Regulating antigen-receptor gene assembly

2003 ◽  
Vol 3 (11) ◽  
pp. 890-899 ◽  
Author(s):  
Mark S. Schlissel
Keyword(s):  
Receptor Gene ◽  
Antigen Receptor ◽  
Gene Assembly

scholarly journals Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly

Oncogene ◽  
2007 ◽  
Vol 26 (56) ◽  
pp. 7759-7764 ◽  
Author(s):  
E Callén ◽  
M C Nussenzweig ◽  
A Nussenzweig
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Receptor Gene ◽  
Antigen Receptor ◽  
Cell Cycle Checkpoints ◽  
Gene Assembly

scholarly journals Genome Topology Control of Antigen Receptor Gene Assembly

2020 ◽  
Vol 204 (10) ◽  
pp. 2617-2626 ◽  
Author(s):  
Brittney M. Allyn ◽  
Kyutae D. Lee ◽  
Craig H. Bassing
Keyword(s):  
Topology Control ◽  
Receptor Gene ◽  
Antigen Receptor ◽  
Gene Assembly

The mechanism of antigen receptor gene assembly

Cell ◽  
1989 ◽  
Vol 59 (4) ◽  
pp. 585-588 ◽  
Author(s):  
Susanna Lewis ◽  
Martin Gellert
Keyword(s):  
Receptor Gene ◽  
Antigen Receptor ◽  
Gene Assembly

Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys

2020 ◽  
Vol 5 (45) ◽  
pp. eaba0925 ◽  
Author(s):  
Ryo Morimoto ◽  
Connor P. O’Meara ◽  
Stephen J. Holland ◽  
Inês Trancoso ◽  
Ahmed Souissi ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Cytidine Deaminase ◽  
Receptor Gene ◽  
Cell Lineage ◽  
Antigen Receptor ◽  
Immunoglobulin Gene ◽  
Gene Assembly ◽  
Lampetra Planeri ◽  
B Lymphocyte Development ◽  
Somatic Diversification

The antibodies of jawless vertebrates consist of leucine-rich repeat arrays encoded by somatically assembled VLRB genes. It is unknown how the incomplete germline VLRB loci are converted into functional antibody genes during B lymphocyte development in lampreys. In Lampetra planeri larvae lacking the cytidine deaminase CDA2 gene, VLRB assembly fails, whereas the T lineage–associated VLRA and VLRC antigen receptor gene assemblies occur normally. Thus, CDA2 acts in a B cell lineage–specific fashion to support the somatic diversification of VLRB antibody genes. CDA2 is closely related to activation-induced cytidine deaminase (AID), which is essential for the elaboration of immunoglobulin gene repertoires in jawed vertebrates. Our results thus identify a convergent mechanism of antigen receptor gene assembly and diversification that independently evolved in the two sister branches of vertebrates.

scholarly journals Regulation of antigen‐receptor gene assembly in hagfish

EMBO Reports ◽  
2010 ◽  
Vol 11 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Natsuko Kishishita ◽  
Tatsuya Matsuno ◽  
Yoshimasa Takahashi ◽  
Hiroyuki Takaba ◽  
Hirofumi Nishizumi ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Antigen Receptor ◽  
Gene Assembly
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