scholarly journals Adipose Gene Expression Response of Lean and Obese Mice to Short-term Dietary Restriction*

Obesity ◽  
2006 ◽  
Vol 14 (6) ◽  
pp. 974-979 ◽  
Author(s):  
Evert M. van Schothorst ◽  
Jaap Keijer ◽  
Jeroen L. A. Pennings ◽  
Antoon Opperhuizen ◽  
Charissa E. van den Brom ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dietary Restriction ◽  
Obese Mice ◽  
Short Term ◽  
Gene Expression Response ◽  
Expression Response

scholarly journals Chromatin Dynamics and Gene Expression Response to Heat Exposure in Field-Conditioned versus Laboratory-Cultured Nematostella vectensis

2021 ◽  
Vol 22 (14) ◽  
pp. 7454
Author(s):  
Eviatar Weizman ◽  
Mieka Rinsky ◽  
Noa Simon-Blecher ◽  
Sarit Lampert-Karako ◽  
Orly Yaron ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acid Metabolism ◽  
Heat Exposure ◽  
Chromatin Accessibility ◽  
Nematostella Vectensis ◽  
Rna Seq ◽  
Short Term ◽  
Gene Expression Response ◽  
Chromatin Dynamics ◽  
Expression Response

Organisms’ survival is associated with the ability to respond to natural or anthropogenic environmental stressors. Frequently, these responses involve changes in gene regulation and expression, consequently altering physiology, development, or behavior. Here, we present modifications in response to heat exposure that mimics extreme summertime field conditions of lab-cultured and field-conditioned Nematostella vectensis. Using ATAC-seq and RNA-seq data, we found that field-conditioned animals had a more concentrated reaction to short-term thermal stress, expressed as enrichment of the DNA repair mechanism pathway. By contrast, lab animals had a more diffuse reaction that involved a larger number of differentially expressed genes and enriched pathways, including amino acid metabolism. Our results demonstrate that pre-conditioning affects the ability to respond efficiently to heat exposure in terms of both chromatin accessibility and gene expression and reinforces the importance of experimentally addressing ecological questions in the field.

Gene expression response of mouse lung, liver and white adipose tissue to β-carotene supplementation, knockout of Bcmo1 and sex

2011 ◽  
Vol 55 (10) ◽  
pp. 1466-1474 ◽  
Author(s):  
Yvonne G. J. van Helden ◽  
Roger W. L. Godschalk ◽  
Johannes von Lintig ◽  
Georg Lietz ◽  
Jean-Francois Landrier ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Mouse Lung ◽  
Gene Expression Response ◽  
Expression Response ◽  
Β Carotene

Gene expression response of the alga Fucus virsoides (Fucales, Ochrophyta) to glyphosate solution exposure

2020 ◽  
Vol 267 ◽  
pp. 115483
Author(s):  
Marco Gerdol ◽  
Andrea Visintin ◽  
Sara Kaleb ◽  
Francesca Spazzali ◽  
Alberto Pallavicini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Response ◽  
Expression Response

scholarly journals VExD: A curated resource for human gene expression following viral infection

2021 ◽  
Author(s):  
Phillip J Dexheimer ◽  
Mario Pujato ◽  
Krishna Roskin ◽  
Matthew T Weirauch
Keyword(s):  
Gene Expression ◽  
Viral Infection ◽  
Human Gene ◽  
Application Programming Interface ◽  
Gene Expression Response ◽  
Human Gene Expression ◽  
Link Type ◽  
Uniform Manner ◽  
Expression Response ◽  
Virus Expression

AbstractMotivationHuman viruses cause significant mortality, morbidity, and economic disruption worldwide. The human gene expression response to viral infection can yield important insights into the detrimental effects to the host. To date, hundreds of studies have performed genome-scale profiling of the effect of viral infection on human gene expression. However, no resource exists that aggregates human expression results across multiple studies, viruses, and tissue types.ResultsWe developed the Virus Expression Database (VExD), a comprehensive curated resource of transcriptomic studies of viral infection in human cells. We have processed all studies within VExD in a uniform manner, allowing users to easily compare human gene expression changes across conditions.Availability and ImplementationVExD is freely accessible at https://vexd.cchmc.org for all modern web browsers. An Application Programming Interface (API) for VExD is also available. The source code is available at https://github.com/pdexheimer/[email protected], [email protected]

scholarly journals Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer

2019 ◽  
Author(s):  
Maritere Urioistegui-Arcos ◽  
Rodrigo Aguayo-Ortiz ◽  
María del Pilar Valencia-Morales ◽  
Erika Melchy-Pérez ◽  
Yvonne Rosenstein ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumour Growth ◽  
Transformed Cells ◽  
Rna Seq ◽  
Gene Expression Response ◽  
New Targets ◽  
Increased Sensitivity ◽  
Promoter Occupancy ◽  
Expression Response ◽  
Stress Gene

AbstractDisruption of the enzymatic activities of the transcription factor TFIIH by Triptolide (TPL) or THZ1 could be used against cancer. Here, we used an oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report that tumour cells exhibited highly increased sensitivity to TPL or THZ1 and that the combination of both had an additive effect. TPL affects the interaction between XPB and P52, causing a reduction in the levels of XPB, P52, and P8, but not other TFIIH subunits. RNA-Seq and RNAPII-ChIP-Seq experiments showed that although the levels of many transcripts were reduced, the levels of a significant number were increased after TPL treatment, with maintained or increased RNAPII promoter occupancy. A significant number of these genes encode for factors that have been related to tumour growth and metastasis. Some of these genes were also overexpressed in response to THZ1, which depletion enhances the toxicity of TPL and are possible new targets against cancer.

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