scholarly journals Regulating the adaptive immune response to respiratory virus infection

2012 ◽  
Vol 12 (4) ◽  
pp. 295-305 ◽  
Author(s):  
Thomas J. Braciale ◽  
Jie Sun ◽  
Taeg S. Kim
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Respiratory Virus ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Respiratory Virus Infection

scholarly journals Evolution of the innate and adaptive immune response in women with acute Zika virus infection

2019 ◽  
Vol 5 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Pierre Tonnerre ◽  
Juliana G. Melgaço ◽  
Almudena Torres-Cornejo ◽  
Marcelo A. Pinto ◽  
Constanze Yue ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Zika Virus ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Zika Virus Infection

scholarly journals Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination

2016 ◽  
Vol 170 ◽  
pp. 9-19 ◽  
Author(s):  
Kaushiki Biswas ◽  
Dhriti Chatterjee ◽  
Sankar Addya ◽  
Reas S. Khan ◽  
Lawrence C. Kenyon ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Hepatitis Virus ◽  
Mouse Hepatitis Virus ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Hepatitis Virus Infection

scholarly journals Chronic Joint Disease Caused by Persistent Chikungunya Virus Infection Is Controlled by the Adaptive Immune Response

2013 ◽  
Vol 87 (24) ◽  
pp. 13878-13888 ◽  
Author(s):  
D. W. Hawman ◽  
K. A. Stoermer ◽  
S. A. Montgomery ◽  
P. Pal ◽  
L. Oko ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Chikungunya Virus ◽  
Adaptive Immune Response ◽  
Joint Disease ◽  
Adaptive Immune

scholarly journals Plasticity and Virus Specificity of the Airway Epithelial Cell Immune Response during Respiratory Virus Infection

2012 ◽  
Vol 86 (10) ◽  
pp. 5422-5436 ◽  
Author(s):  
I. Ioannidis ◽  
B. McNally ◽  
M. Willette ◽  
M. E. Peeples ◽  
D. Chaussabel ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cell ◽  
Virus Infection ◽  
Respiratory Virus ◽  
Airway Epithelial Cell ◽  
Cell Immune Response ◽  
Airway Epithelial ◽  
Respiratory Virus Infection

scholarly journals Human Dendritic Cells Are Activated by Dengue Virus Infection: Enhancement by Gamma Interferon and Implications for Disease Pathogenesis

2001 ◽  
Vol 75 (8) ◽  
pp. 3501-3508 ◽  
Author(s):  
Daniel H. Libraty ◽  
Sathit Pichyangkul ◽  
Chuanpis Ajariyakhajorn ◽  
Timothy P. Endy ◽  
Francis A. Ennis
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Adaptive Immune Response ◽  
Interleukin 12 ◽  
Cell Mediated Immunity ◽  
Dengue Virus Infection ◽  
Adaptive Immune ◽  
Ifn Γ

ABSTRACT The ability of dendritic cells (DCs) to shape the adaptive immune response to viral infection is mediated largely by their maturation and activation state as determined by the surface expression of HLA molecules, costimulatory molecules, and cytokine production. Dengue is an emerging arboviral disease where the severity of illness is influenced by the adaptive immune response to the virus. In this report, we have demonstrated that dengue virus infects and replicates in immature human myeloid DCs. Exposure to live dengue virus led to maturation and activation of both the infected and surrounding, uninfected DCs and stimulated production of tumor necrosis factor alpha (TNF-α) and alpha interferon (IFN-α). Activation of the dengue virus-infected DCs was blunted compared to the surrounding, uninfected DCs, and dengue virus infection induced low-level release of interleukin-12 p70 (IL-12 p70), a key cytokine in the development of cell-mediated immunity (CMI). Upon the addition of IFN-γ, there was enhanced activation of dengue virus-infected DCs and enhanced dengue virus-induced IL-12 p70 release. The data suggest a model whereby DCs are the early, primary target of dengue virus in natural infection and the vigor of CMI is modulated by the relative presence or absence of IFN-γ in the microenvironment surrounding the virus-infected DCs. These findings are relevant to understanding the pathogenesis of dengue hemorrhagic fever and the design of new vaccination and therapeutic strategies.

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