scholarly journals Soluble Leptin Receptor and Soluble Receptor-Bound Fraction of Leptin in the Metabolic Syndrome

2003 ◽  
Vol 11 (6) ◽  
pp. 760-768 ◽  
Author(s):  
Anton Sandhofer ◽  
Markus Laimer ◽  
Christoph F. Ebenbichler ◽  
Susanne Kaser ◽  
Bernhard Paulweber ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Leptin Receptor ◽  
Soluble Receptor ◽  
The Metabolic Syndrome ◽  
Soluble Leptin Receptor

scholarly journals Leptin, soluble leptin receptor, and free leptin index in patients with metabolic syndrome

2017 ◽  
Vol 14 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Elena N. Smirnova ◽  
Sofia G. Shulkina
Keyword(s):  
Metabolic Syndrome ◽  
Leptin Receptor ◽  
Therapy Group ◽  
Objective Evaluation ◽  
Leptin Resistance ◽  
Obesity And Overweight ◽  
Soluble Leptin Receptor ◽  
Average Body Mass ◽  
Group 2 ◽  
Healthy Persons

Aim. To assess the levels of leptin, its soluble receptor, and index of the formation of free leptin in metabolic syndrome (MS). Materials and methods. The study included 110 individuals with obesity and overweight. The group 1 consisted of 70 patients with MS (IDF, 2005), the average body mass index (BMI) 38.4 4.4 kg/m2, aged 48.2 2.4 years, with arterial hypertension (AH) 12 degree, without regular antihypertensive therapy. Group 2 "healthy" obesity accounted for 40 patients aged 38.4 6.2 years, BMI 36.0 5.5 kg/m2 without hypertension and metabolic disorders. Group 3 consisted of 30 healthy persons, BMI 27.1 1.3 kg/m2. All patients were evaluated for insulin, HOMA index, leptin, leptin receptor, leptin free index (calculated as the ratio of leptin (ng/ml) to the leptin receptor (ng/ml), multiplied by 100). Results: In patients with MS as compared to other two groups there were higher levels of HOMA IR index, leptin and free leptin index. Values of leptin receptor in groups 1 and 2 did not differ significantly and were lower than in healthy persons. The free leptin index was significantly higher in MS group relative to the group 2 and 15 times higher than in the healthy individuals. Free leptin index correlated with values of BMI (R = 0.32; p = 0.02), blood pressure (R = 0.3; p = 0.04), uric acid (R = 0.27; p = 0.04), triglycerides (R = 0.42; p = 0.02), index HOMA-IR (R = 0.45; p = 0.02). Conclusions: Reduction of soluble leptin receptor, depending on the degree of abdominal obesity, may cause progression of leptin resistance in patients with MS. The levels of leptin and soluble leptin receptor appears to have dramatical gender differences. Calculation of free leptin index should be used for the objective evaluation of leptin resistance, regardless of gender, degree of obesity, and other metabolic parameters.

Influence of the metabolic syndrome on leptin and leptin receptor in breast cancer

2011 ◽  
Vol 50 (8) ◽  
pp. 643-651 ◽  
Author(s):  
Paul A. Carroll ◽  
Laura Healy ◽  
Joanne Lysaght ◽  
Terry Boyle ◽  
John V. Reynolds ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Leptin Receptor ◽  
The Metabolic Syndrome

Weight Loss Increases Soluble Leptin Receptor Levels and the Soluble Receptor Bound Fraction of Leptin

2002 ◽  
Vol 10 (7) ◽  
pp. 597-601 ◽  
Author(s):  
Markus Laimer ◽  
Christoph F. Ebenbichler ◽  
Susanne Kaser ◽  
Anton Sandhofer ◽  
Helmut Weiss ◽  
...  
Keyword(s):  
Weight Loss ◽  
Leptin Receptor ◽  
Soluble Receptor ◽  
Soluble Leptin Receptor

scholarly journals The metabolic syndrome — a neuroendocrine disorder?

2000 ◽  
Vol 83 (S1) ◽  
pp. S49-S57 ◽  
Author(s):  
Per Björntorp ◽  
Roland Rosmond
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Hpa Axis ◽  
Leptin Receptor ◽  
Psychiatric Disease ◽  
Cortisol Secretion ◽  
The Metabolic Syndrome ◽  
Sympathetic Nervous

Central obesity is a powerful predictor for disease. By utilizing salivary cortisol measurements throughout the day, it has now been possible to show on a population basis that perceived stress-related cortisol secretion frequently is elevated in this condition. This is followed by insulin resistance, central accumulation of body fat, dyslipidaemia and hypertension (the metabolic syndrome). Socio-economic and psychosocial handicaps are probably central inducers of hyperactivity of the hypothalamic–pituitary adrenal (HPA) axis. Alcohol, smoking and traits of psychiatric disease are also involved. In a minor part of the population a dysregulated, depressed function of the HPA axis is present, associated with low secretion of sex steroid and growth hormones, and increased activity of the sympathetic nervous system. This condition is followed by consistent abnormalities indicating the metabolic syndrome. Such ‘burned-out’ function of the HPA axis has previously been seen in subjects exposed to environmental stress of long duration. The feedback control of the HPA axis by central glucocorticoid receptors (GR) seems inefficient, associated with a polymorphism in the 5′ end of the GR gene locus. Homozygotes constitute about 14 % of Swedish men (women to be examined). Such men have a poorly controlled cortisol secretion, abdominal obesity, insulin resistance and hypertension. Furthermore, polymorphisms have been identified in the regulatory domain of the GR gene that are associated with elevated cortisol secretion; polymorphisms in dopamine and leptin receptor genes are associated with sympathetic nervous system activity, with elevated and low blood pressure, respectively. These results suggest a complex neuroendocrine background to the metabolic syndrome, where the kinetics of the regulation of the HPA axis play a central role.

1237: Erectile Dysfunction (ED) Evaluation Through the Metabolic Syndrome Window

2005 ◽  
Vol 173 (4S) ◽  
pp. 335-336 ◽  
Author(s):  
Omer Demir ◽  
Tevfik Demir ◽  
Aykut Kefi ◽  
Abdurrahman Comlekci ◽  
Sena Yesil ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Erectile Dysfunction ◽  
The Metabolic Syndrome
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