scholarly journals Designer plant miRNAs meet their targets

2006 ◽  
Vol 7 (5) ◽  
pp. 335-335
Author(s):  
Jenny Bangham
Keyword(s):  
Plant Mirnas

MicroRNA annotation in plants: current status and challenges

2021 ◽  
Author(s):  
Yongxin Zhao ◽  
Zheng Kuang ◽  
Ying Wang ◽  
Lei Li ◽  
Xiaozeng Yang
Keyword(s):  
Small Rna ◽  
Signal To Noise Ratio ◽  
Current Status ◽  
Mirna Biogenesis ◽  
Plant Mirnas ◽  
Signal To Noise ◽  
Advantages And Disadvantages ◽  
Plant Mirna ◽  
History Of ◽  
Mirna Biogenesis Pathway

Abstract Last two decades, the studies on microRNAs (miRNAs) and the numbers of annotated miRNAs in plants and animals have surged. Herein, we reviewed the current progress and challenges of miRNA annotation in plants. Via the comparison of plant and animal miRNAs, we pinpointed out the difficulties on plant miRNA annotation and proposed potential solutions. In terms of recalling the history of methods and criteria in plant miRNA annotation, we detailed how the major progresses made and evolved. By collecting and categorizing bioinformatics tools for plant miRNA annotation, we surveyed their advantages and disadvantages, especially for ones with the principle of mimicking the miRNA biogenesis pathway by parsing deeply sequenced small RNA (sRNA) libraries. In addition, we summarized all available databases hosting plant miRNAs, and posted the potential optimization solutions such as how to increase the signal-to-noise ratio (SNR) in these databases. Finally, we discussed the challenges and perspectives of plant miRNA annotations, and indicated the possibilities offered by an all-in-one tool and platform according to the integration of artificial intelligence.

scholarly journals Cross-Kingdom Regulation by Plant microRNAs Provides Novel Insight into Gene Regulation

2020 ◽  
Author(s):  
Abdul Fatah A Samad ◽  
Mohd Farizal Kamaroddin ◽  
Muhammad Sajad
Keyword(s):  
Gene Expression ◽  
Target Genes ◽  
Current Knowledge ◽  
Circulatory System ◽  
Dietary Therapy ◽  
Transcriptional Level ◽  
Plant Mirnas ◽  
Health Issues ◽  
Plant Mirna ◽  
Potential Applications

ABSTRACT microRNAs (miRNAs) are well known as major players in mammalian and plant genetic systems that act by regulating gene expression at the post-transcriptional level. These tiny molecules can regulate target genes (mRNAs) through either cleavage or translational inhibition. Recently, the discovery of plant-derived miRNAs showing cross-kingdom abilities to regulate mammalian gene expression has prompted exciting discussions among researchers. After being acquired orally through the diet, plant miRNAs can survive in the digestive tract, enter the circulatory system, and regulate endogenous mRNAs. Here, we review current knowledge regarding the cross-kingdom mechanisms of plant miRNAs, related controversies, and potential applications of these miRNAs in dietary therapy, which will provide new insights for plant miRNA investigations related to health issues in humans.

scholarly journals Plant miRNAs Reduce Cancer Cell Proliferation by Targeting MALAT1 and NEAT1: A Beneficial Cross-Kingdom Interaction

2020 ◽  
Vol 11 ◽  
Author(s):  
Flaviana Marzano ◽  
Mariano Francesco Caratozzolo ◽  
Arianna Consiglio ◽  
Flavio Licciulli ◽  
Sabino Liuni ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Plant Mirnas

scholarly journals Retraction Note: Circulating plant miRNAs can regulate human gene expression in vitro

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chiara Pastrello ◽  
Mike Tsay ◽  
Rosanne McQuaid ◽  
Mark Abovsky ◽  
Elisa Pasini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Gene ◽  
Plant Mirnas ◽  
Human Gene Expression

scholarly journals Adenylation of plant miRNAs

2009 ◽  
Vol 37 (6) ◽  
pp. 1878-1885 ◽  
Author(s):  
S. Lu ◽  
Y.-H. Sun ◽  
V. L. Chiang
Keyword(s):  
Plant Mirnas

scholarly journals Plant Microrna Potential in Targeting COVID-19 Genome Offering Efficient Antiviral Mirna-based Therapies

2021 ◽  
Author(s):  
Behzad Hajieghrari ◽  
Sara Rahmanian-Koshkaki
Keyword(s):  
Mirna Target ◽  
Protein Translation ◽  
Plant Mirnas ◽  
Novel Therapy ◽  
Great Chance ◽  
Virus Rna ◽  
Cell Gene Expression ◽  
Target Binding

