Increased complexity of the glomerular extracellular matrix

2014 ◽  
Vol 10 (3) ◽  
pp. 126-126
Author(s):  
David Holmes
Keyword(s):  
Extracellular Matrix ◽  
Glomerular Extracellular Matrix

scholarly journals Glomerular Extracellular Matrix Components and Integrins

1998 ◽  
Vol 5 (3) ◽  
pp. 177-192 ◽  
Author(s):  
Lotus M. Th Sterk ◽  
Annemieke A. De Melker ◽  
Duco Kramer ◽  
Ingrid Kuikman ◽  
Anwar Chand ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Components ◽  
Matrix Components ◽  
Glomerular Extracellular Matrix

scholarly journals Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Flavia Teodora Ioana Paunas ◽  
Kenneth Finne ◽  
Sabine Leh ◽  
Tarig Al-Hadi Osman ◽  
Hans-Peter Marti ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Iga Nephropathy ◽  
Matrix Protein ◽  
Fold Change ◽  
Matrix Metalloproteinase 2 ◽  
Extracellular Matrix Protein ◽  
Glomerular Sclerosis ◽  
Matrix Expansion ◽  
Glomerular Extracellular Matrix

Abstract Background IgA nephropathy (IgAN) involves mesangial matrix expansion, but the proteomic composition of this matrix is unknown. The present study aimed to characterize changes in extracellular matrix in IgAN. Methods In the present study we used mass spectrometry-based proteomics in order to quantitatively compare protein abundance between glomeruli of patients with IgAN (n = 25) and controls with normal biopsy findings (n = 15). Results Using a previously published paper by Lennon et al. and cross-referencing with the Matrisome database we identified 179 extracellular matrix proteins. In the comparison between IgAN and controls, IgAN glomeruli showed significantly higher abundance of extracellular matrix structural proteins (e.g periostin, vitronectin, and extracellular matrix protein 1) and extracellular matrix associated proteins (e.g. azurocidin, myeloperoxidase, neutrophil elastase, matrix metalloproteinase-9 and matrix metalloproteinase 2). Periostin (fold change 3.3) and azurocidin (3.0) had the strongest fold change between IgAN and controls; periostin was also higher in IgAN patients who progressed to ESRD as compared to patients who did not. Conclusion IgAN is associated with widespread changes of the glomerular extracellular matrix proteome. Proteins important in glomerular sclerosis or inflammation seem to be most strongly increased and periostin might be an important marker of glomerular damage in IgAN.

scholarly journals Characterization of glomerular extracellular matrix by proteomic analysis of laser-captured microdissected glomeruli

2017 ◽  
Vol 91 (2) ◽  
pp. 501-511 ◽  
Author(s):  
Liliane Hobeika ◽  
Michelle T. Barati ◽  
Dawn J. Caster ◽  
Kenneth R. McLeish ◽  
Michael L. Merchant
Keyword(s):  
Extracellular Matrix ◽  
Proteomic Analysis ◽  
Glomerular Extracellular Matrix

Glomerular extracellular matrix and growth factors in diffuse mesangial sclerosis

2001 ◽  
Vol 16 (5) ◽  
pp. 429-438 ◽  
Author(s):  
Youxin Yang ◽  
Shao-yu Zhang ◽  
Mireille Sich ◽  
Agnès Béziau ◽  
Lambert P. W. J. van den Heuvel ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factors ◽  
Diffuse Mesangial Sclerosis ◽  
Glomerular Extracellular Matrix

scholarly journals Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization

2015 ◽  
Vol 26 (12) ◽  
pp. 3021-3034 ◽  
Author(s):  
Michael J. Randles ◽  
Adrian S. Woolf ◽  
Jennifer L. Huang ◽  
Adam Byron ◽  
Jonathan D. Humphries ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Genetic Background ◽  
Matrix Composition ◽  
Glomerular Extracellular Matrix
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