scholarly journals Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats

2002 ◽  
Vol 10 (9) ◽  
pp. 956-963 ◽  
Author(s):  
Lorraine Ghibaudi ◽  
John Cook ◽  
Constance Farley ◽  
Margaret van Heek ◽  
Joyce J. Hwa
Keyword(s):  
Energy Metabolism ◽  
Fat Intake ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Behavioral and endocrine traits of obesity-prone and obesity-resistant rats on macronutrient diets

1998 ◽  
Vol 274 (6) ◽  
pp. E1057-E1066 ◽  
Author(s):  
Jian Wang ◽  
Jesline T. Alexander ◽  
Ping Zheng ◽  
Hi Joon Yu ◽  
Jordan Dourmashkin ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Fat ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Normal Weight ◽  
Fat Intake ◽  
Sprague Dawley ◽  
Glucose Levels ◽  
Sprague Dawley Rats

Patterns of eating behavior, body weight gain, and hormone changes were examined in normal-weight albino Sprague-Dawley rats on macronutrient diets. These diets consisted of either three separate jars with pure macronutrients, fat, carbohydrate and protein, from which to choose, or a single diet with different concentrations of fat and carbohydrate. Similar patterns on the choice-diet and single-diet paradigms were observed. During the first 7–10 days on these diets but not subsequently, the rats consuming a fat-rich diet exhibit significant hyperphagia, an increase in both total and fat intake that produces higher body weight gain. Compared with a 10% fat diet, a 30% fat diet is associated with a decline in insulin and corticosterone (CORT) levels, whereas a 60% fat diet produces an increase in circulating glucose. Levels of glucose are positively correlated with fat intake, and together these measures are consistently related to body fat. These relationships are most strongly expressed in rats that consume a fat-rich diet with >30% fat. Whereas insulin levels are also positively related to body fat, CORT is inversely related in these normal-weight subjects. In animals consuming a high-fat diet, a clear separation can be seen between “obesity-prone” (OP) rats with 100% greater body fat than “obesity-resistant” (OR) rats. The OP rats, which consume 15% more total calories, have significantly higher insulin and glucose levels. In animals that consume a diet with >30% fat, it is the OP but not the OR rats that exhibit a positive relation between fat intake, glucose levels, and body fat and reveal an additional association between carbohydrate intake, insulin, and body fat. Thus these rats on macronutrient diets exhibit distinct traits that relate behavior to hormone disturbances and adiposity and distinguish subjects that are prone vs. resistant to obesity.

scholarly journals Using dates (Phoenix dactylifera l.) to improve energy metabolism in fatigue-induced Sprague Dawley rats

Future Foods ◽  
2021 ◽  
pp. 100077
Author(s):  
Hana Kadum ◽  
Azizah Hamid ◽  
Faridah Abas ◽  
Nurul Shazini Ramli ◽  
Ahmad Haniff Jaafar ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Phoenix Dactylifera ◽  
Sprague Dawley ◽  
Phoenix Dactylifera L ◽  
Sprague Dawley Rats

scholarly journals Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Duan-Yong Liu ◽  
Chun-Shui Pan ◽  
Yu-Ying Liu ◽  
Xiao-Hong Wei ◽  
Chang-Man Zhou ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Inflammatory Responses ◽  
Mucosal Injury ◽  
Underlying Mechanism ◽  
Trinitrobenzene Sulfonic Acid ◽  
Sprague Dawley ◽  
Colonic Injury ◽  
Sprague Dawley Rats ◽  
Microcirculatory Disturbances

Huang Qi Jian Zhong Pellet (HQJZ) is a famous Chinese medicine formula for treatment of various gastrointestinal tract diseases. This study investigated the role of HQJZ in 2,4,6-trinitrobenzene sulfonic acid- (TNBS-) induced colitis and its underlying mechanism. Colonic mucosal injury was induced by TNBS in the Sprague-Dawley rats. In the HQJZ treatment group, HQJZ was administered (2 g/kg) for 14 days starting from day 1 after TNBS infusion. Colonic mucosal injury occurred obviously 1 day after TNBS challenge and did not recover distinctively until day 15, including an increase in macro- and microscopic scores, a colonic weight index, a decrease in colonic length, a number of functional capillaries, and blood flow. Inverted intravital microscopy and ELISA showed colonic microcirculatory disturbances and inflammatory responses after TNBS stimulation, respectively. TNBS decreased occludin, RhoA, and ROCK-I, while increasing Rac-1, PAK-1, and phosphorylated myosin light chain. In addition, ATP content and ATP5D expression in colonic mucosa decreased after TNBS challenge. Impressively, treatment with HQJZ significantly attenuated all of the alterations evoked by TNBS, promoting the recovery of colonic injury. The present study demonstrated HQJZ as a multitargeting management for colonic mucosal injury, which set in motion mechanisms involving improvement of energy metabolism.

