scholarly journals Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients

2014 ◽  
Vol 4 (9) ◽  
pp. e133-e133 ◽  
Author(s):  
H Nakamura ◽  
H Jinzu ◽  
K Nagao ◽  
Y Noguchi ◽  
N Shimba ◽  
...  
Keyword(s):  
Amino Acid ◽  
Plasma Amino Acid ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Amino Acid Profiles ◽  
Type 2 Diabetic

scholarly journals Body Mass Index, Fasting Plasma Glucose Levels, and C-peptide Levels as Predictors of the Future Insulin Use in Japanese Type 2 Diabetic Patients

2010 ◽  
Vol 57 (3) ◽  
pp. 237-244 ◽  
Author(s):  
Atsushi GOTO ◽  
Maki TAKAICHI ◽  
Miyako KISHIMOTO ◽  
Yoshihiko TAKAHASHI ◽  
Hiroshi KAJIO ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Glucose Levels ◽  
Insulin Use ◽  
Type 2 Diabetic

scholarly journals Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetic Patients

2011 ◽  
Vol 35 (1) ◽  
pp. 41 ◽  
Author(s):  
Sung-Tae Kim ◽  
Byung-Joon Kim ◽  
Dong-Mee Lim ◽  
In-Geol Song ◽  
Jang-Han Jung ◽  
...  
Keyword(s):  
Subclinical Atherosclerosis ◽  
Surrogate Marker ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Peptide Level ◽  
Type 2 Diabetic

SEVERITY OF LIVER ECHOGENICITY IS CORRELATED TO SERUM C-PEPTIDE LEVELS IN TYPE 2 DIABETIC PATIENTS

2006 ◽  
Vol 61 (1) ◽  
pp. 5-9
Author(s):  
N. Papanas ◽  
G. Symeonidis ◽  
G. Mavridis ◽  
D. Papazoglou ◽  
I. Giannakis ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Type 2 Diabetic

scholarly journals Decrement of postprandial insulin secretion determines the progressive nature of type-2 diabetes

2006 ◽  
Vol 155 (4) ◽  
pp. 615-622 ◽  
Author(s):  
Wan Sub Shim ◽  
Soo Kyung Kim ◽  
Hae Jin Kim ◽  
Eun Seok Kang ◽  
Chul Woo Ahn ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Diabetic Patients ◽  
Β Cell ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Duration Of Diabetes ◽  
Type 2 Diabetic ◽  
Postprandial Insulin

Objective: Type-2 diabetes is a progressive disease. However, little is known about whether decreased fasting or postprandial pancreatic β-cell responsiveness is more prominent with increased duration of diabetes. The aim of this study was to evaluate the relationship between insulin secretion both during fasting and 2 h postprandial, and the duration of diabetes in type-2 diabetic patients. Design: Cross-sectional clinical investigation. Methods: We conducted a meal tolerance test in 1466 type-2 diabetic patients and calculated fasting (M0) and postprandial (M1) β-cell responsiveness. Results: The fasting C-peptide, postprandial C-peptide, M0, and M1 values were lower, but HbA1c values were higher, in patients with diabetes duration > 10 years than those in other groups. There was no difference in the HbA1c levels according to the tertiles of their fasting C-peptide level. However, in a group of patients with highest postprandial C-peptide tertile, the HbA1c values were significantly lower than those in other groups. After adjustment of age, sex, and body mass index (BMI), the duration of diabetes was found to be negatively correlated with fasting C-peptide (γ = −0.102), postprandial C-peptide (γ = −0.356), M0 (γ = −0.263), and M1 (γ = −0.315; P < 0.01 respectively). After adjustment of age, sex, and BMI, HbA1c was found to be negatively correlated with postprandial C-peptide (γ = −0.264), M0 (γ = −0.379), and M1 (γ = −0.522), however, positively correlated with fasting C-peptide (γ = 0.105; P < 0.01 respectively). In stepwise multiple regression analysis, M0, M1, and homeostasis model assessment for insulin resistance (HOMA-IR) emerged as predictors of HbAlc after adjustment for age, sex, and BMI (R2 = 0.272, 0.080, and 0.056 respectively). Conclusions: With increasing duration of diabetes, the decrease of postprandial insulin secretion is becoming more prominent, and postprandial β-cell responsiveness may be a more important determinant for glycemic control than fasting β-cell responsiveness.

