scholarly journals Correction: The high-conductance state of neocortical neurons in vivo

2003 ◽  
Vol 4 (12) ◽  
pp. 1019-1019 ◽  
Author(s):  
Alain Destexhe ◽  
Michael Rudolph ◽  
Denis Paré
Keyword(s):  
Neocortical Neurons ◽  
High Conductance State ◽  
Conductance State ◽  
High Conductance

The high-conductance state of neocortical neurons in vivo

2003 ◽  
Vol 4 (9) ◽  
pp. 739-751 ◽  
Author(s):  
Alain Destexhe ◽  
Michael Rudolph ◽  
Denis Paré
Keyword(s):  
Neocortical Neurons ◽  
High Conductance State ◽  
Conductance State ◽  
High Conductance

scholarly journals Synaptic plasticity through activation of GluA3-containing AMPA-receptors

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Maria C Renner ◽  
Eva HH Albers ◽  
Nicolas Gutierrez-Castellanos ◽  
Niels R Reinders ◽  
Aile N van Huijstee ◽  
...  
Keyword(s):  
Ampa Receptors ◽  
Adrenergic Receptors ◽  
Pyramidal Neurons ◽  
Synaptic Potentiation ◽  
High Conductance State ◽  
Hippocampal Synapses ◽  
Β Adrenergic Receptors ◽  
Camp Levels ◽  
Conductance State ◽  
High Conductance

Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types of AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), and those that contain GluA2 and GluA3 (GluA2/3). Whereas subunits GluA1 and GluA2 have been extensively studied, the contribution of GluA3 to synapse physiology has remained unclear. Here we show in mice that GluA2/3s are in a low-conductance state under basal conditions, and although present at synapses they contribute little to synaptic currents. When intracellular cyclic AMP (cAMP) levels rise, GluA2/3 channels shift to a high-conductance state, leading to synaptic potentiation. This cAMP-driven synaptic potentiation requires the activation of both protein kinase A (PKA) and the GTPase Ras, and is induced upon the activation of β-adrenergic receptors. Together, these experiments reveal a novel type of plasticity at CA1 hippocampal synapses that is expressed by the activation of GluA3-containing AMPARs.

Characterization of Synaptic Conductances and Integrative Properties During Electrically Induced EEG-Activated States in Neocortical Neurons In Vivo

2005 ◽  
Vol 94 (4) ◽  
pp. 2805-2821 ◽  
Author(s):  
Michael Rudolph ◽  
Joe Guillaume Pelletier ◽  
Denis Paré ◽  
Alain Destexhe
Keyword(s):  
Cortical Neurons ◽  
Computational Models ◽  
Input Resistance ◽  
Synaptic Activity ◽  
Intracellular Recordings ◽  
Neocortical Neurons ◽  
Up States ◽  
Conductance State ◽  
Stimulation Of

The activation of the electroencephalogram (EEG) is paralleled with an increase in the firing rate of cortical neurons, but little is known concerning the conductance state of their membrane and its impact on their integrative properties. Here, we combined in vivo intracellular recordings with computational models to investigate EEG-activated states induced by stimulation of the brain stem ascending arousal system. Electrical stimulation of the pedonculopontine tegmental (PPT) nucleus produced long-lasting (≈20 s) periods of desynchronized EEG activity similar to the EEG of awake animals. Intracellularly, PPT stimulation locked the membrane into a depolarized state, similar to the up-states seen during deep anesthesia. During these EEG-activated states, however, the input resistance was higher than that during up-states. Conductance measurements were performed using different methods, which all indicate that EEG-activated states were associated with a synaptic activity dominated by inhibitory conductances. These results were confirmed by computational models of reconstructed pyramidal neurons constrained by the corresponding intracellular recordings. These models indicate that, during EEG-activated states, neocortical neurons are in a high-conductance state consistent with a stochastic integrative mode. The amplitude and timing of somatic excitatory postsynaptic potentials were nearly independent of the position of the synapses in dendrites, suggesting that EEG-activated states are compatible with coding paradigms involving the precise timing of synaptic events.

scholarly journals Stochastic inference with spiking neurons in the high-conductance state

2016 ◽  
Vol 94 (4) ◽  
Author(s):  
Mihai A. Petrovici ◽  
Johannes Bill ◽  
Ilja Bytschok ◽  
Johannes Schemmel ◽  
Karlheinz Meier
Keyword(s):  
Spiking Neurons ◽  
High Conductance State ◽  
Stochastic Inference ◽  
Conductance State ◽  
High Conductance

scholarly journals High-conductance state

Scholarpedia ◽  
2007 ◽  
Vol 2 (11) ◽  
pp. 1341 ◽  
Author(s):  
Alain Destexhe
Keyword(s):  
High Conductance State ◽  
Conductance State ◽  
High Conductance

Is the mammalian porin channel, VDAC, a perfect cylinder in the high conductance state?

FEBS Letters ◽  
1997 ◽  
Vol 416 (2) ◽  
pp. 187-189 ◽  
Author(s):  
C.M.M Carneiro ◽  
O.V Krasilnikov ◽  
L.N Yuldasheva ◽  
A.C Campos de Carvalho ◽  
R.A Nogueira
Keyword(s):  
High Conductance State ◽  
Conductance State ◽  
High Conductance
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