scholarly journals Prophylactic ART in HIV serodiscordant couples

2016 ◽  
Vol 13 (9) ◽  
pp. 495-495
Author(s):  
Annette Fenner
Keyword(s):  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples

Safer conception options for HIV-serodiscordant couples

2012 ◽  
Vol 206 (1) ◽  
pp. e21 ◽  
Author(s):  
Deborah Cohan ◽  
Shannon Weber ◽  
Ronald Goldschmidt
Keyword(s):  
Safer Conception ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples

Couple-Focused Interventions for HIV-Serodiscordant Couples During Transition to Motherhood

2011 ◽  
Vol 33 (2) ◽  
pp. 143-160 ◽  
Author(s):  
Marco Pereira ◽  
Frank M. Dattilio ◽  
Maria Cristina Canavarro ◽  
Isabel Narciso
Keyword(s):  
Serodiscordant Couples ◽  
Transition To Motherhood ◽  
Hiv Serodiscordant Couples

scholarly journals Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa

2018 ◽  
Vol 1 ◽  
pp. 3 ◽  
Author(s):  
Renee Heffron ◽  
Kenneth Ngure ◽  
Josephine Odoyo ◽  
Nulu Bulya ◽  
Edna Tindimwebwa ◽  
...  
Keyword(s):  
Hiv Infections ◽  
Hiv Treatment ◽  
Demonstration Project ◽  
Hiv Incidence ◽  
Serodiscordant Couples ◽  
Treatment Services ◽  
Hiv Serodiscordant Couples ◽  
Exposure Prophylaxis ◽  
Living With Hiv ◽  
Hiv Negative

Background: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial HIV risk.  Demonstration projects conducted in diverse settings worldwide illustrate practical examples of how PrEP can be delivered. This manuscript presents estimates of effectiveness and patterns of PrEP use within a two-year demonstration project of PrEP for HIV-negative members of heterosexual HIV serodiscordant couples in East Africa. Methods: The PrEP delivery model integrated PrEP into HIV treatment services, prioritizing PrEP use for HIV-negative partners within serodiscordant couples before and during the first 6 months after the partner living with HIV initiated antiretroviral therapy (ART).  We measured PrEP uptake through pharmacy records and adherence to PrEP through medication event monitoring system (MEMS) bottle caps and quantification of tenofovir in plasma among a random sample of participants. We estimated HIV infections prevented using a counterfactual cohort simulated from the placebo arm of a previous PrEP clinical trial. Results: We enrolled 1,010 HIV serodiscordant couples that were naïve to ART and PrEP.  Ninety-seven percent of HIV-negative partners initiated PrEP. Objective measures suggest high adherence: 71% of HIV-negative participants took ≥80% of expected doses, as recorded via MEMS, and 81% of plasma samples had tenofovir detected.  Four incident HIV infections were observed (incidence rate=0.24 per 100 person-years), a 95% reduction (95% CI 86-98%, p<0.0001) in HIV incidence, relative to estimated HIV incidence for the population in the absence of PrEP integrated into HIV treatment services.   Conclusions: PrEP uptake and adherence were high and incident HIV was rare in this PrEP demonstration project for African HIV-negative individuals whose partners were known to be living with HIV.  Delivery of PrEP to HIV-negative partners within HIV serodiscordant couples was feasible and should be prioritized for wide-scale implementation.

scholarly journals A scoping review and thematic analysis of social and behavioural research among HIV-serodiscordant couples in high-income settings

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Joshua B Mendelsohn ◽  
Liviana Calzavara ◽  
Amrita Daftary ◽  
Sanjana Mitra ◽  
Joel Pidutti ◽  
...  
Keyword(s):  
Thematic Analysis ◽  
Scoping Review ◽  
High Income ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples ◽  
Behavioural Research

scholarly journals Risky Sex and HIV Acquisition Among HIV Serodiscordant Couples in Zambia, 2002–2012: What Does Alcohol Have To Do With It?

2017 ◽  
Vol 21 (7) ◽  
pp. 1892-1903 ◽  
Author(s):  
Dvora Joseph Davey ◽  
William Kilembe ◽  
Kristin M. Wall ◽  
Naw Htee Khu ◽  
Ilene Brill ◽  
...  
Keyword(s):  
Risky Sex ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples ◽  
Hiv Acquisition

scholarly journals Difficult decisions: Evaluating individual and couple-level fertility intentions and HIV acquisition among HIV serodiscordant couples in Zambia

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0189869 ◽  
Author(s):  
Dvora Leah Joseph Davey ◽  
Kristin M. Wall ◽  
William Kilembe ◽  
Naw Htee Khu ◽  
Ilene Brill ◽  
...  
Keyword(s):  
Fertility Intentions ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples ◽  
Hiv Acquisition
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