scholarly journals Retrograde Gastric Electrical Stimulation Reduces Food Intake and Weight in Obese Rats

2005 ◽  
Vol 13 (9) ◽  
pp. 1580-1587 ◽  
Author(s):  
Jieyun Yin ◽  
Jiande D.Z. Chen
Keyword(s):  
Electrical Stimulation ◽  
Food Intake ◽  
Gastric Electrical Stimulation ◽  
Obese Rats

Food Intake and Body Weight Responses to Intermittent vs. Continuous Gastric Electrical Stimulation in Diet-Induced Obese Rats

2012 ◽  
Vol 23 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Shiying Li ◽  
Roland Maude-Griffin ◽  
Yan Sun ◽  
Warren Starkebaum ◽  
Jiande D. Z. Chen
Keyword(s):  
Body Weight ◽  
Electrical Stimulation ◽  
Food Intake ◽  
Gastric Electrical Stimulation ◽  
Obese Rats

T1804 Gastric Electrical Stimulation (GES) Reduces Food Intake After Stimulation Is Stopped in Obese Rats

2009 ◽  
Vol 136 (5) ◽  
pp. A-583
Author(s):  
Jing Zhang ◽  
Yan Sun ◽  
Roland Maude-Griffin ◽  
Warren Starkebaum ◽  
Elizabeth D. Firestone ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Food Intake ◽  
Gastric Electrical Stimulation ◽  
Obese Rats

S2090 Food Intake and Body Weight Effects of Intermittent vs. Continuous Gastric Electrical Stimulation (GES) in Obese Rats

2009 ◽  
Vol 136 (5) ◽  
pp. A-328
Author(s):  
Yan Sun ◽  
Jing Zhang ◽  
Roland Maude-Griffin ◽  
Warren Starkebaum ◽  
Beth Firestone ◽  
...  
Keyword(s):  
Body Weight ◽  
Electrical Stimulation ◽  
Food Intake ◽  
Gastric Electrical Stimulation ◽  
Obese Rats

Gastric Electrical Stimulation Using Endoscopically Placed Mucosal Electrodes Reduces Food Intake in Humans

2006 ◽  
Vol 101 (4) ◽  
pp. 798-803 ◽  
Author(s):  
Jun Liu ◽  
Xiaohua Hou ◽  
Gengqing Song ◽  
Hui Cha ◽  
Bin Yang ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Food Intake ◽  
Gastric Electrical Stimulation

Gastric Electrical Stimulation Optimized to Inhibit Gastric Motility Reduces Food Intake in Dogs

2014 ◽  
Vol 25 (6) ◽  
pp. 1047-1055 ◽  
Author(s):  
Geng-Qing Song ◽  
Hongbing Zhu ◽  
Yong Lei ◽  
Charlene Yuan ◽  
Warren Starkebaum ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Food Intake ◽  
Gastric Motility ◽  
Gastric Electrical Stimulation

Gastric electrical stimulation parameter dependently alters ventral medial hypothalamic activity and feeding in obese rats

2011 ◽  
Vol 301 (5) ◽  
pp. G912-G918 ◽  
Author(s):  
Jing Zhang ◽  
Roland Maude-Griffin ◽  
Hongbing Zhu ◽  
Yan Sun ◽  
Warren Starkebaum ◽  
...  
Keyword(s):  
Body Weight ◽  
Electrical Stimulation ◽  
Food Intake ◽  
Pulse Width ◽  
Neuronal Response ◽  
Gastric Electrical Stimulation ◽  
Gastric Distension ◽  
Weight Changes ◽  
Stimulation Parameter ◽  
Discharge Rates

Gastric electrical stimulation (GES) has been used to treat obesity with unclear mechanisms and limited parameter ranges. This study explores effects of GES parameters on ventral medial hypothalamic (VMH) activity, feeding, and body weight in diet-induced obese (DIO) rats. For experiment 1, discharge rates were recorded in 39 gastric distension-responsive (GD-R) neurons in 12 DIO rats. Basal rates were compared with rates under GES using varied pulse amplitudes, widths, frequencies, and train-on times. For experiment 2, a crossover experiment in 16 DIO rats measured food intake and weight effects of GES pulse width, the parameter with the steepest neuronal response gradient in experiment 1. Treatments were sham and 0.5-, 2.0-, and 5.0-ms pulse GES. In experiment 1, 11 of 13 GES parameter sets tested produced significantly ( P < 0.05) altered discharge rates of GD-R neurons. Increases in pulse amplitude ( P < 0.05) and width ( P < 0.0001) produced significant upward linear trends in response over the range tested, with the trend being strongest for pulse width. In experiment 2, over 4 days of 0.5-, 2.0-, and 5.0-ms GES treatment, food intake was 9.6% ( P < 0.05), 21.0% ( P < 0.0001), and 47.3% ( P < 0.0001) lower than under sham-GES, whereas body weight changes were 0.7 ( P = 0.48), 2.2 ( P < 0.05), and 3.5 ( P < 0.002) percentage points lower, respectively. We concluded that GES pulse width increases had the largest effect on VMH neuronal activity, and these effects were paralleled by pulse width-dependent reductions in food intake and body weight. Lengthening pulse width beyond the range used in prior clinical studies may be critical to making GES a viable obesity treatment.

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