scholarly journals Modulation and Lack of Cross-Talk between Signal Transducer and Activator of Transcription 5 and Suppressor of Cytokine Signaling-3 in Insulin and Growth Hormone Signaling in 3T3-L1 Adipocytes*

Obesity ◽  
2006 ◽  
Vol 14 (8) ◽  
pp. 1303-1311 ◽  
Author(s):  
David J. Story ◽  
Jacqueline M. Stephens
Keyword(s):  
Growth Hormone ◽  
Cross Talk ◽  
Cytokine Signaling ◽  
Hormone Signaling ◽  
Signal Transducer ◽  
Suppressor Of Cytokine Signaling

scholarly journals Liver X receptor agonist downregulates growth hormone signaling in the liver

2011 ◽  
Vol 8 (2) ◽  
Author(s):  
Fahad Zadjali ◽  
Ruyman Santana-Farre ◽  
Mercedes Mirecki-Garrido ◽  
Ewa Ellis ◽  
Gunnar Norstedt ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hepatic Steatosis ◽  
Hepatic Metabolism ◽  
Liver X Receptor ◽  
Cytokine Signaling ◽  
Hormone Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Lxr Agonists ◽  
Liver X Receptor Agonist ◽  
Gh Receptors

AbstractLiver X receptor (LXR) agonists have been shown to influence the development of hyperlipidemia and atherosclerosis in mouse models. It has also been demonstrated that some LXR agonists can cause hepatic steatosis in experimental animals. Growth hormone (GH) is known to regulate hepatic metabolism and the absence of hepatic GH receptors (GHR) leads to hepatic steatosis. In this study, we analyzed whether the actions of LXR agonists could involve interference with GH signaling. We showed that LXR agonists impair GH signaling in hepatocytes. LXR agonist treatment attenuated GH induction of suppressor of cytokine signaling 2 (

Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling

10.1038/nn954 ◽  
2002 ◽  
Vol 5 (11) ◽  
pp. 1155-1162 ◽  
Author(s):  
Ann M. Turnley ◽  
Clare H. Faux ◽  
Rodney L. Rietze ◽  
Jason R. Coonan ◽  
Perry F. Bartlett
Keyword(s):  
Growth Hormone ◽  
Neuronal Differentiation ◽  
Cytokine Signaling ◽  
Hormone Signaling ◽  
Suppressor Of Cytokine Signaling

scholarly journals CXCR4-mediated Suppressor of Cytokine Signaling Up-regulation Inactivates Growth Hormone Function

2004 ◽  
Vol 279 (43) ◽  
pp. 44460-44466 ◽  
Author(s):  
Ruth Garzón ◽  
Silvia F. Soriano ◽  
José Miguel Rodríguez-Frade ◽  
Lucio Gómez ◽  
Ana Martín de Ana ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling

scholarly journals Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b)

2002 ◽  
Vol 16 (6) ◽  
pp. 1394-1406 ◽  
Author(s):  
Christopher J. Greenhalgh ◽  
Patrick Bertolino ◽  
Sylvia L. Asa ◽  
Donald Metcalf ◽  
Jason E. Corbin ◽  
...  
Keyword(s):  
Postnatal Growth ◽  
Cytokine Signaling ◽  
Growth Enhancement ◽  
Signal Transducer ◽  
Primary Hepatocytes ◽  
Suppressor Of Cytokine Signaling ◽  
Embryonic Fibroblasts ◽  
Adult Mice ◽  
Igf I ◽  
Deficient Mice

Abstract Mice lacking suppressor of cytokine signaling-2 (SOCS-2) exhibit accelerated postnatal growth resulting in adult mice that are 1.3 to 1.5 times the size of normal mice. In this study we examined the somatotrophic pathway to determine whether the production or actions of GH or IGF-I are altered in these mice. We demonstrated that SOCS-2−/− mice do not have elevated GH levels and suffer no major pituitary dysmorphogenesis, and that SOCS-2-deficient embryonic fibroblasts do not have altered IGF-I signaling. Primary hepatocytes from SOCS-2−/− mice, however, did have moderately prolonged signal transducer and activator of transcription 5 signaling in response to GH stimulation. Furthermore, the deletion of SOCS-2 from mice also lacking signal transducer and activator of transcription 5b had little effect on growth, suggesting that the action of SOCS-2 may be the regulation of the GH signaling pathway.

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