A cytosolic Ezh1 isoform modulates a PRC2–Ezh1 epigenetic adaptive response in postmitotic cells

2017 ◽  
Vol 24 (5) ◽  
pp. 444-452 ◽  
Author(s):  
Beatrice Bodega ◽  
Federica Marasca ◽  
Valeria Ranzani ◽  
Alessandro Cherubini ◽  
Francesco Della Valle ◽  
...  
Keyword(s):  
Adaptive Response ◽  
Postmitotic Cells

Cardiomyocyte dedifferentiation - A (mal)adaptive response to hypoxia

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
J. Pöling ◽  
T. Kubin ◽  
P. Gajawada ◽  
H. Lörchner ◽  
V. Polyakova ◽  
...  
Keyword(s):  
Adaptive Response

scholarly journals Coping with darkness: The adaptive response of marine picocyanobacteria to repeated light energy deprivation

2021 ◽  
Author(s):  
Allison Coe ◽  
Steven J. Biller ◽  
Elaina Thomas ◽  
Konstantinos Boulias ◽  
Christina Bliem ◽  
...  
Keyword(s):  
Adaptive Response ◽  
Light Energy ◽  
Energy Deprivation

scholarly journals Interhelical H-Bonds Modulate the Activity of a Polytopic Transmembrane Kinase

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 938
Author(s):  
Juan Cruz Almada ◽  
Ana Bortolotti ◽  
Jean Marie Ruysschaert ◽  
Diego de Mendoza ◽  
María Eugenia Inda ◽  
...  
Keyword(s):  
Histidine Kinase ◽  
Adaptive Response ◽  
Catalytic Domain ◽  
Membrane Lipids ◽  
Signal Transmission ◽  
Expression System ◽  
Lipid Homeostasis ◽  
Transmembrane Helices ◽  
Transmembrane Region

DesK is a Histidine Kinase that allows Bacillus subtilis to maintain lipid homeostasis in response to changes in the environment. It is located in the membrane, and has five transmembrane helices and a cytoplasmic catalytic domain. The transmembrane region triggers the phosphorylation of the catalytic domain as soon as the membrane lipids rigidify. In this research, we study how transmembrane inter-helical interactions contribute to signal transmission; we designed a co-expression system that allows studying in vivo interactions between transmembrane helices. By Alanine-replacements, we identified a group of polar uncharged residues, whose side chains contain hydrogen-bond donors or acceptors, which are required for the interaction with other DesK transmembrane helices; a particular array of H-bond- residues plays a key role in signaling, transmitting information detected at the membrane level into the cell to finally trigger an adaptive response.

scholarly journals How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 153
Author(s):  
Aslı Devrim-Lanpir ◽  
Lee Hill ◽  
Beat Knechtle
Keyword(s):  
Oxidative Stress ◽  
Oxidative Metabolism ◽  
Adaptive Response ◽  
Redox Regulation ◽  
Therapeutic Agent ◽  
Metabolic Effects ◽  
Metabolic Adaptations ◽  
Current Perspective ◽  
Exercise Induced ◽  
Response To Exercise

Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant. Several studies have investigated NAC’s possible therapeutic role in oxidative metabolism and adaptive response to exercise in the athletic population. However, still conflicting questions regarding NAC supplementation need to be clarified. This narrative review aims to re-evaluate the metabolic effects of NAC on exercise-induced oxidative stress and adaptive response developed by athletes against the exercise, especially mitohormetic and sarcohormetic response.

Molecular mechanisms involved in the adaptive response to cadmium-induced apoptosis in human myelomonocytic lymphoma U937 cells

2011 ◽  
Vol 25 (8) ◽  
pp. 1687-1693 ◽  
Author(s):  
Zheng-Guo Cui ◽  
Ryohei Ogawa ◽  
Jin-Lan Piao ◽  
Kei Hamazaki ◽  
Loreto B. Feril ◽  
...  
Keyword(s):  
Adaptive Response ◽  
Molecular Mechanisms ◽  
U937 Cells ◽  
Induced Apoptosis
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