Preferential Fat Intake Increases Adiposity but not Body Weight in Sprague-Dawley Rats

Appetite ◽  
1998 ◽  
Vol 31 (2) ◽  
pp. 127-139 ◽  
Author(s):  
BRENDA K. SMITH ◽  
LISA A. KELLY ◽  
RICARDO PIÑA ◽  
DAVID A. YORK ◽  
GEORGE A. BRAY
Keyword(s):  
Body Weight ◽  
Fat Intake ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Exercise decreases fat selection in female rats during weight cycling

1991 ◽  
Vol 260 (3) ◽  
pp. R518-R524 ◽  
Author(s):  
T. Gerardo-Gettens ◽  
G. D. Miller ◽  
B. A. Horwitz ◽  
R. B. McDonald ◽  
K. D. Brownell ◽  
...  
Keyword(s):  
Dietary Fat ◽  
Food Restriction ◽  
Resting Metabolic Rate ◽  
Female Rats ◽  
Fat Intake ◽  
Weight Cycling ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Ad Libitum ◽  
Caloric Consumption

Weight cycling (weight loss and regain) increases fat intake in rats allowed to self-select a diet from protein, carbohydrate, and fat sources. This study reports the effects of exercise on macronutrient self-selection. Female Sprague-Dawley rats (5 mo old) self-selected their diet. After 3 wk, rats were assigned to one of the following three groups: ad libitum fed sedentary (Con), sedentary food restricted to 40% Con intake (R-Sed), or treadmill exercised (20 m/min, 1 h/day, 6 day/wk) food restricted to 40% Con intake (R-Ex). Food restriction was for 3 wk followed by 5 wk of refeeding. This was repeated for a second cycle. During restriction, body weight decreased by 30% in R-Sed and by 33% in R-Ex than in R-Sed, fat regain was greater in R-Sed. By week 3 of refeeding, total caloric consumption did not differ. However, fat selection increased in R-Sed (56% kcal) vs. R-Ex (30%) and Con (35%). Fat selection in R-Sed increased further during cycle 2 (73% kcal). Resting oxygen consumption decreased during food restriction in R-Sed and R-Ex. After refeeding, resting metabolic rate in R-Ex was significantly greater than in R-Sed. In conclusion, weight cycling increases dietary fat selection and adiposity. Exercise mitigates this effect.

The effect of intake of lamb meat on energy metabolism of Sprague-Dawley rats: possible role of carnitine

2014 ◽  
Vol 54 (7) ◽  
pp. 886
Author(s):  
Xian-Chao Feng ◽  
Lin Chen ◽  
Su Zhuang ◽  
Xing-Lian Xu ◽  
Guang-Hong Zhou
Keyword(s):  
Energy Metabolism ◽  
Control Diet ◽  
Creatine Phosphate ◽  
Control Group ◽  
Sprague Dawley ◽  
Lamb Meat ◽  
Sprague Dawley Rats ◽  
Consumption Rates ◽  
Diet Control ◽  
Cpt I

The purpose of the present study was to determine whether carnitine was responsible for the increased energy metabolism observed in Sprague-Dawley rats following inclusion of lamb meat in their diet. This was tested by feeding one of the following three diets: a control diet (control) based on a standard formulation (AIN-93G), a carnitine-supplemented control diet (CD) and a lamb meat diet (LD). All diets were isocaloric (15.46 kJ/g DM) and contained 18.3% protein, 7.1% fat and 58.3% carbohydrate. The carnitine concentrations in the control diet, CD and LD were 29, 984 and 953 mg/kg, respectively. The expression of carnitine palmitoyltransferase-I(CPT-I)α and CTP-Iβ genes, Na,K-ATPase activities and the contents of fat, ATP and creatine phosphate (Cr.P) in liver and skeletal muscle tissues were measured on Days 7 and 14. Bodyweights, bodyweight gains and oxygen consumption rates (OCR) of rats were also measured. The rats fed the LD had higher OCR, ATP and Cr.P concentrations, expressions of CPT-I gene, Na,K-ATPase activities, and lower fat contents, bodyweights and bodyweight gains (P < 0.05) than did the control-group rats. However, rats fed the CD were not significantly different from those fed the control diet, except for the higher CPT-Iα expression, ATP concentrations and lower fat contents in liver (P < 0.05). We conclude that carnitine intake from lamb was not the main factor accounting for the significant effects of lamb consumption on energy metabolism. However, it is likely that carnitine intake by consumption of lamb meat in the LD partly contributed to lowering fat contents in liver, compared with the CD and the control diet groups.

Effect of duck meat consumption on thyroid hormone concentrations and energy metabolism of Sprague–Dawley rats

Appetite ◽  
2013 ◽  
Vol 69 ◽  
pp. 94-101 ◽  
Author(s):  
Xianchao Feng ◽  
Lin Chen ◽  
Su Zhuang ◽  
Chunbao Li ◽  
Zhenguo Yan ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Thyroid Hormone ◽  
Meat Consumption ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Ergogenic property of Morinda citrifolia L. leaf extract affects energy metabolism in obese Sprague Dawley rats

2021 ◽  
Author(s):  
Syafiq Zikri Salleh ◽  
Azizah Abdul Hamid ◽  
Ahmad Haniff Jaafar ◽  
Nor Diana Abdul Majid ◽  
Nazamid Saari ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Leaf Extract ◽  
Morinda Citrifolia ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

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