Abstract In 2019, the seventh member of the Coronaviridae named severe acute respiratory coronavirus II (or COVID-19) emerged in Wuhan, China. It could rapidly turn into a global pandemic. Therefore, searching for a natural/ novel therapy is urgently essential to prevent disease distribution. Based on the principle of cross-kingdom interaction, plants are a candidate as a potential source of exogenous miRNAs that can efficiently affect the host cell gene expression by promote target mRNA degradation or repress protein translation, and, or virus RNA translation/replication. The possibility of taking up the diet-derived plant-originated/artificially miRNA(s) in addition to their biological role in the host provides a pivotal clue for the study of synthesized/artificially expressed active therapeutic plant-originated miRNA(s) to promote antiviral activity. In this study, plant miRNAs, which can potentially interact with the COVID-19 genome within the 3’-UTR region and prompt antiviral function, were searched using bioinformatics approaches. RNAHybrid, RNA22, and STarMir miRNA/target detection tools were served for the possible plant miRNA/target recognition on the 3’-UTR flanking region of the COVID-19 genome by different algorithms. The RNAHybrid algorithm resulted in 63 plant miRNAs having hybridization energy with less or equal to -25 kcal/mol. They interact with diverse classes of miRNA/target binding patterns. However, each RNA22 and STarMir tools identified eight probable miRNA/target interaction candidates, in which pvu-miR159a.2 and sbi-miR5387b detected by both the RNA22 and STarMir tools at the same position. For us, they are suitable plant-derived miRNA candidates, which have the great chance of targeting the COVID-19 genome in the 3’-UTR region in vitro to induce the virus degradation and translational repression and for antiviral miRNA-based therapies without any side effects in vivo.

scholarly journals A Timely Review of Cross-Kingdom Regulation of Plant-Derived MicroRNAs

2021 ◽  
Vol 12 ◽  
Author(s):  
Dan Li ◽  
Jianhui Yang ◽  
Yong Yang ◽  
Jianxin Liu ◽  
Hui Li ◽  
...  
Keyword(s):  
Immune Modulation ◽  
Current Knowledge ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Messenger Rnas ◽  
Plant Mirnas ◽  
Complementary Oligonucleotide ◽  
Density Lipoprotein Receptor ◽  
The Cross ◽  
The Stability

MicroRNAs (miRNAs) belong to a class of non-coding RNAs that suppress gene expression by complementary oligonucleotide binding to the sites in target messenger RNAs. Numerous studies have demonstrated that miRNAs play crucial role in virtually all cellular processes of both plants and animals, such as cell growth, cell division, differentiation, proliferation and apoptosis. The study of rice MIR168a has demonstrated for the first time that exogenous plant MIR168a influences cholesterol transport in mice by inhibiting low-density lipoprotein receptor adapter protein 1 expression. Inspired by this finding, the cross-kingdom regulation of plant-derived miRNAs has drawn a lot of attention because of its capability to provide novel therapeutic agents in the treatment of miRNA deregulation-related diseases. Notably, unlike mRNA, some plant miRNAs are robust because of their 3′ end modification, high G, C content, and the protection by microvesicles, miRNAs protein cofactors or plant ingredients. The stability of these small molecules guarantees the reliability of plant miRNAs in clinical application. Although the function of endogenous miRNAs has been widely investigated, the cross-kingdom regulation of plant-derived miRNAs is still in its infancy. Herein, this review summarizes the current knowledge regarding the anti-virus, anti-tumor, anti-inflammatory, anti-apoptosis, immune modulation, and intestinal function regulation effects of plant-derived miRNAs in mammals. It is expected that exploring the versatile role of plant-derived miRNAs may lay the foundation for further study and application of these newly recognized, non-toxic, and inexpensive plant active ingredients.

Research Progress of Exogenous Plant MiRNAs in Cross-Kingdom Regulation

2019 ◽  
Vol 14 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Hao Zhang ◽  
Mengping Zhan ◽  
Haowu Chang ◽  
Shizeng Song ◽  
Chunhe Zhang ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Sequencing ◽  
Isotope Labeling ◽  
Research Progress ◽  
Plant Mirnas ◽  
Sequencing Data ◽  
High Throughput Sequencing Data ◽  
Plant Mirna ◽  
Regulatory Effects ◽  
Regulation Model

Background:Studies have shown that exogenous miRNAs have cross-kingdom regulatory effects on bacteria and viruses, but whether exogenous plant miRNAs are stable in human body or participate in cross-kingdom regulation is still controversial.Objective:This study aims to propose a new method for the presence and cross-kingdom regulation pathway of exogenous Plant miRNA, which combines biological calculations and biological experiments.Method:Based on the high-throughput sequencing data of human health tissue, the tissue specificity model of exogenous plant miRNA can be constructed and the absorption characteristics will be excavated and analyzed. Then screening the exogenous Plant miRNA based on the crosskingdom regulation model of plant-human miRNA, and isotope labeling can be used to verify the presence and regulation pathway of exogenous plant miRNA.Results:Only based on a comprehensive analysis to human high-throughput miRNA data, establishing cross-kingdom regulation model and designing effective biological experiments, can we reveal the existence, access pathways and regulation of exogenous plant miRNAs.Conclusion:Here, we reviewed the most recent advances in the presence and pathway of exogenous plant miRNAs into human and their cross-kingdom regulation.

Sign in / Sign up

Export Citation Format

Share Document