A critical step in the folding of influenza virus HA determined with a novel folding assay

2005 ◽  
Vol 12 (3) ◽  
pp. 258-263 ◽  
Author(s):  
M Claudia Maggioni ◽  
I Marije Liscaljet ◽  
Ineke Braakman
Keyword(s):  
Influenza Virus ◽  
Critical Step

scholarly journals Comparison of the infectivity of influenza Viruses in two host Systems: the Allantois of infect Eggs and Surviving Allantois-on-Shell

1958 ◽  
Vol 56 (4) ◽  
pp. 535-546 ◽  
Author(s):  
S. Fazekas de St Groth ◽  
D. O. White
Keyword(s):  
Influenza Virus ◽  
Virus Particle ◽  
Host Resistance ◽  
Thermal Inactivation ◽  
Allantoic Fluid ◽  
Relative Sensitivity ◽  
Influenza Viruses ◽  
Critical Step ◽  
Test Systems ◽  
Intracellular Stage

It is shown that the assay for infectivity in bits of allantois-on-shell, which has been standardized on the BEL strain, is optimal also for nine representative strains of influenza virus tested.On the average, the sensitivity of the technique is the same as of orthodox allantoic infectivity tests; its precision is always higher. The relative sensitivity of the two tests varies from strain to strain, the log tray/egg differences being SW (+0.88), MEL (+0.51), CAM (+0.31), PR8 (0.28), WSE (+0.25), HUT (−0.02), BEL (−0.22), FMI (−0.35), LEE (−0.47), BON (−1.02). This gradient is the same for fully infective and incomplete forms of influenza virus.The tray/egg gradient of susceptibility is negatively correlated with the variation in host resistance.The differences in susceptibility are not due to any effect of the plastic trays, to thermal inactivation of the virus, to differences in adsorption or viropexis in the two test systems or to the effect of allantoic fluid on the virus particle. The critical step has been shown to occur during the intracellular stage of multiplication.

Influenza virus-induced expression of CCL5 in monocyte/T-cell co-cultures is reduced in COPD

2019 ◽  
Author(s):  
L Betke ◽  
S Yanik ◽  
K Jamal Jameel ◽  
E Bülthoff ◽  
P Bürger ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
Induced Expression

Protein expression changes in cells inoculated with Equine Influenza Virus: antibody microarray analysis

2013 ◽  
Vol 16 (4) ◽  
pp. 663-669
Author(s):  
W. Rozek ◽  
M. Kwasnik ◽  
J.F. Zmudzinski
Keyword(s):  
Influenza Virus ◽  
Protein Quality ◽  
Biological Properties ◽  
Regulation Of Transcription ◽  
Equine Influenza Virus ◽  
Virus Antibody ◽  
Antibody Microarray ◽  
Equine Influenza ◽  
Microarray Technique ◽  
In Cells

AbstractChanges in the level of cellular proteins in cells inoculated with equine influenza virus H7N7 and H3N8 were studied with microarray technique. H3N8 induced pro-apoptotic proteins while H7N7 induced both pro- as well as anti-apoptotic factors. The higher level of some cytoskeleton components and proteins involved in the protein quality control was recorded. Relatively high number of proteins involved in the regulation of transcription was down-regulated. The pattern of changes observed for H7N7 and H3N8 may reflect differences in the biological properties of both serotypes.

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