Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA

2006 ◽  
Vol 13 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Heather C Losey ◽  
Alexander J Ruthenburg ◽  
Gregory L Verdine
Keyword(s):  
Crystal Structure ◽  
Staphylococcus Aureus ◽  
Adenosine Deaminase

scholarly journals Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus

2018 ◽  
Vol 74 (10) ◽  
pp. 632-637
Author(s):  
Lisha Ha ◽  
Jennifer Colquhoun ◽  
Nicholas Noinaj ◽  
Chittaranjan Das ◽  
Paul M. Dunman ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Staphylococcus Aureus ◽  
Rna Processing ◽  
Bacterial Species ◽  
Rna Degradation ◽  
Ribonuclease P ◽  
Protein Subunit ◽  
Aromatic Residues ◽  
Cellular Processes ◽  
P Protein

Staphylococcus aureus ribonuclease-P-protein subunit (RnpA) is a promising antimicrobial target that is a key protein component for two essential cellular processes, RNA degradation and transfer-RNA (tRNA) maturation. The first crystal structure of RnpA from the pathogenic bacterial species, S. aureus, is reported at 2.0 Å resolution. The structure presented maintains key similarities with previously reported RnpA structures from bacteria and archaea, including the highly conserved RNR-box region and aromatic residues in the precursor-tRNA 5′-leader-binding domain. This structure will be instrumental in the pursuit of structure-based designed inhibitors targeting RnpA-mediated RNA processing as a novel therapeutic approach for treating S. aureus infections.

scholarly journals Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus

Structure ◽  
2002 ◽  
Vol 10 (12) ◽  
pp. 1687-1696 ◽  
Author(s):  
Louise E Bird ◽  
Jingshan Ren ◽  
Jiancheng Zhang ◽  
Neale Foxwell ◽  
Alastair R Hawkins ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Nitric Oxide ◽  
Staphylococcus Aureus ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase

Preparation, Characterisation, Crystal Structure and Antibacterial Activity of two Bis-Schiff Bases Containing a Piperazine Ring

2018 ◽  
Vol 42 (10) ◽  
pp. 512-514
Author(s):  
Rui-bo Xu ◽  
Xiao-tian Yang ◽  
Hai-nan Li ◽  
Peng-cheng Zhao ◽  
Jiao-jiao Li ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Bacillus Subtilis ◽  
Schiff Bases ◽  
Piperazine Ring ◽  
X Ray ◽  
X Ray Crystallography ◽  
Good Antibacterial Activity

Two new bis-Schiff bases containing a piperazine ring, N,N‘-bis(4-chlorobenzylidene)- and N,N‘-bis(4-cyanobenzylidene)-1,4-bis(3-aminopropyl)piperazine, were prepared by the reaction of N,N‘-bis(3-aminopropyl)piperazine with 4-chloro- and 4-cyanobenzaldehyde, respectively. The dichloro compound was fully identified by X-ray crystallography and it exhibited good antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.

Crystal structure of Staphylococcus aureus Zn-glyoxalase I: new subfamily of glyoxalase I family

2017 ◽  
Vol 36 (2) ◽  
pp. 376-386 ◽  
Author(s):  
Yuri N. Chirgadze ◽  
Eugenia A. Boshkova ◽  
Kevin P. Battaile ◽  
Vitor G. Mendes ◽  
Robert Lam ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Staphylococcus Aureus ◽  
Glyoxalase I

Crystal structure and activities of three biscoumarin derivatives against Staphylococcus aureus

2015 ◽  
Vol 1097 ◽  
pp. 117-123 ◽  
Author(s):  
Fen Li ◽  
Chang-wei Lv ◽  
Zi-dan Zhang ◽  
Jing Li ◽  
Zheng Hou ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Staphylococcus Aureus

The 1.15Å Crystal Structure of the Staphylococcus aureus Methionyl-aminopeptidase and Complexes with Triazole Based Inhibitors

2003 ◽  
Vol 332 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Christian Oefner ◽  
Alice Douangamath ◽  
Allan D'Arcy ◽  
Sascha Häfeli ◽  
Daniel Mareque ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Staphylococcus Aureus ◽  
Methionyl Aminopeptidase
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