scholarly journals Localization and function of the renal calcium-sensing receptor

2016 ◽  
Vol 12 (7) ◽  
pp. 414-425 ◽  
Author(s):  
Daniela Riccardi ◽  
Giovanna Valenti
Keyword(s):  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
And Function

Expression and function of the calcium sensing receptor (CaR) in gastrinomas

2000 ◽  
Vol 118 (4) ◽  
pp. A297
Author(s):  
Stephan U. Goebel ◽  
Paolo L. Peghini ◽  
Paul Goldsmith ◽  
Allen M. Spiegel ◽  
Fathia Gibril ◽  
...  
Keyword(s):  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
And Function

scholarly journals Regulation of E-cadherin and β-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function

2007 ◽  
Vol 121 (7) ◽  
pp. 1455-1462 ◽  
Author(s):  
Narasimharao Bhagavathula ◽  
Andrew W. Hanosh ◽  
Kamalakar C. Nerusu ◽  
Henry Appelman ◽  
Subhas Chakrabarty ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Receptor Expression ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
And Function ◽  
E Cadherin

scholarly journals Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle

2021 ◽  
Vol 22 (14) ◽  
pp. 7282
Author(s):  
Cecilia Romagnoli ◽  
Preeti Sharma ◽  
Roberto Zonefrati ◽  
Gaia Palmini ◽  
Elena Lucattelli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cells ◽  
Human Skeletal Muscle ◽  
Myogenic Differentiation ◽  
Physiological Role ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Muscle Tissues ◽  
And Function

Skeletal muscle has an outstanding capacity for regeneration in response to injuries, but there are disorders in which this process is seriously impaired, such as sarcopenia. Pharmacological treatments to restore muscle trophism are not available, therefore, the identification of suitable therapeutic targets that could be useful for the treatment of skeletal reduced myogenesis is highly desirable. In this in vitro study, we explored the expression and function of the calcium-sensing receptor (CaSR) in human skeletal muscle tissues and their derived satellite cells. The results obtained from analyses with various techniques of gene and protein CaSR expression and of its secondary messengers in response to calcium (Ca2+) and CaSR drugs have demonstrated that this receptor is not present in human skeletal muscle tissues, neither in the established satellite cells, nor during in vitro myogenic differentiation. Taken together, our data suggest that, although CaSR is a very important drug target in physiology and pathology, this receptor probably does not have any physiological role in skeletal muscle in normal conditions.

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