Programming asynchronous replication in stem cells

2017 ◽  
Vol 24 (12) ◽  
pp. 1132-1138 ◽  
Author(s):  
Hagit Masika ◽  
Marganit Farago ◽  
Merav Hecht ◽  
Reba Condiotti ◽  
Kirill Makedonski ◽  
...  
Keyword(s):  
Stem Cells ◽  
Asynchronous Replication

scholarly journals Asynchronous Replication and Autosome-Pair Non-Equivalence in Human Embryonic Stem Cells

PLoS ONE ◽  
2009 ◽  
Vol 4 (3) ◽  
pp. e4970 ◽  
Author(s):  
Devkanya Dutta ◽  
Alexander W. Ensminger ◽  
Jacob P. Zucker ◽  
Andrew Chess
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Asynchronous Replication ◽  
Autosome Pair

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Repair of deep skin burn defects with cultured epidermal stem cells and acellular amniotic membranes

2010 ◽  
Vol 34 (8) ◽  
pp. S39-S39
Author(s):  
Dewu Liu ◽  
Honglan Xiong ◽  
Yuangui Mao ◽  
Peixin Huang ◽  
Jianping Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Epidermal Stem Cells ◽  
Skin Burn ◽  
Amniotic Membranes

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent

Preliminary research of the aldosterone synthesized by bone morrow stem cells of adult male ratsin vitro

2010 ◽  
Vol 34 (8) ◽  
pp. S43-S43
Author(s):  
Wei‑ying Zou ◽  
Bei Yang ◽  
Xiuli Ni ◽  
Da‑lei Zhang ◽  
Lei Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Male ◽  
Preliminary Research ◽  
Bone Morrow

Centromere assembly and non-random sister chromatid segregation in stem cells

2020 ◽  
Vol 64 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Ben L. Carty ◽  
Elaine M. Dunleavy
Keyword(s):  
Stem Cells ◽  
Cell Division ◽  
Cell Fate ◽  
Sister Chromatid ◽  
Asymmetric Cell Division ◽  
Protein A ◽  
Germline Stem Cells ◽  
Sister Chromatids ◽  
Centromere Protein A ◽  
Oocyte Meiosis

Abstract Asymmetric cell division (ACD) produces daughter cells with separate distinct cell fates and is critical for the development and regulation of multicellular organisms. Epigenetic mechanisms are key players in cell fate determination. Centromeres, epigenetically specified loci defined by the presence of the histone H3-variant, centromere protein A (CENP-A), are essential for chromosome segregation at cell division. ACDs in stem cells and in oocyte meiosis have been proposed to be reliant on centromere integrity for the regulation of the non-random segregation of chromosomes. It has recently been shown that CENP-A is asymmetrically distributed between the centromeres of sister chromatids in male and female Drosophila germline stem cells (GSCs), with more CENP-A on sister chromatids to be segregated to the GSC. This imbalance in centromere strength correlates with the temporal and asymmetric assembly of the mitotic spindle and potentially orientates the cell to allow for biased sister chromatid retention in stem cells. In this essay, we discuss the recent evidence for asymmetric sister centromeres in stem cells. Thereafter, we discuss mechanistic avenues to establish this sister centromere asymmetry and how it ultimately might influence cell fate.

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