase (LPL) activity has been observed in rat fat pad with no change in enzyme mass, whereas LPL mRNA and synthesis are increased, suggesting that insulin and/or fatty acids (FA) regulate LPL activity post-translationaly [Doolittle, Ben-Zeev, Elovson, Martin and Kirchgessner (1990) J. Biol. Chem. 265, 4570–4577]. To examine the role of FA, either preadipose Ob1771 cells or Ob1771 and 3T3-F442A adipose cells were exposed to long-chain FA and to 2-bromopalmitate, a non-metabolized FA. A rapid (2–8 h) and dose-dependent increase (up to 6-fold) in LPL mRNA occurred, primarily due to increased transcription, which is accompanied by a decrease (down to 4-fold) in LPL cellular activity. Under these conditions, secretion of active LPL was nearly abolished. Removal of FA led to full recovery of LPL activity. LPL gene expression in 3T3-C2 fibroblasts was not affected by FA treatment. However fatty acid-activated receptor transfected-3T3-C2 cells, which show FA responsiveness, had increased LPL gene expression upon FA addition. LPL synthesis and cellular content appeared unaffected by FA treatment, whereas secretion of LPL was inhibited. These results indicate that FA regulate the post-translational processing of LPL. It is proposed that the regulation of LPL activity by FA is important with regard to the fine-tuning of FA entry into adipocytes during fasting/feeding periods.

The role of unsaturated fatty acids in endotoxin-induced macrophage activation

Immunobiology ◽  
1993 ◽  
Vol 187 (3-5) ◽  
pp. 283-302 ◽  
Author(s):  
F. Ulrich Schade ◽  
Regina Engel ◽  
Stephan Härtling ◽  
Jutta Holler ◽  
Dorothee Jakobs
Keyword(s):  
Fatty Acids ◽  
Macrophage Activation ◽  
Unsaturated Fatty Acids

Breast milk jaundice; the role of lipoprotein lipase and the free fatty acids

1980 ◽  
Vol 134 (1) ◽  
pp. 35-38 ◽  
Author(s):  
A. Constantopoulos ◽  
J. Messaritakis ◽  
N. Matsaniotis
Keyword(s):  
Fatty Acids ◽  
Breast Milk ◽  
Free Fatty Acids ◽  
Lipoprotein Lipase ◽  
Breast Milk Jaundice
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