A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

John G Menting; Joanna Gajewiak; Christopher A MacRaild; Danny Hung-Chieh Chou; Maria M Disotuar; Nicholas A Smith; Charleen Miller; Judit Erchegyi; Jean E Rivier; Baldomero M Olivera; Briony E Forbes; Brian J Smith; Raymond S Norton; Helena Safavi-Hemami; Michael C Lawrence

doi:10.1038/nsmb.3292

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Nature Structural & Molecular Biology ◽

10.1038/nsmb.3292 ◽

2016 ◽

Vol 23 (10) ◽

pp. 916-920 ◽

Cited By ~ 37

Author(s):

John G Menting ◽

Joanna Gajewiak ◽

Christopher A MacRaild ◽

Danny Hung-Chieh Chou ◽

Maria M Disotuar ◽

...

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Receptor Binding ◽

Binding Motif ◽

Insulin Receptor Binding ◽

Human Insulin Receptor

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Mutation of the High Cysteine Region of the Human Insulin Receptor α-Subunit Increases Insulin Receptor Binding Affinity and Transmembrane Signaling

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)71563-9 ◽

1989 ◽

Vol 264 (27) ◽

pp. 15900-15904 ◽

Cited By ~ 4

Author(s):

R Rafaeloff ◽

R Patel ◽

C Yip ◽

I D Goldfine ◽

D M Hawley

Keyword(s):

Insulin Receptor ◽

Binding Affinity ◽

Human Insulin ◽

Receptor Binding ◽

Transmembrane Signaling ◽

Α Subunit ◽

Receptor Binding Affinity ◽

Insulin Receptor Binding ◽

Human Insulin Receptor

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Insulin Receptor Binding in Pork Brain: Different Affinities of Porcine and Human Insulin

Hormone and Metabolic Research ◽

10.1055/s-2007-1014805 ◽

1984 ◽

Vol 16 (08) ◽

pp. 411-414 ◽

Cited By ~ 4

Author(s):

K. Schlüter ◽

Jutta André ◽

F. Enzmann ◽

L. Kerp

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Receptor Binding ◽

Insulin Receptor Binding

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Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes

Genetics and Molecular Research ◽

10.4238/2015.august.3.5 ◽

2015 ◽

Vol 14 (3) ◽

pp. 8819-8828 ◽

Cited By ~ 3

Author(s):

J. Wang ◽

T. Zou ◽

H.X. Yang ◽

Y.Z. Gong ◽

X.J. Xie ◽

...

Keyword(s):

Insulin Receptor ◽

Receptor Binding ◽

Akt Signaling ◽

Binding Motif ◽

Insulin Sensitizer ◽

Insulin Receptor Binding

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Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction

Diabetes ◽

10.2337/diabetes.39.1.123 ◽

1990 ◽

Vol 39 (1) ◽

pp. 123-128 ◽

Cited By ~ 16

Author(s):

S. Seino ◽

M. Seino ◽

G. I. Bell

Keyword(s):

Polymerase Chain Reaction ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Gene ◽

Partial Sequence ◽

Chain Reaction ◽

Insulin Receptor Gene ◽

Human Insulin Receptor ◽

Polymerase Chain

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Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)30636-1 ◽

1990 ◽

Vol 265 (31) ◽

pp. 19143-19150

Author(s):

T Kadowaki ◽

H Kadowaki ◽

D Accili ◽

S.I. Taylor

Keyword(s):

Cell Surface ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Alpha Subunit ◽

Human Insulin Receptor

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Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)46967-0 ◽

1994 ◽

Vol 269 (44) ◽

pp. 27186-27192

Author(s):

P A Staubs ◽

D R Reichart ◽

A R Saltiel ◽

K L Milarski ◽

H Maegawa ◽

...

Keyword(s):

Insulin Receptor ◽

Receptor Binding ◽

Binding Sites ◽

Sh2 Domain ◽

Insulin Receptor Binding

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Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38291-2 ◽

1990 ◽

Vol 265 (22) ◽

pp. 13248-13253 ◽

Cited By ~ 1

Author(s):

E M Schaefer ◽

K Siddle ◽

L Ellis

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Deletion Analysis ◽

Alpha Subunit ◽

Human Insulin Receptor

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Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)50389-1 ◽

1992 ◽

Vol 267 (13) ◽

pp. 9065-9070

Author(s):

Y Takata ◽

N.J. Webster ◽

J.M. Olefsky

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Intracellular Signaling ◽

Human Insulin Receptor ◽

Carboxyl Terminal ◽

Tyrosine Autophosphorylation

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Identification of retinal insulin receptors using site-specific antibodies to a carboxyl-terminal peptide of the human insulin receptor alpha-subunit. Up-regulation of neuronal insulin receptors in diabetes.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)38266-8 ◽

1990 ◽

Vol 265 (29) ◽

pp. 18030-18034

Author(s):

S A Rosenzweig ◽

C Zetterström ◽

A Benjamin

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Receptors ◽

Alpha Subunit ◽

Site Specific ◽

Specific Antibodies ◽

Receptor Alpha ◽

Human Insulin Receptor ◽

Carboxyl Terminal

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Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)61322-5 ◽

1987 ◽

Vol 262 (9) ◽

pp. 4134-4140 ◽

Cited By ~ 11

Author(s):

J.R. Forsayeth ◽

A. Montemurro ◽

B.A. Maddux ◽

R. DePirro ◽

I.D. Goldfine

Keyword(s):

Monoclonal Antibodies ◽

Insulin Receptor ◽

Human Insulin ◽

Negative Cooperativity ◽

Down Regulation ◽

Human Insulin Receptor

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