Physical training may enhance β-cell function in type 2 diabetes

2004 ◽  
Vol 287 (5) ◽  
pp. E1024-E1031 ◽  
Author(s):  
Flemming Dela ◽  
Michael E. von Linstow ◽  
Kári Joensen Mikines ◽  
Henrik Galbo
Keyword(s):  
Insulin Sensitivity ◽  
Cell Function ◽  
Diabetic Patients ◽  
Β Cell ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Glucagon Test ◽  
Β Cell Function ◽  
Type 2 Diabetic

In healthy young subjects, training increases insulin sensitivity but decreases the capacity to secrete insulin. We studied whether training changes β-cell function in type 2 diabetic patients. Patients, stratified into “moderate” and “low” secretors according to individual C-peptide responses to an intravenous glucagon test, were randomly assigned to a training program [ergometer cycling 30–40 min/day, including at least 20 min at 75% maximum oxygen consumption (V̇o2 max), 5 days/wk for 3 mo] or a sedentary schedule. Before and after the intervention (16 h after last training bout), a sequential hyperglycemic (90 min at 11, 18, and 25 mM) clamp was performed. An intravenous bolus of 5 g of arginine was given at the end. Training increased V̇o2 max 17 ± 13% and decreased heart rate during submaximal exercise ( P < 0.05). During the 3 mo of sedentary lifestyle, insulin and C-peptide responses to the clamp procedures were unchanged in both moderate and low secretors. Likewise, no change in β-cell response was seen after training in the low secretors ( n = 5). In contrast, moderate secretors ( n = 9) showed significant increases in β-cell responses to 18 and 25 mM hyperglycemia and to arginine stimulation. Glucagon responses to arginine as well as measures of insulin sensitivity and Hb A1c levels were not altered by training. In conclusion, in type 2 diabetic patients, training may enhance β-cell function if the remaining secretory capacity is moderate but not if it is low. The improved β-cell function does not require changes in insulin sensitivity and Hb A1c concentration.

T01-P-003 The influence of C-peptide on the early-stage blood pressure control in type 2 diabetic patients

2005 ◽  
Vol 6 (1) ◽  
pp. 133
Author(s):  
E. Fernandez ◽  
O. Sanchez ◽  
E. Sanchez-Largo ◽  
D. Coca ◽  
B. Monge ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Early Stage ◽  
Pressure Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Type 2 Diabetic

scholarly journals Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients

2014 ◽  
Vol 170 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Guoyu Tong ◽  
Xiaomin Hua ◽  
Yingjie Zhong ◽  
Kui Zhang ◽  
Guangyu Gu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Therapy ◽  
Sex Hormone Binding Globulin ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Hormone Binding ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Type 2 Diabetic

ObjectiveMany studies have shown that low sex hormone-binding globulin (SHBG) is associated with insulin resistance, but only few studies have examined how serum SHBG is regulated by insulin in humans. This interventional study aimed to investigate the effect of insulin therapy (IT) on serum SHBG levels in newly diagnosed type 2 diabetic patients.MethodsA total of 80 newly diagnosed type 2 diabetic subjects were enrolled and randomly grouped into a 2-week intensive IT with/without metformin. Serum SHBG, total testosterone, glucose, liver enzymes, lipids, insulin, and C-peptide levels were measured before and after IT.ResultsBefore IT, serum SHBG levels were negatively correlated with BMI, waist circumference (WC), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GT), triglyceride (TG), fasting insulin, and C-peptide, and homeostatic model assessment of insulin resistance (HOMA-IR), and positively with HDL-C (all P for trend <0.05), after adjustment for age and sex. IT increased serum SHBG levels from 26.5±14.5 to 33.2±15.0 nmol/l (P<0.001), increased by 25.2% (95% CI, 20.3 to 30.9%, P<0.001). In a multiple linear regression model adjusting for age, sex, BMI, and WC, the decreases in ΔALT (standardized regression coefficient β=−0.374, P=0.012) and ΔTG (β=−0.380, P=0.020) were independent contributors to the increase in ΔSHBG.ConclusionsIT increases serum SHBG likely through improving insulin resistance and liver function.

scholarly journals L-Cysteine Influx in Type 2 Diabetic Erythrocytes

2010 ◽  
Vol 56 (5) ◽  
pp. 545-551
Author(s):  
S.I. Rizvi ◽  
N. Srivastava
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Amino Acid ◽  
Antioxidant Defense ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Limiting Amino Acid ◽  
Type 2 Diabetic

Erythrocyte oxidative stress has been implicated in the pathogenesis of diabetes mellitus, and the deficiency of antioxidant defense by the glutathione (GSH) pathway is thought to be one of the factors responsible for development of complications in diabetes. Erythrocytes require L-cysteine for the synthesis of GSH and the rate of synthesis is determined only by L-cysteine availability. In the present study we have found that the L-cysteine influx in erythrocytes from type 2 diabetic patients was significantly lower compared to age-matched controls. The decreased influx may be one of the factors leading to low GSH concentration observed in type 2 diabetes. Since L-cysteine is the limiting amino acid in GSH synthesis, any strategy aimed to increase L-cysteine influx in erythrocytes may be beneficial for type 2 diabetic patients.

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