scholarly journals Viral subversion of the host protein synthesis machinery

2011 ◽  
Vol 9 (12) ◽  
pp. 860-875 ◽  
Author(s):  
Derek Walsh ◽  
Ian Mohr
Keyword(s):  
Protein Synthesis ◽  
Host Protein ◽  
Protein Synthesis Machinery ◽  
Host Protein Synthesis

scholarly journals A novel vibriophage exhibits inhibitory activity against host protein synthesis machinery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Khrongkhwan Thammatinna ◽  
MacKennon E. Egan ◽  
Htut Htut Htoo ◽  
Kanika Khanna ◽  
Joseph Sugie ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Inhibitory Activity ◽  
Host Protein ◽  
Protein Synthesis Machinery ◽  
Host Protein Synthesis

scholarly journals Inhibition of Host Protein Synthesis and Degradation of Cellular mRNAs During Infection by Influenza and Herpes Simplex Virus

1982 ◽  
Vol 2 (12) ◽  
pp. 1644-1648 ◽  
Author(s):  
S. C. Inglis
Keyword(s):  
Protein Synthesis ◽  
Blot Hybridization ◽  
Host Protein ◽  
Cell Protein ◽  
Cellular Genes ◽  
Cellular Mrnas ◽  
The Stability ◽  
Simplex Virus ◽  
Host Protein Synthesis ◽  
Synthesis And Degradation

Cloned DNA copies of two cellular genes were used to monitor, by blot hybridization, the stability of particular cell mRNAs after infection by influenza virus and herpesvirus. The results indicated that the inhibition of host cell protein synthesis that accompanied infection by each virus could be explained by a reduction in the amounts of cellular mRNAs in the cytoplasm, and they suggested that this decrease was due to virus-mediated mRNA degradation.

Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus-infected cells

Virology ◽  
1989 ◽  
Vol 168 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Robert P. O'Malley ◽  
Roger F. Duncan ◽  
John W.B. Hershey ◽  
Michael B. Mathews
Keyword(s):  
Protein Synthesis ◽  
Host Protein ◽  
Initiation Factors ◽  
Infected Cells ◽  
Protein Synthesis Initiation ◽  
Host Protein Synthesis

scholarly journals The dynamics of coiled bodies in the nucleus of adenovirus-infected cells.

1996 ◽  
Vol 7 (7) ◽  
pp. 1137-1151 ◽  
Author(s):  
L Rebelo ◽  
F Almeida ◽  
C Ramos ◽  
K Bohmann ◽  
A I Lamond ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Hela Cells ◽  
Host Protein ◽  
Coiled Body ◽  
Adenovirus Infection ◽  
Protein Synthesis Inhibitors ◽  
Coiled Bodies ◽  
Infected Cells ◽  
Host Protein Synthesis ◽  
Small Nuclear Ribonucleoproteins

The coiled body is a specific intranuclear structure of unknown function that is enriched in splicing small nuclear ribonucleoproteins (snRNPs). Because adenoviruses make use of the host cell-splicing machinery and subvert the normal subnuclear organization, we initially decided to investigate the effect of adenovirus infection on the coiled body. The results indicate that adenovirus infection induces the disassembly of coiled bodies and that this effect is probably secondary to the block of host protein synthesis induced by the virus. Furthermore, coiled bodies are shown to be very labile structures, with a half-life of approximately 2 h after treatment of HeLa cells with protein synthesis inhibitors. After blocking of protein synthesis, p80 coilin was detected in numerous microfoci that do not concentrate snRNP. These structures may represent precursor forms of the coiled body, which goes through a rapid cycle of assembly/disassembly in the nucleus and requires ongoing protein synthesis to reassemble.

Sign in / Sign up

Export Citation Format

Share Document