scholarly journals Transcriptional mutagenesis by R-loops

2015 ◽  
Vol 17 (1) ◽  
pp. 3-3
Author(s):  
Eytan Zlotorynski
Keyword(s):  
Transcriptional Mutagenesis

scholarly journals RNA polymerase bypass at sites of dihydrouracil: implications for transcriptional mutagenesis.

1995 ◽  
Vol 15 (12) ◽  
pp. 6729-6735 ◽  
Author(s):  
J Liu ◽  
W Zhou ◽  
P W Doetsch
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerases ◽  
Dna Damages ◽  
Mutant Proteins ◽  
Dna Lesion ◽  
Transcriptional Mutagenesis ◽  
Rapid Generation ◽  
Transition Mutation

Dihydrouracil (DHU) is a major base damage product formed from cytosine following exposure of DNA to ionizing radiation under anoxic conditions. To gain insight into the DNA lesion structural requirements for RNA polymerase arrest or bypass at various DNA damages located on the transcribed strand during elongation, DHU was placed onto promoter-containing DNA templates 20 nucleotides downstream from the transcription start site. In vitro, single-round transcription experiments carried out with SP6 and T7 RNA polymerases revealed that following a brief pause at the DHU site, both enzymes efficiently bypass this lesion with subsequent rapid generation of full-length runoff transcripts. Direct sequence analysis of these transcripts indicated that both RNA polymerases insert primarily adenine opposite to the DHU site, resulting in a G-to-A transition mutation in the lesion bypass product. Such bypass and insertion events at DHU sites (or other types of DNA damages), if they occur in vivo, have a number of important implications for both the repair of such lesions and the DNA damage-induced production of mutant proteins at the level of transcription (transcriptional mutagenesis).

scholarly journals Transcriptional mutagenesis: causes and involvement in tumour development

2011 ◽  
Vol 11 (3) ◽  
pp. 218-227 ◽  
Author(s):  
Damien Brégeon ◽  
Paul W. Doetsch
Keyword(s):  
Tumour Development ◽  
Transcriptional Mutagenesis

scholarly journals Abasic sites and strand breaks in DNA cause transcriptional mutagenesis inEscherichia coli

2010 ◽  
Vol 107 (8) ◽  
pp. 3657-3662 ◽  
Author(s):  
Cheryl L. Clauson ◽  
Kenneth J. Oestreich ◽  
James W. Austin ◽  
Paul W. Doetsch
Keyword(s):  
Inescherichia Coli ◽  
Strand Breaks ◽  
Abasic Sites ◽  
Transcriptional Mutagenesis

scholarly journals Reverse transcriptional mutagenesis induced by ribonucleoside triphosphate analogue, PTP and its availability for anti-HIV-1 therapy

2001 ◽  
Vol 1 (1) ◽  
pp. 255-256
Author(s):  
K. Moriyama ◽  
T. Okada ◽  
D. Loakes ◽  
N. Miyano-Kurosaki ◽  
H. Takaku ◽  
...  
Keyword(s):  
Transcriptional Mutagenesis ◽  
Ribonucleoside Triphosphate ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis

PLoS Genetics ◽  
2006 ◽  
Vol 2 (11) ◽  
pp. e176 ◽  
Author(s):  
Claire Hoede ◽  
Erick Denamur ◽  
Olivier Tenaillon
Keyword(s):  
Secondary Structures ◽  
Transcriptional Mutagenesis ◽  
Dna Secondary Structures

scholarly journals Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shuo Liang ◽  
Monika Ezerskyte ◽  
Jingwen Wang ◽  
Vicent Pelechano ◽  
Kristian Dreij
Keyword(s):  
Genome Wide ◽  
Transcriptional Mutagenesis

scholarly journals Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis

DNA Repair ◽  
2014 ◽  
Vol 19 ◽  
pp. 71-83 ◽  
Author(s):  
Liang Xu ◽  
Linati Da ◽  
Steven W. Plouffe ◽  
Jenny Chong ◽  
Eric Kool ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Dna Lesion ◽  
Transcriptional Mutagenesis
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